DRSC/TRiP Functional Genomics Resources

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Protein Alignment Keap1 and Klhl9

DIOPT Version :10

Sequence 1:NP_732202.2 Gene:Keap1 / 42062 FlyBaseID:FBgn0038475 Length:776 Species:Drosophila melanogaster
Sequence 2:NP_766459.2 Gene:Klhl9 / 242521 MGIID:2180122 Length:617 Species:Mus musculus


Alignment Length:606 Identity:160/606 - (26%)
Similarity:273/606 - (45%) Gaps:46/606 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    67 FCMSNYAKEALKMMYMMRSHGMLTDVVLEV--KKELFPAHKVVLSAASPYFKAMFTGGLKESEMS 129
            |..:.::...|:....:|..|:|.||.|..  .:|:||.|:.::::||.|||||||||:||.::.
Mouse    27 FTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGEEIFPVHRAMMASASDYFKAMFTGGMKEKDLM 91

  Fly   130 RVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIG 194
            .::|.||....:.:|:.|:||.::.:....:...|.||:..|:..|:|.|..||...:...|.:.
Mouse    92 CIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVSLDNCVE 156

  Fly   195 IAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLK 259
            :...|..:..:|:.|..|.||.:||..:....|||:|...:|..::..:.|....|.|::.|..:
Mouse   157 VGRIANTYNLIEVDKYVNNFILKNFPALLNTGEFLKLPFERLAFVLSSNSLKHCSELELFKAACR 221

  Fly   260 WVKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYL--AKIFKDLTLHKCP 322
            |::. ||.|......::..:|...:||..|...::..|.:|....|...|  |..::.:...:..
Mouse   222 WLRL-EDPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPV 285

  Fly   323 GVKERT---PNTTRMIFVAGGFFRHSLDI---LEAYNVDDMTWTTLANLRIPRSGLGAAFLKGKF 381
            ...:||   .::|.:: ..||..|..|.:   |..|:.....|.:||.:..||...|.|.:....
Mouse   286 MQSDRTAIRSDSTHLV-TLGGVLRQQLVVSKELRMYDERAQEWKSLAPMDAPRYQHGIAVIGNFL 349

  Fly   382 YAVGGRNNNIGSSYDS------DWVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGGSAG 440
            |.|||::|     ||:      |.|.|:......|...|.::..|....::.:...:|||||.:.
Mouse   350 YVVGGQSN-----YDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSA 409

  Fly   441 MEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYHPENNEWS 505
            .....|||.|:|.::.|:.|..|.....|....|...|:|..||...:.....:.|:.|:.::|:
Mouse   410 AGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWT 474

  Fly   506 FLPPLQTGRSGAGVAAINQYIYVVGG--FDGTR---QLATVERYDTENDTWDMVAPIQIARSALS 565
            ...|:.|.|....:..:...:||:||  |.||.   .:.:.|.|....|.|..:|.:...:|.:.
Mouse   475 QKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVG 539

  Fly   566 LTPLDEKLYAIGGFDGNN--FLSIVEVYDPRTNTWTTGTPLKSGRSGHASAVIYQPACSTTFMDY 628
            :...:.|:|.:||:..||  .:.||:.|||..:.|.....|.....|..       ||:.|..  
Mouse   540 VAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIR-------ACTLTVF-- 595

  Fly   629 EDSDAPHPDGSNNGERNAHTP 649
                   |...|.|..:..:|
Mouse   596 -------PPEENPGSPSRESP 609

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Keap1NP_732202.2 PHA03098 92..599 CDD:222983 144/529 (27%)
KELCH repeat 369..416 CDD:276965 15/52 (29%)
KELCH repeat 420..463 CDD:276965 13/42 (31%)
KELCH repeat 467..510 CDD:276965 9/42 (21%)
KELCH repeat 514..558 CDD:276965 13/48 (27%)
KELCH repeat 561..606 CDD:276965 14/46 (30%)
Klhl9NP_766459.2 BTB_POZ_KLHL9_13 27..154 CDD:349548 41/126 (33%)
PHA03098 50..593 CDD:222983 150/556 (27%)
Kelch 1 299..347 13/48 (27%)
KELCH repeat 337..385 CDD:276965 15/52 (29%)
Kelch 2 348..399 13/55 (24%)
KELCH repeat 389..433 CDD:276965 13/43 (30%)
Kelch 3 400..446 15/45 (33%)
KELCH repeat 436..481 CDD:276965 10/44 (23%)
Kelch 4 448..493 9/44 (20%)
KELCH repeat 483..532 CDD:276965 13/48 (27%)
Kelch 5 495..545 13/49 (27%)
KELCH repeat 535..582 CDD:276965 14/46 (30%)
Kelch 6 546..594 16/54 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 595..617 4/24 (17%)

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