DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Keap1 and KLHL20

DIOPT Version :9

Sequence 1:	NP_732202.2	Gene:	Keap1 / 42062	FlyBaseID:	FBgn0038475	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	XP_016856541.1	Gene:	KLHL20 / 27252	HGNCID:	25056	Length:	684	Species:	Homo sapiens

Alignment Length:	631	Identity:	233/631 - (36%)
Similarity:	335/631 - (53%)	Gaps:	44/631 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PMQYETHISDMPNHKGYPCRPEEAEMSNTSESCSISCGGRFGSAHSTLDDHDATDDD------MT 66
            ||:..|:|           ||.|..|..||.     |         ||.|.:...:.      |.
Human    80 PMRRCTNI-----------RPGETGMDVTSR-----C---------TLGDPNKLPEGVPQPARMP 119

  Fly    67 FCMSNYAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRV 131
            :....:.::.|:::.::|.|..|.||||.|..:...||:|:|||.||||:|||||.|.||..:.|
Human   120 YISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEV 184

  Fly   132 QLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIA 196
            .::.:...||..::.|.||.||.|.|..|..|||||.:.|:..:.:|||.||:|||||:|.:||.
Human   185 VIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIR 249

  Fly   197 HFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWV 261
            .||:.|.|.||.:.|:.|.:.||.:|.:.|||:.|.|.|||.:|..|||||:.|.:|:|||:.||
Human   250 AFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWV 314

  Fly   262 KYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYL--AKIF----KDLTLHK 320
            ||....|..::..:|..||...|:|.||...:.:..:::....||:.:  ||.:    ::..|.:
Human   315 KYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDEAKNYLLLPQERPLMQ 379

  Fly   321 CPGVKERTP-NTTRMIFVAGGFFR-HSLDILEAYNVDDMTWTTLANLRIPRSGLGAAFLKGKFYA 383
            .|..:.|.| ....::|..||:.. .::..:|.|:.....|..:|::...|.|:|.:.|....||
Human   380 GPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYA 444

  Fly   384 VGGRNNNIGSSYDSDWVDRYSAVTETW-RPCAPMSVPRHRVGVAVMDELMYAVGGSAGMEYHNTV 447
            |||.:   ||||.:. |:||...|..| ...||.|..|..|||||:...:|||||..|:...|.|
Human   445 VGGHD---GSSYLNS-VERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIV 505

  Fly   448 EYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYHPENNEWSFLPPLQT 512
            |.|||..::||.|..|..:||||.|.|:...|||:||.||...|.:||.|:|:.|.|..:.|:.|
Human   506 ERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGT 570

  Fly   513 GRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWDMVAPIQIARSALSLTPLDEKLYAIG 577
            .|...|.|.....||.|||.|.|.:|::.|||:...:.|..|..:...||.:.|..::.:|.|:|
Human   571 RRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVG 635

  Fly   578 GFDGNNFLSIVEVYDPRTNTWTTGTPLKSGRSGHASAVIYQPACST 623
            ||||..:|..:||:||..|||.....:...|.|....||....|.:
Human   636 GFDGTTYLKTIEVFDPDANTWRLYGGMNYRRLGGGVGVIKMTHCES 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	BTB	80..183	CDD:279045	46/102 (45%)
		PHA03098	92..599	CDD:222983	207/515 (40%)
		BACK	192..294	CDD:285009	44/101 (44%)
		Kelch	335..379	CDD:128874	11/44 (25%)
		KELCH repeat	369..416	CDD:276965	19/47 (40%)
		Kelch	382..430	CDD:128874	23/48 (48%)
		KELCH repeat	420..463	CDD:276965	21/42 (50%)
		Kelch	433..476	CDD:128874	22/42 (52%)
		KELCH repeat	467..510	CDD:276965	20/42 (48%)
		Kelch	478..523	CDD:128874	19/44 (43%)
		KELCH repeat	514..558	CDD:276965	16/43 (37%)
		Kelch_1	514..556	CDD:279660	16/41 (39%)
		KELCH repeat	561..606	CDD:276965	18/44 (41%)
		Kelch	572..616	CDD:128874	17/43 (40%)
KLHL20	XP_016856541.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820