DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Keap1 and kel-20

DIOPT Version :9

Sequence 1:	NP_732202.2	Gene:	Keap1 / 42062	FlyBaseID:	FBgn0038475	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_491322.2	Gene:	kel-20 / 172012	WormBaseID:	WBGene00020030	Length:	607	Species:	Caenorhabditis elegans

Alignment Length:	600	Identity:	207/600 - (34%)
Similarity:	312/600 - (52%)	Gaps:	29/600 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 SAHSTLDDHDATDDDMTFCMSNYAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPY 114
            ::|.:.|..::......:..|::|...|:.:..:::..:|.||.|....:...||:|||||.|||
Worm    16 TSHDSADMFESRKPQSKYKNSHFANSVLQQLGGLKNRDVLCDVTLICGWKRINAHRVVLSACSPY 80

  Fly   115 FKAMFTGGLKESEMSRVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDAC 179
            |.:|||..:.|..|..:.::.:.|..:..::.|.|||.|.:.:..|..:||||.:.|:..|..||
Worm    81 FLSMFTSQMAECYMREINMEEIEPPTLEALIEFCYTGAIAIDDSNVQDILPAACLLQIHEVQTAC 145

  Fly   180 CAFLERQLDPTNAIGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDE 244
            |.:|::||||:|.:||..||:.|.|.||...|:.|..:||::|..:|||..|:...|..:|:.|:
Worm   146 CDYLKKQLDPSNCLGIRAFADTHSCKELLSSADEFALKNFSRVIGKEEFQMLTVESLTTIIKSDK 210

  Fly   245 LNVQEEREVYNAVLKWVKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYL 309
            ||...|..|::||::||::|...|...:..:|..||....||.||...:....:::..||.|:.:
Worm   211 LNAASEELVFSAVIQWVRHDISKRKTHLSMLLSHVRLPLCTPKFLVSVVSEEILVKSDPASRDLV 275

  Fly   310 --AKIFKDLTLHK----CPGVKERTP-NTTRMIFVAGGFFRHSLDILEAYNVDDM----TWTTLA 363
              ||.:..|.:.:    .|..|.|.| ..:.:::..||:..... |.....:|.|    ||..:|
Worm   276 DEAKNYLLLPVERPNMQGPRTKPRKPLQGSEVLYAVGGWCSGDA-IASIERLDPMKGGTTWKCVA 339

  Fly   364 NLRIPRSGLGAAFLKGKFYAVGGRNNNIGSSYDSDWVDRYSAVTETW-RPCAPMSVPRHRVGVAV 427
            .:...|.|:|.|.|:...|||||.:   |.||.:. ::||..:|..| ...||.:..|..||||.
Worm   340 PMGKRRCGVGVAVLENLLYAVGGHD---GQSYLNS-IERYDPMTNQWSSDVAPTATCRTSVGVAA 400

  Fly   428 MDELMYAVGGSAGMEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLA 492
            .:..:|||||..|....:.||.|||..:.|..|..|..:||||.|.|||..:||:||.:|...|.
Worm   401 FNGSLYAVGGQDGESCLDVVEKYDPRKNEWAKVASMGTRRLGVSVSVVNGCIYAVGGSNGPAPLN 465

  Fly   493 SVECYHPENNEWSFLPPLQTGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWDMVAPI 557
            :||.|.|...:|..:.|:.|.|...|.|..:.|||.|||.|.|.:|.|.|||..|.|.|..|..:
Worm   466 TVERYDPRVGKWEEVRPMLTKRKHLGTAVYDGYIYAVGGRDTTTELNTAERYSVERDEWQPVVAM 530

  Fly   558 QIARSALSLTPLDEKLYAIGGFDGNNFLSIVEVYDPRTNTWTTGTPLKSGRSGHASAVIYQPACS 622
            ...||.:.:..:.|||||:|||||..:|..||::|..||.|.|.:.:...|.|....|:
Worm   531 SNRRSGVGVAVVGEKLYAVGGFDGQTYLKSVEIFDKDTNRWKTHSQMFYRRLGGGVGVV------ 589

  Fly   623 TTFMDYEDSDAPHPD 637
                  ..:|||..:
Worm   590 ------RVADAPETE 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	BTB	80..183	CDD:279045	36/102 (35%)
		PHA03098	92..599	CDD:222983	192/518 (37%)
		BACK	192..294	CDD:285009	37/101 (37%)
		Kelch	335..379	CDD:128874	13/47 (28%)
		KELCH repeat	369..416	CDD:276965	18/47 (38%)
		Kelch	382..430	CDD:128874	19/48 (40%)
		KELCH repeat	420..463	CDD:276965	18/42 (43%)
		Kelch	433..476	CDD:128874	20/42 (48%)
		KELCH repeat	467..510	CDD:276965	19/42 (45%)
		Kelch	478..523	CDD:128874	16/44 (36%)
		KELCH repeat	514..558	CDD:276965	20/43 (47%)
		Kelch_1	514..556	CDD:279660	20/41 (49%)
		KELCH repeat	561..606	CDD:276965	20/44 (45%)
		Kelch	572..616	CDD:128874	19/43 (44%)
kel-20	NP_491322.2	PHA03098	56..572	CDD:222983	193/520 (37%)
		KELCH repeat	345..389	CDD:276965	18/47 (38%)
		KELCH repeat	393..437	CDD:276965	18/43 (42%)
		KELCH repeat	440..485	CDD:276965	20/44 (45%)
		KELCH repeat	487..531	CDD:276965	20/43 (47%)
		KELCH repeat	534..577	CDD:276965	20/42 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820