Protein Alignment Keap1 and KLHDC7A

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_689588.2
• Gene: KLHDC7A / 127707
• HGNCID: 26791
• Length: 777
• Species: Homo sapiens
• Alignment Length: 450
• Identity: 107/450 - (23%)
• Similarity: 163/450 - (36%)
• Gaps: 132/450 - (29%)

  Fly   303 PACREYLAKIFKDLTLHKCPGVKERTPNTTRMIFVAGGFFRHSLDILE--AYNVDDMTWTTLANL 365
            |..|..|...::.|||.|                      |.:|:.|:  ||.|  |:...|..|
Human   426 PQVRLDLGNCYEVLTLAK----------------------RQNLEALKEAAYKV--MSENYLQVL 466

  Fly   366 RIP----------RSGLGAAFLKGKFYAVGGRNNNIGSSYDSDWVDRYSAVTETWRPCA---PMS 417
            |.|          |..:....|:|:.|.|..   ::....||..:..|....:.|||.|   |.:
Human   467 RSPDIYGCLSGAERELILQRRLRGRQYLVVA---DVCPKEDSGGLCCYDDEQDVWRPLARMPPEA 528

  Fly   418 VPRHRVGVAV--MDELMYAVGGSAGMEYH--NTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRL 478
            |.|   |.|:  :...::.|.|..|..:.  :.|..|:|....|:.|.|::..|....:|.::..
Human   529 VSR---GCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIWSEVCPLNQARPHCRLVALDGH 590

  Fly   479 LYAIGGFDGNERLASVECYHPENNEWSFLPPLQTGRSG-AGVAAIN-QYIYVVGGFDGTRQLATV 541
            ||||||    |.|.|||.|.|..:.|.|.|||.:.... |..|.:. :.|:|.||  ..|.|  :
Human   591 LYAIGG----ECLNSVERYDPRLDRWDFAPPLPSDTFALAHTATVRAKEIFVTGG--SLRFL--L 647

  Fly   542 ERYDTENDTWDMVAPIQIARSALSLTPLDEKLYAIGG----FDGNNFLSIVEVY--DPRTNTWTT 600
            .|:..:...| ...|...::...:      ::.|:.|    ||.|..|.|. ||  ...|..|
Human   648 FRFSAQEQRW-WAGPTGGSKDRTA------EMVAVNGFLYRFDLNRSLGIA-VYRCSASTRLW-- 702

  Fly   601 GTPLKSGRSGHASAVIYQPACSTTFMDYEDSDAPHPDGSNNGERNAHTPQNTYGSGSPHYPGTAS 665
                            |:  |:|    |.   .|:||.                    .......
Human   703 ----------------YE--CAT----YR---TPYPDA--------------------FQCAVVD 722

  Fly   666 NMQFHTSYGMSGCNNCDSEMDIKP-YIPAEHHSFQ------IPAIRSEELVNPNCPWSRM 718
            |:.:......:.|...||   :.| ::|.|..||.      :|.:.:  |..|:.|.:|:
Human   723 NLIYCVGRRSTLCFLADS---VSPRFVPKELRSFPAPQGTLLPTVLT--LPTPDLPQTRV 777

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	85/322 (26%)
		KELCH repeat	369..416	CDD:276965	12/49 (24%)
		KELCH repeat	420..463	CDD:276965	11/46 (24%)
		KELCH repeat	467..510	CDD:276965	18/42 (43%)
		KELCH repeat	514..558	CDD:276965	11/45 (24%)
		KELCH repeat	561..606	CDD:276965	11/50 (22%)
KLHDC7A	NP_689588.2	BACK_KBTBD11_CMLAP	430..505	CDD:350559	21/101 (21%)
		NanM	510..729	CDD:442289	69/284 (24%)
		KELCH repeat	531..575	CDD:276965	11/46 (24%)
		KELCH repeat	579..619	CDD:276965	19/43 (44%)