Protein Alignment Keap1 and LOC1281663

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: XP_061497908.1
• Gene: LOC1281663 / 1281663
• VectorBaseID: AGAMI1_004119
• Length: 675
• Species: Anopheles gambiae
• Alignment Length: 649
• Identity: 229/649 - (35%)
• Similarity: 328/649 - (50%)
• Gaps: 59/649 - (9%)

  Fly    33 MSNTSESCSISCGGRFGSAHS------TLDDH-------DATDDDMTFCMSNYAKEALKMMYMMR 84
            |||     .:||.|...|:.|      |.:.|       .:...|..|...:::...||.|....
Mosquito     1 MSN-----ELSCKGSPTSSASVRASLVTDESHFSLASLNSSVSQDEFFRCRDHSDVVLKRMQDYL 60

  Fly    85 SHGMLTDVVL--EVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQLQGVCPTAMSRILYF 147
            ....|.||||  .|.....|||::||||:|.||.|||||.|:||:...:.||.|...|::.::.:
Mosquito    61 QSEKLCDVVLIAGVDGRRIPAHRLVLSASSAYFSAMFTGQLRESQQEEITLQEVSGDALNSLIQY 125

  Fly   148 MYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHFAEQHGCVELQKKAN 212
            .|||.|.:.|.||..||..|.:.|:..::.|||.||.|||.|:|.:|.:.||||.||..|.|.|.
Mosquito   126 CYTGAIEIREDTVETLLATACLLQLSTIVGACCNFLARQLHPSNCLGFSLFAEQQGCTALLKLAT 190

  Fly   213 VFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWVKYDEDNRHCKMEHILG 277
            .:..::|.||.:.:||..|.|.||..|:|.|:|||..|:||::|::.|::||.:.|...:..:|.
Mosquito   191 AYTCQHFQQVWKNQEFFMLDAAQLANLLRSDDLNVPNEQEVFHALMAWIQYDAEGRKRHIPELLA 255

  Fly   278 AVRCQFLTPNFLKEQMKN-CDVLRKVPACREYLAKIFKDLTLHKCPGVK-----ERT-PNTTRM- 334
            .::...|.|:|:.:.::. |....:   |::.:.:.||   .|..||.:     .|| |..:.|
Mosquito   256 LIKLPLLQPSFIVDHVEALCGGANE---CQQLVMEAFK---WHLIPGRRSLISTSRTRPRKSTMG 314

  Fly   335 -IFVAGGFFRHSLDI-LEAYNVDDMTWTTLANLRIPRSGLGAAFLKGKFYAVGGRNN----NIGS 393
             :...||...|...| :|:|:.....||.|.|:...|...|.|.|..|...||||:.    |...
Mosquito   315 RLLAVGGMDGHKGAISIESYDPRLDKWTLLKNMPTRRLQFGVAVLDDKLIIVGGRDGLKTLNTVD 379

  Fly   394 SYDSDWVDRYSAVTETWRPCA-PMSVPRHRVGVAVMDELMYAVGGSAGMEYHNTVEYYDPDLDRW 457
            |:|.:        |..|.... ||..|||.:|||.::..:|||||..|..|.||||.:||....|
Mosquito   380 SFDLN--------TMCWSTLVPPMGTPRHGLGVAFLEGPLYAVGGHDGWSYLNTVERWDPSARTW 436

  Fly   458 TLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYHPENNEWSFLPPLQTGRSGAGVAAI 522
            :.|.||.|.|...||.|:...||.|||.||:....:||||.|..|:|:...|:...|...||..:
Mosquito   437 SYVAPMSAMRSTAGVAVLGGRLYVIGGRDGSVCHRTVECYDPHTNKWTLRAPMNQRRGCVGVGVL 501

  Fly   523 NQYIYVVGGFD------GTRQLATVERYDTENDTWDMVAPIQIARSALSLTPLDEKLYAIGGFDG 581
            |.::|.:||.|      ...:..||||||...|||.::|.:.:.|.|:.::.|.:.|.|:||:||
Mosquito   502 NGFLYALGGHDCPPSNPAVCRTDTVERYDPTTDTWTLIASLSVGRDAIGVSVLGDWLVALGGYDG 566

  Fly   582 NNFLSIVEVYDPRTNTWTTGTPLKSGRSGHASAVI----YQPACSTTFMDYEDSDAPHPDGSNN 641
            ..:|.|||.||..||.||...|:...|:|.....|    ..||.:|..:....:.|.:|...||
Mosquito   567 IQYLKIVEQYDAETNEWTPIAPVNYSRAGACVVAIPNSFSNPASTTGGVALPSTSAANPSSPNN 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	199/529 (38%)
		KELCH repeat	369..416	CDD:276965	14/51 (27%)
		KELCH repeat	420..463	CDD:276965	20/42 (48%)
		KELCH repeat	467..510	CDD:276965	18/42 (43%)
		KELCH repeat	514..558	CDD:276965	18/49 (37%)
		KELCH repeat	561..606	CDD:276965	20/44 (45%)
LOC1281663	XP_061497908.1	None