DRSC/TRiP Functional Genomics Resources

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Protein Alignment Keap1 and Klhl4

DIOPT Version :10

Sequence 1:NP_732202.2 Gene:Keap1 / 42062 FlyBaseID:FBgn0038475 Length:776 Species:Drosophila melanogaster
Sequence 2:NP_766369.2 Gene:Klhl4 / 237010 MGIID:2442829 Length:717 Species:Mus musculus


Alignment Length:624 Identity:215/624 - (34%)
Similarity:326/624 - (52%) Gaps:54/624 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 MQYETHISDMPNHKGYPCRPEEAEMSNTSESCSISCGGRFGSAHSTLDDH--DATDDDMTFC-MS 70
            |..:.:|.||   :..||..|..:|:.:|                  :||  ..:..|.|.| |.
Mouse   129 MMGDDNIEDM---RAGPCVEEPEQMTTSS------------------NDHYRSRSHADYTLCKME 172

  Fly    71 NYAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQLQG 135
            :|.||.           .|.||:|.......|||::||||.|.||.||||..:.|:....|:::|
Mouse   173 SYLKER-----------KLCDVLLIAGPLKIPAHRLVLSAVSDYFAAMFTNDVLEARQEEVKIEG 226

  Fly   136 VCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHFAE 200
            |.|.|::.::.:.|||.:::.|.|:..||.||.:.|:..|||.||.||.:||.|:|.:||..|.:
Mouse   227 VDPNALNSLVQYAYTGVLQLREDTIENLLSAACLLQLTQVIDVCCNFLIKQLHPSNCLGIRSFGD 291

  Fly   201 QHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWVKYDE 265
            ..||:|||..|:.:...:|..|.:.:|||.|.|.::..|:..|::||.:|..:::|:::||.:|.
Mouse   292 AQGCMELQNVAHKYAMEHFIDVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDA 356

  Fly   266 DNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFK------DLTLHKCPGV 324
            ..|...:..:|..:|...|:|..|.: ::|.........|::.|.:..|      ..::.:.|..
Mouse   357 QARQRDLAKLLSYIRLPLLSPQLLAD-LENSSFFSGNLECQKLLMEAMKYHLLPERRSMLQSPRT 420

  Fly   325 KERTPNTTRMIFVAGGF-FRHSLDILEAYNVDDMTWTTLANLRIPRSGLGAAFLKGKFYAVGGRN 388
            |.| .:|...::..||. .......:|.|::...:|..:..:...|...|.|.:..|.|.||||:
Mouse   421 KPR-KSTVGALYAVGGMDAAKGTTTIEKYDLRTNSWIHIGTMSGRRLQFGVAVVDNKLYVVGGRD 484

  Fly   389 NNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGGSAGMEYHNTVEYYDPD 453
                .....:.|:.::.||:||....|||..||.:|||.::..||||||..|..|.||||.:|||
Mouse   485 ----GLKTLNTVECFNPVTKTWVVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPD 545

  Fly   454 LDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYHPENNEWSFLPPLQTGRSGAG 518
            ..:|..|..|...|..||||.:|..||||||.||:..|.|:|.:.|..|:||...|:...|.|.|
Mouse   546 GRQWNYVASMSTPRSTVGVVALNNRLYAIGGRDGSSCLKSMEFFDPHTNKWSLCAPMSKRRGGVG 610

  Fly   519 VAAINQYIYVVGGFDG------TRQLATVERYDTENDTWDMVAPIQIARSALSLTPLDEKLYAIG 577
            ||..|.|:|||||.|.      :|....|||||.:.|:|..|||:.:.|.|:::.||.:|||.:|
Mouse   611 VATHNGYLYVVGGHDAPAPNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVG 675

  Fly   578 GFDGNNFLSIVEVYDPRTNTWTTGTPLKSGRSGHASAVI 616
            |:||:.:|:.||.||.:.:.|....|:..||:|....|:
Mouse   676 GYDGHTYLNTVESYDAQKDEWKEEVPVNIGRAGACVVVV 714

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Keap1NP_732202.2 PHA03098 92..599 CDD:222983 189/519 (36%)
KELCH repeat 369..416 CDD:276965 14/46 (30%)
KELCH repeat 420..463 CDD:276965 22/42 (52%)
KELCH repeat 467..510 CDD:276965 21/42 (50%)
KELCH repeat 514..558 CDD:276965 24/49 (49%)
KELCH repeat 561..606 CDD:276965 18/44 (41%)
Klhl4NP_766369.2 PHA03098 175..697 CDD:222983 193/538 (36%)
KELCH repeat 465..508 CDD:276965 14/46 (30%)
KELCH repeat 512..556 CDD:276965 22/43 (51%)
KELCH repeat 559..602 CDD:276965 21/42 (50%)
KELCH repeat 606..657 CDD:276965 24/50 (48%)
KELCH repeat 659..698 CDD:276965 17/38 (45%)

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