Protein Alignment Keap1 and F47D12.7

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_498380.1
• Gene: F47D12.7 / 175891
• WormBaseID: WBGene00018563
• Length: 579
• Species: Caenorhabditis elegans
• Alignment Length: 533
• Identity: 133/533 - (24%)
• Similarity: 208/533 - (39%)
• Gaps: 99/533 - (18%)

  Fly   105 KVVLSAASPYFKAMFTGGLKESEMS--RVQL-----------------QGVCPTAMSRILYFMYT 150
            :.:||..|.||:.:|:...::|..:  |::|                 ||:.|
 Worm    67 RYLLSFYSNYFRVLFSSKFRDSNSTTHRIRLISASDLHFLLTIPKAFEQGIKP------------ 119

  Fly   151 GQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHFA-EQHGCVELQKKANVF 214
               .:|.....:||..|...|:...:|.....:.:.|...|.|.|...| ..|..:.::...::.
 Worm   120 ---NITLQKAIELLEPAAFLQMSIALDYISDIICKNLTHENIIKIFRLALLYHTTLAVRVWRSMV 181

  Fly   215 IERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWVKYDEDNRHCKMEHILGAV 279
              |.|..:.....:|.|...:||.|:....||::.|.|. ..|:.|:|::...:..::
 Worm   182 --RKFQTLFATNVYLSLKENELIGLLTDKHLNLKSEDET-TVVVNWIKHNSPLQSDRL------- 236

  Fly   280 RCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFKDLTLHKCPGVKERTPNTTRMIFVAGGF-FR 343
             .||...||.:         |..|...:|..             ::.|.|....:.|  ||: .|
 Worm   237 -TQFAQRNFSR---------RPQPDATKYEV-------------IRTRQPMDAIVCF--GGWASR 276

  Fly   344 HSLDILEAYNVDDMTWTTL-ANLRIP---RSGLGAAFLKGKFYAVGGRNNNIGSSYDSDWVDRYS 404
            .....:|..|.....|.|. .|..||   |:..|...::.|....||          .|.:.::.
 Worm   277 GVAQKIEVCNTRSDRWQTCNFNYDIPNIHRAYHGIEVVEDKLIVYGG----------FDGIKQFQ 331

  Fly   405 AV------TETWRPCAPMSVPRHRVGVAVMDE-----LMYAVGGSAGMEYHNTVEYYDPDLDRWT 458
            ..      |:.||..|.|:..|..|..|.:::     |::|.||..|:....|.|.||...|:||
 Worm   332 TTVLFDLSTKEWRRGANMNDKRCYVTSARVNDSYGRPLVFACGGMNGVSRLKTAEMYDYRADQWT 396

  Fly   459 LVQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYHPENNEWSFLPP-LQTGRSG-AGVAA 521
            .|..|...|....||.::..:.|||||||.......|.|.|..:.|..|.. ::|.|:| ..|:.
 Worm   397 EVANMTQMRSDGAVVTIDNKIVAIGGFDGRNIHQGGEVYDPVLDLWHPLSSNMRTRRTGCTAVSI 461

  Fly   522 INQYIYVVGGFDGTRQLATVERYDTENDTWDMVAPIQIARSALSLTPLDE-KLYAIGGFDGNNFL 585
            :||...::|||:|.|:|.:.|.||.....|.....:|.|||..|...:|. .:|..|||||....
 Worm   462 MNQVCMIIGGFNGNRRLDSAEIYDMREGLWHPEPTLQTARSNFSACQMDTCYVYVAGGFDGQTTT 526

  Fly   586 SIVEVYDPRTNTW 598
            ...|..|.|:..|
 Worm   527 KESERLDLRSKMW 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	133/533 (25%)
		KELCH repeat	369..416	CDD:276965	10/52 (19%)
		KELCH repeat	420..463	CDD:276965	16/47 (34%)
		KELCH repeat	467..510	CDD:276965	15/43 (35%)
		KELCH repeat	514..558	CDD:276965	15/44 (34%)
		KELCH repeat	561..606	CDD:276965	14/39 (36%)
F47D12.7	NP_498380.1	PHA03098	44..554	CDD:222983	133/533 (25%)
		NanM	306..559	CDD:442289	75/244 (31%)
		KELCH repeat	306..349	CDD:276965	10/52 (19%)
		KELCH repeat	353..402	CDD:276965	16/48 (33%)
		KELCH repeat	405..447	CDD:276965	15/41 (37%)
		KELCH repeat	453..499	CDD:276965	15/45 (33%)
		KELCH repeat	501..545	CDD:276965	14/39 (36%)