DRSC/TRiP Functional Genomics Resources

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Protein Alignment Keap1 and Klhl23

DIOPT Version :10

Sequence 1:NP_732202.2 Gene:Keap1 / 42062 FlyBaseID:FBgn0038475 Length:776 Species:Drosophila melanogaster
Sequence 2:NP_808452.2 Gene:Klhl23 / 277396 MGIID:2683536 Length:558 Species:Mus musculus


Alignment Length:563 Identity:163/563 - (28%)
Similarity:262/563 - (46%) Gaps:50/563 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    75 EALKMMYMMRSHGMLTDVVLEVKKE-LFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQLQGVCP 138
            :|.:..||   .|:.||:.|:.... :|..|:.||:|.|.|||||||..:||...|:::|.|:..
Mouse    24 DAFRTFYM---DGLFTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKSKIKLSGIHH 85

  Fly   139 TAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHFAEQHG 203
            ..:..::.:.||.||.:|:..|..||.||.:.|..:|..||..||.|.||..|.||:..|||.|.
Mouse    86 DILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACEQFLVRHLDIDNCIGMHSFAEFHV 150

  Fly   204 CVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWVKYDEDNR 268
            |.||:|::...:...|.:|.|:||||::|..:.:.::.|..|:|.:|..:...|:||..:|.:||
Mouse   151 CSELEKESRRILCSRFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAILEPVIKWTAHDVENR 215

  Fly   269 HCKMEHILGAVRCQFLTPNFLKEQM---KNC----DVLRKVPACREYLAKIFKDLTLHKCPGVKE 326
            ...:.::|..:... :.|.:||..:   ::|    :.:|.:         |:..|.    |..||
Mouse   216 IECIYNLLSYINID-IDPVYLKTALGLQRSCLLTENKIRSL---------IYNALN----PMHKE 266

  Fly   327 RTPNTTRMIFVAGGFFRHSLDILEAYNVDDMTWTTLANLRIP---RSGLGAAFLKGKFYAVGG-R 387
            .:..:|..:::.||::.|.|.  |.:..|.:|...:....||   |...|...|....|..|| |
Mouse   267 ISQRSTATMYIIGGYYWHPLS--EVHIWDPLTNVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYR 329

  Fly   388 NNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGGSAGMEYHNTVEYYDP 452
            .:|| .:.|:.|:  |::..:.|....||...|:......:...:||:||..........|:|||
Mouse   330 TDNI-DALDTVWI--YNSEGDEWTEGLPMLNARYYHCAVTLGGCVYALGGYRKGAPAEEAEFYDP 391

  Fly   453 DLDRWTLVQPMHAKRLGVG---VVVVNRLLYAIG---GFDGNERLASVECYHPENNEWSFLPPLQ 511
            ..::|.   |:.....|||   ..|::.::|.||   |:.|:.....|:.|:.:.||||.:....
Mouse   392 LKEKWL---PIANMIKGVGNATACVLHEVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITASP 453

  Fly   512 TGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWDMVAPIQIARSALSLTPLDEKLYAI 576
            ....|.........:|:|||     |....|.||.|.:.|...||:...|.......::..:|..
Mouse   454 HPEYGLCSVPFENKLYLVGG-----QTTITECYDPEQNEWRETAPMMERRMECGAVIMNGCIYVT 513

  Fly   577 GG--FDGNNFLSIVEVYDPRTNTWTTGTPLKSGRSGHASAVIY 617
            ||  :....:|..:|.|||..|.|.....|.|....|....:|
Mouse   514 GGYSYSKGTYLQSIEKYDPDLNKWEIVGNLPSAMRSHGCVCVY 556

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Keap1NP_732202.2 PHA03098 92..599 CDD:222983 152/526 (29%)
KELCH repeat 369..416 CDD:276965 13/47 (28%)
KELCH repeat 420..463 CDD:276965 10/42 (24%)
KELCH repeat 467..510 CDD:276965 15/48 (31%)
KELCH repeat 514..558 CDD:276965 13/43 (30%)
KELCH repeat 561..606 CDD:276965 12/46 (26%)
Klhl23NP_808452.2 BTB_POZ_KLHL23 15..141 CDD:349561 45/119 (38%)
PHA03098 45..545 CDD:222983 153/526 (29%)
BACK_KLHL23 134..235 CDD:350537 33/101 (33%)
Kelch 1 274..320 12/47 (26%)
KELCH repeat 310..355 CDD:276965 13/47 (28%)
Kelch 2 321..369 13/50 (26%)
KELCH repeat 359..402 CDD:276965 11/45 (24%)
Kelch 3 370..416 14/48 (29%)
KELCH repeat 406..495 CDD:276965 27/93 (29%)
Kelch 4 418..466 12/47 (26%)
Kelch 5 467..508 13/45 (29%)
KELCH repeat 498..545 CDD:276965 12/46 (26%)
Kelch 6 510..557 14/47 (30%)

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