DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Keap1 and ivns-1

DIOPT Version :9

Sequence 1:	NP_732202.2	Gene:	Keap1 / 42062	FlyBaseID:	FBgn0038475	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_510109.1	Gene:	ivns-1 / 181410	WormBaseID:	WBGene00006493	Length:	817	Species:	Caenorhabditis elegans

Alignment Length:	752	Identity:	171/752 - (22%)
Similarity:	261/752 - (34%)	Gaps:	231/752 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 DATDDDMTFCMSNYAKEAL--KMMYMM------------------RSHGMLTDVVLEVK-KELFP 102
            |.||        |:.:|||  |..|.:                  |.:..|.|.||.|| :|:|
Worm    51 DETD--------NWGQEALDEKEAYTLMLRDPSIKNDLLDRLNTFRRNRELCDAVLFVKEREIF- 106

  Fly   103 AHKVVLSAASPYFKAMFTGGLKESEMSRVQLQGVCPTAMS------------------------- 142
            .|||||:|.||....||.   :|:|.|:.:..   ||:.|
Worm   107 VHKVVLAAVSPALLDMFN---EENESSQDEKS---PTSSSPTNGHTNGITNGNGEVAHENGAPVS 165

  Fly   143 -----------------------RILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLE 184
                                   .::.|.||..:.::...|.:|...|...|:..||.||.|:|.
Worm   166 AQKPQKSSTTFYEFSQTDFECFEALVNFAYTANLEISSRKVAELYKTAYALQMIPVIRACAAYLA 230

  Fly   185 RQLDPTNAIGIAHFAEQHGCVELQKKANVFIERNFTQVCQE-EEFLQLSAYQLIALIRRDELNVQ 248
            ..|..:|.|||...|..|....|..|.:.||..||..:..: :||.||...|:..::..::..|.
Worm   231 ENLQLSNCIGIRRQANFHNDTFLMGKVDQFIVDNFDSIVNDSKEFTQLPVIQVRIIVPAEDGKVT 295

  Fly   249 EEREVYNAVLKW-VKYDEDNRHCKMEHILGAVRCQ----FLTPNFL--------KEQMKNCDVL- 299
            ........:.:. :.|.::..|.:.||.:..:.|:    ::..|.|        :..:.:||::
Worm   296 NNANNNGGLAEMALFYFQNMPHDRAEHSIDLLTCKTHILYMEENHLADCIEMDERSSVGSCDIIQ 360

  Fly   300 --RKVPACREYLAK-------IFKDLTLHKCPGV------KERTPN---TTRMIFVAGGFFRHSL 346
              :|....|:.:||       |...:..|:..|.      ..|.||   :...:..||.......
Worm   361 DYKKSGKDRKDVAKAMTAQEPIINSVVQHRVNGAVPVRLNASRLPNMNASNESLESAGTDDSDPQ 425

  Fly   347 DILEA-----YNVDDMTWTTLANL----------------------------------------- 365
            |.:||     :......|..|..|
Worm   426 DTIEARLISTHQTAPQYWVALVVLYRRLCVLSLQLTDNEELLRTKREPCPVDSQKAALLSRLISC 490

  Fly   366 -----------RIPRSGLGAAFLKGKFYAVGGRNNNIGSSYDSDWVDRYSAVTETWRPCAPMSVP 419
                       ..||..:||:||.||.:..||.:.  |....|  |:.|..|...||..|.|...
Worm   491 TGKQQKPLECMSAPRCSIGASFLNGKIFVCGGYDR--GECLRS--VEEYDVVNGKWRNVAKMKAE 551

  Fly   420 RHRVGVAVMDELMYAVGGSAGMEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGG 484
            |.|....:....::||.||.|.....:.|.|||..|.|..:..:...|...|...::..:|.|||
Worm   552 RGRFDCTIHGGKVFAVAGSNGNNDLKSCEIYDPKADVWAPLPNLATARCHNGCATIDNYVYCIGG 616

  Fly   485 -FD---------------GNER------------------------------------LASVECY 497
             ||               |.|.                                    :.|||.:
Worm   617 SFDQKVLKDCERLDTTKLGTEEAEWEPMASMEHPRYQAGVCTWKGLVVAAGGCDRWTCMDSVEAF 681

  Fly   498 HPENNEWSFLPPLQTGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWDMVAPIQIAR- 561
            .|:.|.|..||.|:..|.|..||.:...:||:||.|||:.|.|||..|:.:..|.:...:...|
Worm   682 DPKTNAWRQLPKLRQARRGGAVAVVRDTLYVIGGHDGTQSLDTVEILDSPSSQWRVGPTLTTPRA 746

  Fly   562 SALSLTPLDEKLYAIGGFDGNNFLSIVEVYDPRTNTW 598
            :..::......::.||||:|..||..:|:.:.....|
Worm   747 NTHAVVTAGNVIFCIGGFNGVKFLDTIELLENEQIGW 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	BTB	80..183	CDD:279045	38/169 (22%)
		PHA03098	92..599	CDD:222983	159/699 (23%)
		BACK	192..294	CDD:285009	24/115 (21%)
		Kelch	335..379	CDD:128874	14/100 (14%)
		KELCH repeat	369..416	CDD:276965	17/46 (37%)
		Kelch	382..430	CDD:128874	13/47 (28%)
		KELCH repeat	420..463	CDD:276965	13/42 (31%)
		Kelch	433..476	CDD:128874	13/42 (31%)
		KELCH repeat	467..510	CDD:276965	18/94 (19%)
		Kelch	478..523	CDD:128874	21/96 (22%)
		KELCH repeat	514..558	CDD:276965	17/43 (40%)
		Kelch_1	514..556	CDD:279660	17/41 (41%)
		KELCH repeat	561..606	CDD:276965	10/39 (26%)
		Kelch	572..616	CDD:128874	9/27 (33%)
ivns-1	NP_510109.1	BTB_POZ	77..241	CDD:365784	41/170 (24%)
		PHA03098	183..735	CDD:222983	126/555 (23%)
		KELCH repeat	505..548	CDD:276965	17/46 (37%)
		KELCH repeat	552..596	CDD:276965	13/43 (30%)
		KELCH repeat	599..647	CDD:276965	10/47 (21%)
		KELCH repeat	651..695	CDD:276965	8/43 (19%)
		KELCH repeat	698..743	CDD:276965	17/44 (39%)
		Kelch_1	744..>774	CDD:366584	8/29 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820