DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Keap1 and Klhl17

DIOPT Version :9

Sequence 1:	NP_732202.2	Gene:	Keap1 / 42062	FlyBaseID:	FBgn0038475	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_938047.1	Gene:	Klhl17 / 231003	MGIID:	2678948	Length:	640	Species:	Mus musculus

Alignment Length:	654	Identity:	233/654 - (35%)
Similarity:	333/654 - (50%)	Gaps:	52/654 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQTQMHSP---MQYETHISDMPNHKGYP-----------CRPEEAEMSNTSESCS--ISCGGRFG 49
            ||.:...|   .|...|.|..|..:..|           .||.:|..:...|...  :|..|...
Mouse     1 MQPRGERPAGRTQSPEHSSPGPGPEAPPPPQPPAPEAERARPRQARPAAPMEGAMQLLSREGHSV 65

  Fly    50 SAHSTLDDHDATDDDMTFCMSNYAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPY 114
            :.:|....||                |...|..||..|:|.|:||.|..:...||||||::.|||
Mouse    66 AHNSKRHYHD----------------AFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPY 114

  Fly   115 FKAMFTGGLKESEMSRVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDAC 179
            |.||||..:.||..:.|.|..:.|.|:.:::.|.||.:|.|.|..|..|||||::.|:..|.|||
Mouse   115 FHAMFTNEMSESRQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDAC 179

  Fly   180 CAFLERQLDPTNAIGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDE 244
            |.||..||||:|.:||..||:.|.|.:|.|.|:.::.::|..|.:.|||:.|...|::.|:..|.
Mouse   180 CKFLLSQLDPSNCLGIRGFADTHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDS 244

  Fly   245 LNVQEEREVYNAVLKWVKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYL 309
            |||..|.:||.|||.|||:|.|.|...:..::..||...|:.:||...:....::|..|.|::.|
Mouse   245 LNVPSEEDVYRAVLSWVKHDVDTRRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLL 309

  Fly   310 AKIFKDLTLHKCPGV-------KERTPNTTRMIFVAGG---FFRHSLDILEAYNVDDMTWTTLAN 364
            .:..|...|.:..||       ..|......::|..||   |..|.  ..|||:.....|..:|:
Mouse   310 IEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHG--DCEAYDTRTDRWHVVAS 372

  Fly   365 LRIPRSGLGAAFLKGKFYAVGGRNNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVAVMD 429
            :...|:.:|.|.:..:.|||||.:   |:| |...|:.|..||.||:|...|...|..:|||.:.
Mouse   373 MSTRRARVGVAAVGNRLYAVGGYD---GTS-DLATVESYDPVTNTWQPEVSMGTRRSCLGVAALH 433

  Fly   430 ELMYAVGGSAGMEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLASV 494
            .|:||.||..|....|:.|.|||....||.:..|..:|..|.|..::..|||:||:|.:..||:|
Mouse   434 GLLYAAGGYDGASCLNSAERYDPLTGTWTSIAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLATV 498

  Fly   495 ECYHPENNEWSFLPPLQTGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWDMVAPIQI 559
            |.|.|:.|.|:.:..:.:.||.||||.:...:||.||.|||..|.:||||.|:...|:.|||:.|
Mouse   499 EKYEPQVNSWTPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSTKAGAWESVAPMNI 563

  Fly   560 ARSALSLTPLDEKLYAIGGFDGNNFLSIVEVYDPRTNTWTTGTPLKSGRSGHASAVI----YQPA 620
            .||...|..:|..|||:||.||::.|:.:|.|:||||.|...:.:.:.||....||:    :.|.
Mouse   564 RRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCMFTRRSSVGVAVLELLNFPPP 628

  Fly   621 CSTT 624
            .|.|
Mouse   629 SSPT 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	BTB	80..183	CDD:279045	47/102 (46%)
		PHA03098	92..599	CDD:222983	201/516 (39%)
		BACK	192..294	CDD:285009	38/101 (38%)
		Kelch	335..379	CDD:128874	13/46 (28%)
		KELCH repeat	369..416	CDD:276965	18/46 (39%)
		Kelch	382..430	CDD:128874	20/47 (43%)
		KELCH repeat	420..463	CDD:276965	17/42 (40%)
		Kelch	433..476	CDD:128874	16/42 (38%)
		KELCH repeat	467..510	CDD:276965	17/42 (40%)
		Kelch	478..523	CDD:128874	20/44 (45%)
		KELCH repeat	514..558	CDD:276965	23/43 (53%)
		Kelch_1	514..556	CDD:279660	21/41 (51%)
		KELCH repeat	561..606	CDD:276965	19/44 (43%)
		Kelch	572..616	CDD:128874	18/43 (42%)
Klhl17	NP_938047.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50		11/48 (23%)
		BTB_POZ_KLHL17_actinfilin	51..189	CDD:349555	58/153 (38%)
		PHA03098	90..556	CDD:222983	179/471 (38%)
		BACK	187..288	CDD:421692	40/100 (40%)
		Interaction with F-actin. /evidence=ECO:0000250	287..639		125/352 (36%)
		KELCH repeat	377..420	CDD:276965	18/46 (39%)
		KELCH repeat	424..468	CDD:276965	17/43 (40%)
		KELCH repeat	471..516	CDD:276965	17/44 (39%)
		KELCH repeat	518..562	CDD:276965	23/43 (53%)
		KELCH repeat	565..610	CDD:276965	19/44 (43%)
		Kelch	577..621	CDD:128874	19/43 (44%)
		Interaction with PDZK1. /evidence=ECO:0000250	638..640
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820