Protein Alignment Keap1 and KLHL18

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: XP_061510981.1
• Gene: KLHL18 / 1270785
• VectorBaseID: AGAMI1_005319
• Length: 624
• Species: Anopheles gambiae
• Alignment Length: 618
• Identity: 209/618 - (33%)
• Similarity: 317/618 - (51%)
• Gaps: 47/618 - (7%)

  Fly    36 TSESCSIS---------CGGRFGSAHST--LDDHDA----TDDD--MTFCMSNYAKEALKMMYMM 83
            |.|.|..|         .||. |:|.|:  ::...|    |:|:  |.|........:...|..:
Mosquito    17 TVERCDCSRKVVAVGTGSGGT-GTAGSSKMIEMQPAELSETEDNSYMYFRQEGLFANSFPKMKEI 80

  Fly    84 RSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQLQGVCPTAMSRILYFM 148
            |..|.|.||.|:|....|.||::||:|..|||.||||..:.||.:..:.::.:.|.|:..::.|.
Mosquito    81 RRMGKLCDVTLKVDSHSFSAHRIVLAATIPYFYAMFTHNMAESRIKEITMKEIEPMALESLINFA 145

  Fly   149 YTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHFAEQHGCVELQKKANV 213
            |:|.:::....|..|:..|:..|:..|.|||..||:|:..|.|.:||..||:..||.:|...|:.
Mosquito   146 YSGLVKIDTQNVQSLMVGASFLQLNEVRDACAKFLKRKFHPQNVLGIRQFADTLGCSKLIVSADR 210

  Fly   214 FIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWVKYDEDNRHCKMEHILGA 278
            :|.::|::|...:||:.||..:||.:|.||||||:.|..::.|.::|||:::::|...:..||..
Mosquito   211 YIHQHFSKVAAGDEFVALSYSELIDVIGRDELNVKSEECIFEACMRWVKHEQESRSEYLPLILAN 275

  Fly   279 VRCQFLTPNFLKEQMKNCDVLRKVPACREYL--AKIFKDLTLHKCPGVKERTP--NTTR------ 333
            :|...|:|.||.:.:...::::....||:.|  |:.|     |..|   ||..  :|||
Mosquito   276 IRLPLLSPQFLADSVATEELIKTSHKCRDLLDEARDF-----HLMP---ERRALVSTTRTRPRCF 332

  Fly   334 -----MIFVAGGFFRH--SLDILEAYNVDDMTWTTLANLRIPRSGLGAAFLKGKFYAVGGRNNNI 391
                 :||..||..::  |:..:|.||.....|:....:.:.||.:|.|...||.||.||.|...
Mosquito   333 DFVVGLIFAVGGLTKNGESVSTVEIYNPATKEWSMGEAMTMLRSRVGVAVTNGKLYAFGGFNGTE 397

  Fly   392 GSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGGSAGMEYHNTVEYYDPDLDR 456
            ..|    .|:.|......|.....|...|..||||.:::.:|..||..|:...:|||.|.|..|.
Mosquito   398 RLS----TVEIYDPRKHRWSQGTAMRCKRSAVGVAALEDYVYVCGGYDGVTSLSTVERYCPKTDG 458

  Fly   457 WTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYHPENNEWSFLPPLQTGRSGAGVAA 521
            |:.|.||...|...||..:...:||:||.||.....:||.|.|.::.|:.:..:...|...|||.
Mosquito   459 WSTVAPMMKYRSAGGVAALGGYVYALGGHDGLSIFDTVERYDPFSDTWTKVVSMLNRRCRLGVAT 523

  Fly   522 INQYIYVVGGFDGTRQLATVERYDTENDTWDMVAPIQIARSALSLTPLDEKLYAIGGFDGNNFLS 586
            :...:|..||:||...|.:||.||...::|.::||:.:.||.::|.....||:||||:||.:.||
Mosquito   524 LGNKLYACGGYDGNSFLRSVEVYDPVKNSWSLIAPMNVKRSRVALAANMGKLWAIGGYDGESNLS 588

  Fly   587 IVEVYDPRTNTWTTGTPLKSGRSGHASAVIYQP 619
            .||||||:|||||...|:|....|....||..|
Mosquito   589 TVEVYDPKTNTWTFVAPMKHHGGGVGCGVIPTP 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	182/523 (35%)
		KELCH repeat	369..416	CDD:276965	15/46 (33%)
		KELCH repeat	420..463	CDD:276965	17/42 (40%)
		KELCH repeat	467..510	CDD:276965	14/42 (33%)
		KELCH repeat	514..558	CDD:276965	17/43 (40%)
		KELCH repeat	561..606	CDD:276965	25/44 (57%)
KLHL18	XP_061510981.1	None