Protein Alignment Keap1 and Gan

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_001074620.1
• Gene: Gan / 209239
• MGIID: 1890619
• Length: 597
• Species: Mus musculus
• Alignment Length: 574
• Identity: 160/574 - (27%)
• Similarity: 253/574 - (44%)
• Gaps: 66/574 - (11%)

  Fly    72 YAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMS--RVQLQ 134
            :|...|:.:...|......|..|.:..|..|..|.:|:|||||.:........:.:.|  :::|:
Mouse    12 HAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTYKIELE 76

  Fly   135 GVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHFA 199
            |:....|..||.::::||||:.|.|:..::.||.:..:.::...||.|||..:...|.|||..||
Mouse    77 GISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCIGIRDFA 141

  Fly   200 EQHGCV-ELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWVKY 263
             .|.|: .:...|..::|.:|..|...||||:||..:|..:|..::|||..||.|:.||::|:.:
Mouse   142 -LHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAH 205

  Fly   264 DEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKV-----------PACREYLAKIFKDLT 317
            |.:.|...|:.::.|:....|..::|:|||.|..::|::           |...|.:...||...
Mouse   206 DVEMRKVHMKDVMSALWVSGLDSSYLREQMLNEPLVREIVKECSNIPLSQPQQGEAMLASFKPRG 270

  Fly   318 LHKCPGVKERTPNTTRMIFVAGGFFRHSLDILEA-------YNVDDMTWTTLANLRIPRSGLGAA 375
            ..:|             |...||..|.|.....|       |:.:...|..||.|.:||...|..
Mouse   271 YSEC-------------IVTIGGEERVSRKPTAAMRCMCPLYDPNRQLWIELAPLSMPRINHGVL 322

  Fly   376 FLKGKFYAVGGRNNN-----IGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAV 435
            ..:|..:.:||::.|     .|..||.|        ..||....||...||..|:..:|.::|.:
Mouse   323 SAEGFLFVLGGQDENKQTLSSGEKYDPD--------ANTWTALPPMHEARHNFGIVEIDGMLYIL 379

  Fly   436 GGSAGMEYHNTVEYYDPDLDRWTLVQP--MHAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYH 498
            ||..|.....::|.||.....|| .||  ...:::|. ...:.:.:||:||....:...|||||.
Mouse   380 GGEDGDRELISMECYDIYSKTWT-KQPDLTMVRKIGC-YAAMKKKIYAMGGGSYGKLFESVECYD 442

  Fly   499 PENNEWSFLPPLQTGRSGAGVAAINQYIYVVGG------FDGTRQL-ATVERYDTENDTWDMVAP 556
            |...:|:.:.||:..|.||....:...:||.||      ..|:..: ...|.|..|...|..:..
Mouse   443 PRTQQWTAICPLKERRFGAVACGVAMELYVFGGVRSREDIQGSEMVTCKSEFYHDEFKRWIYLND 507

  Fly   557 IQIARSALS-----LTPLDEKLYAIGGFD-GNNFLSIVEVYDPRTNTWTTGTPL 604
            ..:...|.|     ..|:...:|.||..| |.|: ..|..:...|.||....||
Mouse   508 QNLCIPASSSFVYGAVPIGASIYVIGDLDTGTNY-DYVREFKRSTGTWHHTKPL 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	153/547 (28%)
		KELCH repeat	369..416	CDD:276965	12/51 (24%)
		KELCH repeat	420..463	CDD:276965	15/44 (34%)
		KELCH repeat	467..510	CDD:276965	12/42 (29%)
		KELCH repeat	514..558	CDD:276965	12/50 (24%)
		KELCH repeat	561..606	CDD:276965	15/50 (30%)
Gan	NP_001074620.1	BTB_POZ_KLHL16_gigaxonin	16..126	CDD:349554	30/109 (28%)
		PHA03098	28..502	CDD:222983	141/497 (28%)
		BACK_KLHL16_gigaxonin	130..226	CDD:350530	33/96 (34%)
		Kelch 1. /evidence=ECO:0000255	274..326		15/64 (23%)
		KELCH repeat	316..360	CDD:276965	12/51 (24%)
		Kelch 2. /evidence=ECO:0000255	327..374		14/54 (26%)
		KELCH repeat	364..408	CDD:276965	15/44 (34%)
		Kelch 3. /evidence=ECO:0000255	376..421		12/46 (26%)
		KELCH repeat	411..456	CDD:276965	14/45 (31%)
		Kelch 4. /evidence=ECO:0000255	422..468		16/45 (36%)
		KELCH repeat	458..511	CDD:276965	12/52 (23%)
		Kelch 5. /evidence=ECO:0000255	470..522		11/51 (22%)
		KELCH repeat	514..561	CDD:276965	15/48 (31%)
		Kelch 6. /evidence=ECO:0000255	528..574		12/34 (35%)