Protein Alignment Keap1 and KLHL29

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_443152.1
• Gene: KLHL29 / 114818
• HGNCID: 29404
• Length: 875
• Species: Homo sapiens
• Alignment Length: 616
• Identity: 170/616 - (27%)
• Similarity: 266/616 - (43%)
• Gaps: 73/616 - (11%)

  Fly    28 PEEAEMSNTSESCSISCGG--RFGSAHST-------LDDHDATDDDMTFCMSNYAKEALKMMYMM 83
            |..|:.|.|..|.:.:..|  ...|||..       :..::.||       ..:.:|.||.:...
Human   265 PPPAQPSATLPSGAPATNGPPTTDSAHGLQMLRTIGVGKYEFTD-------PGHPREMLKELNQQ 322

  Fly    84 RSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKES-----EMSRVQLQGVCPTAMSR 143
            |.....||:.:.|:...|..|:.||::.|.|||.:....:::|     |...:.|..:....:..
Human   323 RRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLELVLSNLQADVLEL 387

  Fly   144 ILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHFAEQHGCVELQ 208
            :|.|:|||.:.:.......||.||:.||.......|.:|||:||..:|.:|:...||...|.||.
Human   388 LLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGVLAMAEAMQCSELY 452

  Fly   209 KKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWVKYDEDNRHCKME 273
            ..|..|..:.|.:|..:||.|.:|....||.:..|.||.:.|..||..|:||:|.|...|.....
Human   453 HMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAA 517

  Fly   274 HILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYL--AKIFKDLTLHKCPGVKE--RTPNTTR- 333
            .:|..||..|:.|::|...:.|.::::...|||:.:  ||.:     |..|..::  :||.|..
Human   518 ELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKRY-----HMLPHARQEMQTPRTRPR 577

  Fly   334 --------MIFVAG----GFFRHSLDILEAYNVDDMTWTTLANLRIPRSGLGAAFLKGKFYAVGG 386
                    ::.|.|    |..:.||..:..:|..:..|..||:|         .|...:|::|..
Human   578 LSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASL---------PFYDREFFSVVS 633

  Fly   387 RNNNI--------GSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVG--GSAGM 441
            ..:||        |.:....|.  |.::.:.|...:.|:|||.|....|.|..:|.:|  |.||.
Human   634 AGDNIYLSGGMESGVTLADVWC--YMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGN 696

  Fly   442 EYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLASV-ECYHPENNEWS 505
            ..|  ||.||...::|..|.|:..........|....:|..||.:...|.|.| :.|.|:.|.||
Human   697 VDH--VERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWS 759

  Fly   506 FLPPLQTGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWDMVAPIQIARSALSLTPLD 570
            |:.........|....:|.:::::||  ...:..|:  ||.|.........:..:|...|...||
Human   760 FIESPMIDNKYAPAVTLNGFVFILGG--AYARATTI--YDPEKGNIKAGPNMNHSRQFCSAVVLD 820

  Fly   571 EKLYAIGGFDGNN--FLSIVEVYDPRTNTWT 599
            .|:||.||...:.  .|..:|.|:|.|||||
Human   821 GKIYATGGIVSSEGPALGNMEAYEPTTNTWT 851

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	151/541 (28%)
		KELCH repeat	369..416	CDD:276965	9/54 (17%)
		KELCH repeat	420..463	CDD:276965	16/44 (36%)
		KELCH repeat	467..510	CDD:276965	13/43 (30%)
		KELCH repeat	514..558	CDD:276965	8/43 (19%)
		KELCH repeat	561..606	CDD:276965	18/41 (44%)
KLHL29	NP_443152.1	PHA03247	<50..290	CDD:223021	6/24 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	115..145
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	248..291		7/25 (28%)
		BTB_POZ	312..438	CDD:453885	36/125 (29%)
		PHA03098	333..860	CDD:222983	153/541 (28%)
		BACK_KLHL29_KBTBD9	432..533	CDD:350543	34/100 (34%)
		KELCH repeat	577..621	CDD:276965	9/43 (21%)
		Kelch 1	585..635		13/58 (22%)
		KELCH repeat	626..669	CDD:276965	8/44 (18%)
		Kelch 2	637..683		12/47 (26%)
		KELCH repeat	673..716	CDD:276965	16/44 (36%)
		Kelch 3	684..730		14/47 (30%)
		KELCH repeat	720..808	CDD:276965	21/91 (23%)
		Kelch 4	732..778		13/45 (29%)
		Kelch 5	779..821		9/45 (20%)
		KELCH repeat	811..857	CDD:276965	18/41 (44%)
		Kelch 6	822..870		14/30 (47%)