Protein Alignment Keap1 and Klhl17

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_938047.1
• Gene: Klhl17 / 231003
• MGIID: 2678948
• Length: 640
• Species: Mus musculus
• Alignment Length: 654
• Identity: 233/654 - (35%)
• Similarity: 333/654 - (50%)
• Gaps: 52/654 - (7%)

  Fly     1 MQTQMHSP---MQYETHISDMPNHKGYP-----------CRPEEAEMSNTSESCS--ISCGGRFG 49
            ||.:...|   .|...|.|..|..:..|           .||.:|..:...|...  :|..|...
Mouse     1 MQPRGERPAGRTQSPEHSSPGPGPEAPPPPQPPAPEAERARPRQARPAAPMEGAMQLLSREGHSV 65

  Fly    50 SAHSTLDDHDATDDDMTFCMSNYAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPY 114
            :.:|....||                |...|..||..|:|.|:||.|..:...||||||::.|||
Mouse    66 AHNSKRHYHD----------------AFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPY 114

  Fly   115 FKAMFTGGLKESEMSRVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDAC 179
            |.||||..:.||..:.|.|..:.|.|:.:::.|.||.:|.|.|..|..|||||::.|:..|.|||
Mouse   115 FHAMFTNEMSESRQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDAC 179

  Fly   180 CAFLERQLDPTNAIGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDE 244
            |.||..||||:|.:||..||:.|.|.:|.|.|:.::.::|..|.:.|||:.|...|::.|:..|.
Mouse   180 CKFLLSQLDPSNCLGIRGFADTHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDS 244

  Fly   245 LNVQEEREVYNAVLKWVKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYL 309
            |||..|.:||.|||.|||:|.|.|...:..::..||...|:.:||...:....::|..|.|::.|
Mouse   245 LNVPSEEDVYRAVLSWVKHDVDTRRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLL 309

  Fly   310 AKIFKDLTLHKCPGV-------KERTPNTTRMIFVAGG---FFRHSLDILEAYNVDDMTWTTLAN 364
            .:..|...|.:..||       ..|......::|..||   |..|.  ..|||:.....|..:|:
Mouse   310 IEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHG--DCEAYDTRTDRWHVVAS 372

  Fly   365 LRIPRSGLGAAFLKGKFYAVGGRNNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVAVMD 429
            :...|:.:|.|.:..:.|||||.:   |:| |...|:.|..||.||:|...|...|..:|||.:.
Mouse   373 MSTRRARVGVAAVGNRLYAVGGYD---GTS-DLATVESYDPVTNTWQPEVSMGTRRSCLGVAALH 433

  Fly   430 ELMYAVGGSAGMEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLASV 494
            .|:||.||..|....|:.|.|||....||.:..|..:|..|.|..::..|||:||:|.:..||:|
Mouse   434 GLLYAAGGYDGASCLNSAERYDPLTGTWTSIAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLATV 498

  Fly   495 ECYHPENNEWSFLPPLQTGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWDMVAPIQI 559
            |.|.|:.|.|:.:..:.:.||.||||.:...:||.||.|||..|.:||||.|:...|:.|||:.|
Mouse   499 EKYEPQVNSWTPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSTKAGAWESVAPMNI 563

  Fly   560 ARSALSLTPLDEKLYAIGGFDGNNFLSIVEVYDPRTNTWTTGTPLKSGRSGHASAVI----YQPA 620
            .||...|..:|..|||:||.||::.|:.:|.|:||||.|...:.:.:.||....||:    :.|.
Mouse   564 RRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCMFTRRSSVGVAVLELLNFPPP 628

  Fly   621 CSTT 624
            .|.|
Mouse   629 SSPT 632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	201/516 (39%)
		KELCH repeat	369..416	CDD:276965	18/46 (39%)
		KELCH repeat	420..463	CDD:276965	17/42 (40%)
		KELCH repeat	467..510	CDD:276965	17/42 (40%)
		KELCH repeat	514..558	CDD:276965	23/43 (53%)
		KELCH repeat	561..606	CDD:276965	19/44 (43%)
Klhl17	NP_938047.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..50		11/48 (23%)
		BTB_POZ_KLHL17_actinfilin	51..189	CDD:349555	58/153 (38%)
		PHA03098	90..556	CDD:222983	179/471 (38%)
		BACK	187..288	CDD:475122	40/100 (40%)
		Interaction with F-actin. /evidence=ECO:0000250	287..639		125/352 (36%)
		KELCH repeat	377..420	CDD:276965	18/46 (39%)
		KELCH repeat	424..468	CDD:276965	17/43 (40%)
		KELCH repeat	471..516	CDD:276965	17/44 (39%)
		KELCH repeat	518..562	CDD:276965	23/43 (53%)
		KELCH repeat	565..610	CDD:276965	19/44 (43%)
		Kelch	577..621	CDD:128874	19/43 (44%)
		Interaction with PDZK1. /evidence=ECO:0000250	638..640