DRSC/TRiP Functional Genomics Resources

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Protein Alignment Keap1 and Klhl26

DIOPT Version :10

Sequence 1:NP_732202.2 Gene:Keap1 / 42062 FlyBaseID:FBgn0038475 Length:776 Species:Drosophila melanogaster
Sequence 2:NP_848886.1 Gene:Klhl26 / 234378 MGIID:2443079 Length:606 Species:Mus musculus


Alignment Length:589 Identity:162/589 - (27%)
Similarity:264/589 - (44%) Gaps:76/589 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 GGRFGSAHSTLDDHDATDDD----MTFCMSNYAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHK 105
            ||..||:.|........|.:    .||..:.::...|:.:..:|:.|.|.||||.|..|.|.|||
Mouse     5 GGSSGSSQSPERPSSLADRNGALKCTFSAAGHSTGLLQGLAALRAQGQLLDVVLTVNSEAFHAHK 69

  Fly   106 VVLSAASPYFKAMFTGGLKESEMSRVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMF 170
            |||:|.|.||:||||||::|:..:.:|||||....:..|:.|.|:.::.:....|..:|.||...
Mouse    70 VVLAACSDYFRAMFTGGMREANQAVIQLQGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFL 134

  Fly   171 QVPNVIDACCAFLERQLDPTNAIGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQ 235
            |:..|::.|..||:..:.....:.|...|.......|::..:.|..|:|.|:..||:||:|...:
Mouse   135 QMLPVVELCEDFLKAAMSVETCLHIGQMATTFSLTSLRESVDAFTFRHFLQIAAEEDFLRLPLER 199

  Fly   236 LIALIRRDELNVQEEREVYNAVLKWVKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLR 300
            |:..::.:.|....|.:::.|.::|:::| ..|..:...:|..||...:.|..|.:.::..||:.
Mouse   200 LVFFLQSNRLQSCAEIDLFRAAVRWLQHD-PARRARASLVLRHVRFPLMQPAELVDSVQTLDVML 263

  Fly   301 KVPACREYLAKIFKDLTLHKCPGVKERTPNTTRMIFVA-----GGFFRHSLDILEAYNVDDMTWT 360
            ....||:||.:.|....| .|.....::|.|.....||     ||         ..|...|...:
Mouse   264 DDALCRQYLLEAFSYHVL-PCRQHDMQSPRTAVRSDVASLVAFGG---------TPYTDSDRAVS 318

  Fly   361 TLANLRIPRSGLGAAFLKGKFYAVGGRNNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGV 425
            :.. .::|..|                            ...:..:||....|:       ..||
Mouse   319 SKV-FQLPEPG----------------------------ARHFRELTEMELGCS-------HAGV 347

  Fly   426 AVMDELMYAVGGS-----AGMEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGF 485
            ||:|..:|..||.     :|....:....|||..:||..::.:...|:...:..:..||||.||.
Mouse   348 AVLDNFVYVAGGQHLQHRSGEGAVDACYRYDPQRNRWLRLRALRESRVQFQLTALGGLLYATGGR 412

  Fly   486 DGNERLASVECYHPENNEWSFLPPLQTGRSG-AGVAAINQYIYVVGGFD-GTRQLATVERYDTEN 548
            :....|||||.|.|..:.|.|..||:....| ||.||..: :|:.||:. .......::.||...
Mouse   413 NRAGSLASVERYCPRRDSWDFACPLKRRTWGHAGAAAAGR-LYISGGYGVSAEDKKALQCYDPAA 476

  Fly   549 DTWDMVAPIQIARSALSLTPLDEKLYAIGG--------FDGNNFLSIVEVYDPRTNTWTTGTPLK 605
            |.|:..||::..|...::.....::||:||        ||    :..||.|.|..:.||:.||::
Mouse   477 DRWEPRAPMREPRVLHAMLGAAGRIYALGGRMDHVDRCFD----VLAVEYYVPDADQWTSVTPMR 537

  Fly   606 SGRS 609
            :|:|
Mouse   538 AGQS 541

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Keap1NP_732202.2 PHA03098 92..599 CDD:222983 143/526 (27%)
KELCH repeat 369..416 CDD:276965 4/46 (9%)
KELCH repeat 420..463 CDD:276965 14/47 (30%)
KELCH repeat 467..510 CDD:276965 16/42 (38%)
KELCH repeat 514..558 CDD:276965 14/45 (31%)
KELCH repeat 561..606 CDD:276965 15/52 (29%)
Klhl26NP_848886.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20 5/14 (36%)
BTB_POZ_KLHL26 36..156 CDD:349564 45/119 (38%)
BACK 151..247 CDD:475122 22/96 (23%)
Kelch 1 301..352 13/95 (14%)
NanM 331..580 CDD:442289 66/223 (30%)
KELCH repeat 343..390 CDD:276965 14/53 (26%)
Kelch 2 353..404 10/50 (20%)
KELCH repeat 394..438 CDD:276965 17/43 (40%)
Kelch 3 406..451 21/44 (48%)
KELCH repeat 441..487 CDD:276965 14/46 (30%)
Kelch 4 452..499 10/47 (21%)
KELCH repeat 489..536 CDD:276965 14/50 (28%)
Kelch 5 501..550 16/45 (36%)
KELCH repeat 541..597 CDD:276965 1/1 (100%)
Kelch 6 552..599
Blue background indicates that the domain is not in the aligned region.

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