Protein Alignment Keap1 and kel-3

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_499784.2
• Gene: kel-3 / 176775
• WormBaseID: WBGene00002185
• Length: 591
• Species: Caenorhabditis elegans
• Alignment Length: 584
• Identity: 187/584 - (32%)
• Similarity: 287/584 - (49%)
• Gaps: 39/584 - (6%)

  Fly    61 TDDDMTFCMSNYAKEALKMMYM----MRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTG 121
            ||||:.|...:...|..|..|.    :||...|.||.|.|:.....||||:|:|..|||:.|||.
 Worm    18 TDDDLDFIKVDILDEMYKKSYSIFNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTL 82

  Fly   122 GLKESEMSRVQLQ--GVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLE 184
            .|.|:.|..:.::  .:....:..:|.|.|||::|:|...|..::..|..||:..|:..|..||.
 Worm    83 DLMEANMKEINIEDSDMNYETVDALLSFAYTGELRITTSNVQSIMLGANFFQMLEVVQHCGNFLL 147

  Fly   185 RQLDPTNAIGIAHFAEQHGCVE--LQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNV 247
            .:|.|:||:.|..|.:.. |||  :.:..:.:|:::|..|.::|:|.:||....|.|:|.|.|.|
 Worm   148 TRLHPSNALSIREFCKMM-CVEEKITEMTDDYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYV 211

  Fly   248 QEEREVYNAVLKWVKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKI 312
            ..|.:||.|.::|:..|. .||.:...||..||...|:|.:|...:.:..:::|...||:.:.:.
 Worm   212 DSEEQVYVAAMEWLNCDV-IRHEQAAKILPCVRLPLLSPTYLSSIVASNPIIKKDIPCRDLIDEA 275

  Fly   313 FKDLTL----------HKCPGVKERTPNTTRMI---FVAGGFFRH---SLDILEAYNVDDMTWTT 361
             ||..|          .||      ||...:::   .||.|...|   |...:|.|:.....|:.
 Worm   276 -KDYHLLPDRRSLIKSFKC------TPRLCQIVPGLIVAIGGLMHQSQSKSSVEIYDPTSKKWSP 333

  Fly   362 LANLRIPRSGLGAAFLKGKFYAVGGRNNNIGSSYDS-DWVDRYSAVTETWRPCAPMSVPRHRVGV 425
            :..:...|:.:|.|..:.:.||:||.|..     |. |.|:::...|..|...:|::..|..:..
 Worm   334 IDGMVTLRTRVGVAVNQRQVYAIGGFNGQ-----DRLDLVEKFDYDTLKWTTLSPLTRKRSALAA 393

  Fly   426 AVMDELMYAVGGSAGMEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNER 490
            |.:...:|..||..|:...:::|.||.:.:.|....||...|...||.|:::.:|..||.||.:.
 Worm   394 AFVTNRLYVCGGYDGLHSLSSIEIYDINRNVWEAGPPMENMRSAAGVTVIDKHIYICGGHDGMQI 458

  Fly   491 LASVECYHPENNEWSFLPPLQTGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWDMVA 555
            .||||....||.:|..:|.:...|...|.|.....|||.||:|||..|.:||.||.....|..|:
 Worm   459 FASVERLDTENQQWERIPSMIQQRCRFGAATFKGKIYVAGGYDGTSFLKSVEVYDPVEKKWSPVS 523

  Fly   556 PIQIARSALSLTPLDEKLYAIGGFDGNNFLSIVEVYDPRTNTWTTGTPLKSGRSGHASAVIYQP 619
            |:.:.||.:||...:|.|:|:.||||.|.|..:|.||..|::||..|.|.....|....||..|
 Worm   524 PMNMRRSRVSLVSTNEGLFAVAGFDGENNLCSMEQYDDVTDSWTIATALTCHEGGVGVGVIPMP 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	167/527 (32%)
		KELCH repeat	369..416	CDD:276965	13/47 (28%)
		KELCH repeat	420..463	CDD:276965	10/42 (24%)
		KELCH repeat	467..510	CDD:276965	17/42 (40%)
		KELCH repeat	514..558	CDD:276965	19/43 (44%)
		KELCH repeat	561..606	CDD:276965	21/44 (48%)
kel-3	NP_499784.2	BTB_POZ	32..149	CDD:453885	40/116 (34%)
		PHA03098	51..568	CDD:222983	169/530 (32%)
		KELCH repeat	341..384	CDD:276965	13/47 (28%)
		KELCH repeat	388..431	CDD:276965	10/42 (24%)
		KELCH repeat	435..479	CDD:276965	17/43 (40%)
		KELCH repeat	482..527	CDD:276965	19/44 (43%)
		KELCH repeat	529..572	CDD:276965	20/42 (48%)