DRSC/TRiP Functional Genomics Resources

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Protein Alignment Keap1 and Enc1

DIOPT Version :10

Sequence 1:NP_732202.2 Gene:Keap1 / 42062 FlyBaseID:FBgn0038475 Length:776 Species:Drosophila melanogaster
Sequence 2:NP_031956.3 Gene:Enc1 / 13803 MGIID:109610 Length:589 Species:Mus musculus


Alignment Length:568 Identity:169/568 - (29%)
Similarity:262/568 - (46%) Gaps:53/568 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    67 FCMSNYAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRV 131
            |..|:||...|..:.::|...:.|||:|......||.|:.||:|.|.||:|||:||||||:.|.|
Mouse    23 FHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDSEV 87

  Fly   132 QL-QGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGI 195
            .. ..:.|..:..:|.:.|:.::.:.|.....||.|..|.:..::.|||..|||:.|.|||.:|:
Mouse    88 NFDNSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGM 152

  Fly   196 AHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKW 260
            ...::.|.|.:|.:.:......||..:.:.|:||||....::.|:..:||..::||.||.:.:.|
Mouse   153 LLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETEDERLVYESAMNW 217

  Fly   261 VKYDEDNRHCKMEHILGAVRCQFLTPNFLKE----------QMKNCDVLRKVPACREYLAKIFKD 315
            :.||...|:|.:..:|..||...|...:|.|          |.|:.:::.:...|:   .||.::
Mouse   218 ISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKSKEIVEEAIRCK---LKILQN 279

  Fly   316 --LTLHKCPGVKERTPNTTRMIFVAGG--FFRHSLDILEAYNVDDMTWTTL--ANLRIPRSGLGA 374
              :....|    .|...|...:|:.||  |....|     |.||......:  |::..||....|
Mouse   280 DGVVTSLC----ARPRKTGHALFLLGGQTFMCDKL-----YLVDQKAKEIIPKADIPSPRKEFSA 335

  Fly   375 AFLKGKFYAVGGRNNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGG-- 437
            ..:..|.|..|||.:..|.|.|. ||  |..:.|.|...|||.|.|...|.|.:...:|.|||  
Mouse   336 CAIGCKVYITGGRGSENGVSKDV-WV--YDTLHEEWSKAAPMLVARFGHGSAELKHCLYVVGGHT 397

  Fly   438 ----------SAGMEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFD-GNERL 491
                      |..::   .||.|||..::||:|.|:........||.....|:|.||.. .:::|
Mouse   398 AATGCLPASPSVSLK---QVEQYDPTTNKWTMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHDKL 459

  Fly   492 ASVECYHPENNEWSFLPPL--QTGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWDMV 554
            ..|:||....|.|| :|..  |..|..|.....|| |:::|| |......:..::::|...|..|
Mouse   460 PKVQCYDQCENRWS-VPATCPQPWRYTAAAVLGNQ-IFIMGG-DTEFSACSAYKFNSETYQWTKV 521

  Fly   555 APIQIARSALSLTPLDEKLYAIGGFDGNNFLSIVEVYDPRTNTWTTGT 602
            ..:...|.:........|||.:||:.|......::.|||..:.|.:.|
Mouse   522 GDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDVWNSIT 569

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Keap1NP_732202.2 PHA03098 92..599 CDD:222983 159/538 (30%)
KELCH repeat 369..416 CDD:276965 16/46 (35%)
KELCH repeat 420..463 CDD:276965 16/54 (30%)
KELCH repeat 467..510 CDD:276965 14/43 (33%)
KELCH repeat 514..558 CDD:276965 11/43 (26%)
KELCH repeat 561..606 CDD:276965 12/42 (29%)
Enc1NP_031956.3 BTB_POZ_KLHL37_ENC1 6..152 CDD:349576 48/128 (38%)
PHA03098 48..566 CDD:222983 159/538 (30%)
BACK_KLHL37_ENC1 145..242 CDD:350590 29/96 (30%)
Kelch 1 296..340 12/48 (25%)
KELCH repeat 330..374 CDD:276965 16/46 (35%)
Kelch 2 341..388 20/49 (41%)
KELCH repeat 378..431 CDD:276965 17/55 (31%)
Kelch 3 389..444 16/57 (28%)
KELCH repeat 434..480 CDD:276965 14/46 (30%)
Kelch 4 446..492 15/46 (33%)
Kelch 5 494..538 8/44 (18%)
KELCH repeat 528..568 CDD:276965 11/39 (28%)
Kelch 6 539..585 11/31 (35%)

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