Protein Alignment Keap1 and Klhl20

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_001034571.1
• Gene: Klhl20 / 226541
• MGIID: 2444855
• Length: 604
• Species: Mus musculus
• Alignment Length: 612
• Identity: 229/612 - (37%)
• Similarity: 329/612 - (53%)
• Gaps: 33/612 - (5%)

  Fly    27 RPEEAEMSNTSESCSISCGGRFGSAHSTLDDHDATDDD------MTFCMSNYAKEALKMMYMMRS 85
            ||.|..|..||.     |         ||.|.:...:.      |.:....:.::.|:::.::|.
Mouse     8 RPGETGMDVTSR-----C---------TLGDPNKLPEGVPQPARMPYISDKHPRQTLEVINLLRK 58

  Fly    86 HGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQLQGVCPTAMSRILYFMYT 150
            |..|.||||.|..:...||:|:|||.||||:|||||.|.||..:.|.::.:...||..::.|.||
Mouse    59 HRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYT 123

  Fly   151 GQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHFAEQHGCVELQKKANVFI 215
            .||.|.|..|..|||||.:.|:..:.:|||.||:|||||:|.:||..||:.|.|.||.:.|:.|.
Mouse   124 SQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAFADTHSCRELLRIADKFT 188

  Fly   216 ERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWVKYDEDNRHCKMEHILGAVR 280
            :.||.:|.:.|||:.|.|.|||.:|..|||||:.|.:|:|||:.||||....|..::..:|..||
Mouse   189 QHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVR 253

  Fly   281 CQFLTPNFLKEQMKNCDVLRKVPACREYL--AKIF----KDLTLHKCPGVKERTP-NTTRMIFVA 338
            ...|:|.||...:.:..:::....||:.:  ||.:    ::..|.:.|..:.|.| ....::|..
Mouse   254 LPLLSPKFLVGTVGSDPLIKSDEECRDLVDEAKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAV 318

  Fly   339 GGFFR-HSLDILEAYNVDDMTWTTLANLRIPRSGLGAAFLKGKFYAVGGRNNNIGSSYDSDWVDR 402
            ||:.. .::..:|.|:.....|..:|::...|.|:|.:.|....|||||.:   ||||.:. |:|
Mouse   319 GGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHD---GSSYLNS-VER 379

  Fly   403 YSAVTETW-RPCAPMSVPRHRVGVAVMDELMYAVGGSAGMEYHNTVEYYDPDLDRWTLVQPMHAK 466
            |...|..| ...||.|..|..|||||:...:|||||..|:...|.||.|||..::||.|..|..:
Mouse   380 YDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTR 444

  Fly   467 RLGVGVVVVNRLLYAIGGFDGNERLASVECYHPENNEWSFLPPLQTGRSGAGVAAINQYIYVVGG 531
            ||||.|.|:...|||:||.||...|.:||.|:|:.|.|..:.|:.|.|...|.|.....||.|||
Mouse   445 RLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGG 509

  Fly   532 FDGTRQLATVERYDTENDTWDMVAPIQIARSALSLTPLDEKLYAIGGFDGNNFLSIVEVYDPRTN 596
            .|.|.:|::.|||:...:.|..|..:...||.:.|..::.:|.|:|||||..:|..:||:||..|
Mouse   510 RDDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDAN 574

  Fly   597 TWTTGTPLKSGRSGHASAVIYQPACST 623
            ||.....:...|.|....||....|.:
Mouse   575 TWRLYGGMNYRRLGGGVGVIKMTHCES 601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	207/515 (40%)
		KELCH repeat	369..416	CDD:276965	19/47 (40%)
		KELCH repeat	420..463	CDD:276965	21/42 (50%)
		KELCH repeat	467..510	CDD:276965	20/42 (48%)
		KELCH repeat	514..558	CDD:276965	16/43 (37%)
		KELCH repeat	561..606	CDD:276965	18/44 (41%)
Klhl20	NP_001034571.1	BTB_POZ_KLHL20_KLEIP	40..167	CDD:349558	55/126 (44%)
		PHA03098	58..581	CDD:222983	211/526 (40%)
		Kelch 1	314..360		11/45 (24%)
		KELCH repeat	350..394	CDD:276965	19/47 (40%)
		Kelch 2	362..408		23/49 (47%)
		KELCH repeat	398..442	CDD:276965	21/43 (49%)
		Kelch 3	409..455		22/45 (49%)
		KELCH repeat	445..490	CDD:276965	21/44 (48%)
		Kelch 4	457..502		19/44 (43%)
		KELCH repeat	492..535	CDD:276965	16/42 (38%)
		Kelch 5	504..549		16/44 (36%)
		KELCH repeat	539..584	CDD:276965	18/44 (41%)
		Kelch 6	551..596		19/44 (43%)