Protein Alignment Keap1 and Klhl6

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: XP_063126397.1
• Gene: Klhl6 / 287974
• RGDID: 1307521
• Length: 647
• Species: Rattus norvegicus
• Alignment Length: 585
• Identity: 158/585 - (27%)
• Similarity: 260/585 - (44%)
• Gaps: 68/585 - (11%)

  Fly    83 MRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFK----------------------------AMF 119
            :|....||||:|.|..:.|..|:|||:|||.||:                            |||
  Rat    63 LREENALTDVILCVDIQEFSCHRVVLAAASNYFRSASRALSSTYSVSSVTGHHRDQNLFMNVAMF 127

  Fly   120 TGGLKESEMSRVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLE 184
            ...|||....|:.::||....|..:|.:.||.:..:|:..|.::|.||.:||...::|||.:||.
  Rat   128 CNDLKEKYEKRIIIKGVDAETMHTLLNYTYTSKALITKQNVQRVLEAANLFQFLQLVDACASFLT 192

  Fly   185 RQLDPTNAIGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQE 249
            ..|:|.|.|||...|:.|....|:.:...:|.:||.|:...||||:|....|..::|.|:|.|.|
  Rat   193 EALNPENCIGILRLADTHSLDSLKTQVQSYIIQNFVQILNSEEFLELPVDTLYHILRSDDLCVTE 257

  Fly   250 EREVYNAVLKWVKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFK 314
            |.:|:..|:.||::.:..|.|.:..:|..||...|.|.:..|.::...::|:.|.    :..:.:
  Rat   258 ESQVFETVMSWVRHKQSERLCLLPCVLENVRLPLLDPWYFVEMVEADPLIRQCPE----VFPLLQ 318

  Fly   315 DLTLHKCPG---VKERT-PN----TTRMIFVAGGFFRHSLDILEAYNVDDMTWTTLANLRIPRS- 370
            :..::...|   :.||| |.    .:.:..:.||..:....:.|...:|.:..:.|...::|.:
  Rat   319 EARMYHLSGNEIISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPLTE 383

  Fly   371 -----------GLGAAFLKGKFYAVGGRNNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVG 424
                       ......||.:.|..||:.    :.:|   |.:|::....|.....:::.|.|..
  Rat   384 HELESENKKWVEFACVTLKNEVYISGGKE----TQHD---VWKYNSSINKWIQIEYLNIGRWRHK 441

  Fly   425 VAVMDELMYAVGGSAGMEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNE 489
            :.|:...:|.:||..|::..|.||.|||..:.|:...|:.............:.||.||| ..|.
  Rat   442 MVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGG-GPNG 505

  Fly   490 RLAS--VECYHPENNEWSFLPPLQTGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWD 552
            :||:  .:||.|..|:|.....:..........:...:||||||     .:..:..|....|:|.
  Rat   506 KLATDKTQCYDPSTNKWVLKSAMPVEAKCINAVSFQDHIYVVGG-----AMRALYAYSPLEDSWC 565

  Fly   553 MVAPIQIARSALSLTPLDEKLYAIGGFD-GNNFLSIVEVYDPRTNTWTTGTPLKSGRSGHASAVI 616
            :|..:...|::..:.|.:.|||..||.| .|..::.|..:||.....|....|..|.|.|.|..|
  Rat   566 LVTQLSHERASCGIAPCNNKLYITGGRDEKNEVIATVLCWDPEAQKLTEECVLPRGVSHHGSVTI 630

  Fly   617  616
              Rat   631  630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	147/557 (26%)
		KELCH repeat	369..416	CDD:276965	9/58 (16%)
		KELCH repeat	420..463	CDD:276965	14/42 (33%)
		KELCH repeat	467..510	CDD:276965	13/44 (30%)
		KELCH repeat	514..558	CDD:276965	10/43 (23%)
		KELCH repeat	561..606	CDD:276965	14/45 (31%)
Klhl6	XP_063126397.1	None