DRSC/TRiP Functional Genomics Resources

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Protein Alignment Keap1 and KLHL35

DIOPT Version :10

Sequence 1:NP_732202.2 Gene:Keap1 / 42062 FlyBaseID:FBgn0038475 Length:776 Species:Drosophila melanogaster
Sequence 2:NP_001034637.2 Gene:KLHL35 / 283212 HGNCID:26597 Length:583 Species:Homo sapiens


Alignment Length:623 Identity:159/623 - (25%)
Similarity:249/623 - (39%) Gaps:122/623 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 PEEAEMSNTSESCSISCGGRFGSAHSTLDDHDATDDDMTFCMSNYAKEALKMMYMMRSHGMLTDV 92
            |||:|     ..|...|.|.                    |   :|:..|:.:...|..|.||||
Human     7 PEESE-----PGCEAPCAGP--------------------C---HAQRVLQALNAYRRSGTLTDV 43

  Fly    93 VLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQLQGVCP-----------TAMSRILY 146
            ||......||.|:..|||.|.||:::|..|..|...:.|.:..|.|           .|::.:|.
Human    44 VLRAGGRDFPCHRAALSAGSAYFRSLFAAGRPERGPAVVPVVPVAPEAPGTSPAGAAAALAVVLD 108

  Fly   147 FMYTGQIRV-TEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHFAEQHGCVELQKK 210
            ::|...:|: .|.....:|..|....|..:.:||..|||.:|...|::.:...|.......|.::
Human   109 YVYGAGVRLRAEDEAAAVLALAERLGVAGLREACVRFLEGRLRAANSLALRRVAAAFSLAPLAER 173

  Fly   211 ANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWVKYDEDNRHCKMEHI 275
            ....:.:.|.:|.:..:||:|:..:::||:....|.|..|..|:.|.::||::|...|..::..:
Human   174 CGRVLRQAFAEVARHADFLELAPDEVVALLADPALGVAREEAVFEAAMRWVRHDAPARRGQLRRL 238

  Fly   276 LGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFKDLTLHKCPGVKERTP----NTTRMIF 336
            |..||...|.|.:..|:::..::|:....||..|.:......|.:..|.....|    :...:|.
Human   239 LEHVRLPLLAPAYFLEKVEADELLQACGECRPLLLEARACFILGREAGALRTRPRRFMDLAEVIV 303

  Fly   337 VAGGFFRH---SLDILEAYNVDDMTWTTLANL-RIPRSGLGAAFLKGKFYAVGGRNNNIGSSYDS 397
            |.||..|.   .|...:||:.:...||.|.:| ...||...|..|:...|..||..|    |:| 
Human   304 VIGGCDRKGLLKLPFADAYHPESQRWTPLPSLPGYTRSEFAACALRNDVYVSGGHIN----SHD- 363

  Fly   398 DWVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGGSAGMEYHNTVEYYDPDLDRWTLVQP 462
                       .|                                      .:...|..|..|..
Human   364 -----------VW--------------------------------------MFSSHLHTWIKVAS 379

  Fly   463 MHAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYHPENNEWSFLPPLQTGRSGAGVAAINQYIY 527
            :|..|....:.||...|:|:|||||..||.|||.|.|.:|.|:...||....|.|.||:....::
Human   380 LHKGRWRHKMAVVQGQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGKLF 444

  Fly   528 VVGGF-DGTRQLATVERYDTENDTWDMVAPIQIARSALSLTPLDEKLYAIGGFDGNNFLSIVEVY 591
            |:||. .|......|:.:|.:.|.|.:.:|...::..|....|::.:|.:||     .:|.:..|
Human   445 VIGGARQGGVNTDKVQCFDPKEDRWSLRSPAPFSQRCLEAVSLEDTIYVMGG-----LMSKIFTY 504

  Fly   592 DPRTNTWTTGTPLKSGRSGHASAVIYQP--ACSTTFMD 627
            ||.|:.|           |.| ||:..|  :|..|..|
Human   505 DPGTDVW-----------GEA-AVLPSPVESCGVTVCD 530

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Keap1NP_732202.2 PHA03098 92..599 CDD:222983 135/527 (26%)
KELCH repeat 369..416 CDD:276965 11/46 (24%)
KELCH repeat 420..463 CDD:276965 3/42 (7%)
KELCH repeat 467..510 CDD:276965 19/42 (45%)
KELCH repeat 514..558 CDD:276965 13/44 (30%)
KELCH repeat 561..606 CDD:276965 11/44 (25%)
KLHL35NP_001034637.2 BTB_POZ_KLHL35 18..157 CDD:349574 43/161 (27%)
BACK 156..255 CDD:197943 23/98 (23%)
Kelch 1 301..350 16/48 (33%)
NanM 302..553 CDD:442289 80/300 (27%)
KELCH repeat 340..380 CDD:276965 14/93 (15%)
Kelch 2 352..394 14/95 (15%)
KELCH repeat 384..428 CDD:276965 20/43 (47%)
Kelch 3 395..441 22/45 (49%)
KELCH repeat 431..476 CDD:276965 13/44 (30%)
Kelch 4 443..489 11/45 (24%)
KELCH repeat 479..519 CDD:276965 15/56 (27%)
Kelch 5 490..531 17/58 (29%)
KELCH repeat 521..566 CDD:276965 3/10 (30%)
Kelch 532..577 CDD:128874
Kelch 6 533..579
Blue background indicates that the domain is not in the aligned region.

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