DRSC/TRiP Functional Genomics Resources

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Protein Alignment Keap1 and KBTBD2

DIOPT Version :10

Sequence 1:NP_732202.2 Gene:Keap1 / 42062 FlyBaseID:FBgn0038475 Length:776 Species:Drosophila melanogaster
Sequence 2:NP_056298.2 Gene:KBTBD2 / 25948 HGNCID:21751 Length:623 Species:Homo sapiens


Alignment Length:577 Identity:160/577 - (27%)
Similarity:238/577 - (41%) Gaps:127/577 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    53 STLDDHDATDDDMTFCMSNYAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKA 117
            ||.|:....        :.||...|:.:.:.....:.||:||.|:...||.||:||:..|.||:|
Human     2 STQDERQIN--------TEYAVSLLEQLKLFYEQQLFTDIVLIVEGTEFPCHKMVLATCSSYFRA 58

  Fly   118 MFTGGLKESEMSRVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAF 182
            ||..||.||:.:.|.|:.|....:..|:.:.|||.:.:.:.||.||...|...||.:|:..|..:
Human    59 MFMSGLSESKQTHVHLRNVDAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRCREY 123

  Fly   183 LERQLDPTNAIGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNV 247
            |.::::..|.:.:..||:...|.||::.|...:|..||.|..::.|:|||...||.::..|.|||
Human   124 LIKKINAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDILSSDNLNV 188

  Fly   248 QEEREVYNAVLKWVKYDEDNRHCKMEHILGAVRC------------QFLTPN------------- 287
            ::|..|..|.:.|::|:.::|...:..:|..:|.            |.|.||             
Human   189 EKEETVREAAMLWLEYNTESRSQYLSSVLSQIRIDALSEVTQRAWFQGLPPNDKSVVVQGLYKSM 253

  Fly   288 ---------FLKEQM---------KNCDVLRKVPACREYLA-KIFK----DLTLHKCPGVKERTP 329
                     ..||:|         ..|.:...|  |....| |::|    ...|||...|.  ||
Human   254 PKFFKPRLGMTKEEMMIFIEASSENPCSLYSSV--CYSPQAEKVYKLCSPPADLHKVGTVV--TP 314

  Fly   330 NTTRMIFVAGGFFRHSLDILEAYNVDDMTWTTLANLRI---PRSGLGAAFLKGKFYAVGGRNNNI 391
            :..  |::|||                  ...|.|.:.   ..|.|..||            ..:
Human   315 DND--IYIAGG------------------QVPLKNTKTNHSKTSKLQTAF------------RTV 347

  Fly   392 GSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGG-SAGMEYH-NTVEYYDPDL 454
            ...|   |.|   |...||.|..||...|.:..:...:..:||:|| |.|.|.: .|||.||.:.
Human   348 NCFY---WFD---AQQNTWFPKTPMLFVRIKPSLVCCEGYIYAIGGDSVGGELNRRTVERYDTEK 406

  Fly   455 DRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYHPENNEWSFLPPLQTGRSGAGV 519
            |.||:|.|:.........|||:..:|.:       .|..:.||.|.::.|..:...||.||.|..
Human   407 DEWTMVSPLPCAWQWSAAVVVHDCIYVM-------TLNLMYCYFPRSDSWVEMAMRQTSRSFASA 464

  Fly   520 AAINQYIYVVGGF---------------DGTRQLATVERYDTENDTWDMVAPIQIAR 561
            ||....|:.:||.               ||:.  .|||.||...:.|.|.|.|...|
Human   465 AAFGDKIFYIGGLHIATNSGIRLPSGTVDGSS--VTVEIYDVNKNEWKMAANIPAKR 519

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Keap1NP_732202.2 PHA03098 92..599 CDD:222983 152/538 (28%)
KELCH repeat 369..416 CDD:276965 11/46 (24%)
KELCH repeat 420..463 CDD:276965 17/44 (39%)
KELCH repeat 467..510 CDD:276965 9/42 (21%)
KELCH repeat 514..558 CDD:276965 18/58 (31%)
KELCH repeat 561..606 CDD:276965 1/1 (100%)
KBTBD2NP_056298.2 BTB_POZ_KBTBD2_BKLHD1 5..137 CDD:349579 43/139 (31%)
PHA03098 23..516 CDD:222983 152/543 (28%)
BACK_KBTBD2 128..223 CDD:350554 29/94 (31%)
KELCH repeat 310..366 CDD:276965 20/95 (21%)
Kelch 1. /evidence=ECO:0000255 317..380 20/100 (20%)
KELCH repeat 370..416 CDD:276965 18/45 (40%)
Kelch 2. /evidence=ECO:0000255 381..429 20/47 (43%)
KELCH repeat 419..453 CDD:276965 9/40 (23%)
Kelch 3. /evidence=ECO:0000255 431..469 13/44 (30%)
KELCH repeat 459..516 CDD:276965 18/58 (31%)
Kelch 4. /evidence=ECO:0000255 470..529 15/52 (29%)
KELCH repeat 519..568 CDD:276965 1/1 (100%)
Kelch 5. /evidence=ECO:0000255 535..581
Blue background indicates that the domain is not in the aligned region.

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