DRSC/TRiP Functional Genomics Resources

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Protein Alignment Keap1 and KLHL18

DIOPT Version :10

Sequence 1:NP_732202.2 Gene:Keap1 / 42062 FlyBaseID:FBgn0038475 Length:776 Species:Drosophila melanogaster
Sequence 2:XP_005265058.2 Gene:KLHL18 / 23276 HGNCID:29120 Length:584 Species:Homo sapiens


Alignment Length:609 Identity:196/609 - (32%)
Similarity:298/609 - (48%) Gaps:93/609 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    56 DDHDATDDDMTFCMSNYAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFT 120
            |..:..:|.:.|.:|........:|..:|..|.|.||.|::....|.||::||:|:.|||.||||
Human     4 DGAEELEDLVHFSVSELPSRGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFT 68

  Fly   121 GGLKESEMSRVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLER 185
            ..:.|.:...:.:||:.|:|:..::.|.|.|.:.:.:..|..||..|:..|:.::.||||.||..
Human    69 NDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRE 133

  Fly   186 QLDPTNAIGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEE 250
            :|.|.|.:|:..|||...|..|...||.||.::|.:|...||||.|....::.|:.||||||:.|
Human   134 RLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSE 198

  Fly   251 REVYNAVLKWVKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFKD 315
            .:|:.|.|.||:||.:.|...:..:|..:|.....|.||.::::..|::|....||: |....||
Human   199 EQVFEAALAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRD-LVDEAKD 262

  Fly   316 LTLHKCPGVKERTPNTTRMIFVAGGFFRHSLDILEAYNVDDMTWTTLANLRIPRSGLGAAFLKGK 380
              .|..|   ||.|:                  |.|:.......|::|               |.
Human   263 --YHLMP---ERRPH------------------LPAFRTRPRCCTSIA---------------GL 289

  Fly   381 FYAVGGRNN--NIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGGSAGMEY 443
            .|||||.|:  |..:....:.|:.:..:...|..|.||:..|.||||||::.|:||:||..|...
Human   290 IYAVGGLNSAANFYAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGYDGQLR 354

  Fly   444 HNTVEYYDPDLDRWTLVQPMHAKRLGV-----GVVVVNRLLYAIGGFDGNERLASVECYHPENNE 503
            .:|||.|:|:.|.||.|..|::||..|     |.||::..:|..||:|||..|:|||.|.||.::
Human   355 LSTVEAYNPETDTWTRVGSMNSKRSSVCFSAMGTVVLDGQIYVCGGYDGNSSLSSVETYSPETDK 419

  Fly   504 WSFLPPLQTGRSGAGV-----------------------------------------------AA 521
            |:.:..:.:.||.|||                                               |:
Human   420 WTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAAS 484

  Fly   522 INQYIYVVGGFDGTRQLATVERYDTENDTWDMVAPIQIARSALSLTPLDEKLYAIGGFDGNNFLS 586
            :...::|.||:||:..|:..|.|.:..|.|.::.|:...||.:||.....:|||:||:||.:.||
Human   485 LGSKMFVCGGYDGSGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLS 549

  Fly   587 IVEVYDPRTNTWTTGTPLKSGRSG 610
            .||:|||.|:.||...|:.....|
Human   550 SVEMYDPETDCWTFMAPMACHEGG 573

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Keap1NP_732202.2 PHA03098 92..599 CDD:222983 183/560 (33%)
KELCH repeat 369..416 CDD:276965 11/48 (23%)
KELCH repeat 420..463 CDD:276965 22/42 (52%)
KELCH repeat 467..510 CDD:276965 19/47 (40%)
KELCH repeat 514..558 CDD:276965 17/90 (19%)
KELCH repeat 561..606 CDD:276965 22/44 (50%)
KLHL18XP_005265058.2 BTB_POZ_KLHL18 19..134 CDD:349556 39/114 (34%)
PHA03098 34..562 CDD:222983 186/566 (33%)
BACK_KLHL18 135..241 CDD:350532 41/105 (39%)
KELCH repeat 282..327 CDD:276965 13/59 (22%)
KELCH repeat 331..374 CDD:276965 22/42 (52%)
KELCH repeat 378..427 CDD:276965 19/48 (40%)
KELCH repeat 430..474 CDD:276965 5/43 (12%)
KELCH repeat 477..521 CDD:276965 12/43 (28%)
KELCH repeat 524..567 CDD:276965 21/42 (50%)

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