Protein Alignment Keap1 and KLHL32

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_443136.2
• Gene: KLHL32 / 114792
• HGNCID: 21221
• Length: 620
• Species: Homo sapiens
• Alignment Length: 683
• Identity: 160/683 - (23%)
• Similarity: 277/683 - (40%)
• Gaps: 137/683 - (20%)

  Fly    68 CMS-NYAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRV 131
            |.| ::....|..:...||.|:|.|:.|..:::.|.|||.||:|.|.||:|||:..:.||....|
Human    19 CHSESHNDSVLAALNQQRSDGILCDITLIAEEQKFHAHKAVLAACSDYFRAMFSLCMVESGADEV 83

  Fly   132 QLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIA 196
            .|.||....:.:.|.|.|||||.:....:..:|.|.:..|:..:::.|..:|.::|:..|.:.:.
Human    84 NLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFNYLDLY 148

  Fly   197 HFAEQHGCVELQKKANVFIERNFTQVCQE--EEFLQLSAYQLIALIRRDELNVQEEREVYNAVLK 259
            ..|:......|:|....|:.::.:::.:.  ||.|.|....|..:::.|.|....|.:::...::
Human   149 RLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVR 213

  Fly   260 WVKYDEDNRHCK-MEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFKDLTLHKCPG 323
            |:   |.|.|.: |:.:|          .:::..:.:.|.|..|......:
Human   214 WL---EHNCHYQYMDELL----------QYIRFGLMDVDTLHTVALSHPLV-------------- 251

  Fly   324 VKERTPNTTRMIFVAGGFFRHSLDILEAYNVDDMTWTTLANLRIPRSGLGAAFLKGKFYAVGGRN 388
              :.:...|.::       ..:|:..::.....: |.|....  ||      |.....|.:||:.
Human   252 --QASETATALV-------NEALEYHQSIYAQPV-WQTRRTK--PR------FQSDTLYIIGGKK 298

  Fly   389 NNIGSSYDSDW---VDRYSAV---TETWRPCAPMSVPRHRVGVAVMDELMYAVGGSAGMEYHN-- 445
            ..:....:..:   ||:.:|:   ...|...|||.|.|....||||.:.::..||.  :|:.:
Human   299 REVCKVKELRYFNPVDQENALIAAIANWSELAPMPVGRSHHCVAVMGDFLFVAGGE--VEHASGR 361

  Fly   446 -----TVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNER---LASVECYHPENN 502
                 |...|||..:.|..:.||...|....:..:...|||:||  .||.   |.:||.|.|:.|
Human   362 TCAVRTACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGG--RNELRQVLPTVERYCPKKN 424

  Fly   503 EWSFLPPLQTGRS-GAGVAAINQYIYVVGGFDGTRQLAT-VERYDTENDTWDMVAPIQIARSALS 565
            :|:|:.......| .||..| :..:::.||...|.|... :..|:...:.|...:|:...|...|
Human   425 KWTFVQSFDRSLSCHAGYVA-DGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHS 488

  Fly   566 LTPLDEKLYAIGG--FDGNN---FLSIVEVYDPRTNTWT------------TGTPLKSGR---SG 610
            :..:..|||.:||  .|.||   .:..::.|:..|:.||            :|..:.:||   .|
Human   489 MAAVQRKLYVLGGNDLDYNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVHNGRIYLVG 553

  Fly   611 HASAVIYQP-ACSTTFMDYEDSDAPHPDGSNNGERNAHTPQNTYGSGSPHYPGTASNMQFHTSYG 674
            ..|....:| ||....           |.|..|:....     ||...|.    |||       |
Human   554 GYSIWTNEPLACIQVL-----------DVSREGKEEVF-----YGPTLPF----ASN-------G 591

  Fly   675 MSGCNNCDSEMDIKPYIPAEH------HSFQIP 701
            ::.|           ::||.:      .:.|:|
Human   592 IAAC-----------FLPAPYFTCPNLQTLQVP 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	127/532 (24%)
		KELCH repeat	369..416	CDD:276965	10/52 (19%)
		KELCH repeat	420..463	CDD:276965	13/49 (27%)
		KELCH repeat	467..510	CDD:276965	16/45 (36%)
		KELCH repeat	514..558	CDD:276965	11/45 (24%)
		KELCH repeat	561..606	CDD:276965	15/61 (25%)
KLHL32	NP_443136.2	BTB_POZ_KLHL32	14..146	CDD:349570	42/126 (33%)
		BACK_KLHL32_BKLHD5	139..236	CDD:350546	20/109 (18%)
		Kelch 1	290..346		16/55 (29%)
		Kelch	291..346	CDD:128874	16/54 (30%)
		NanM	324..595	CDD:442289	79/302 (26%)
		KELCH repeat	336..384	CDD:276965	13/49 (27%)
		Kelch 2	347..398		11/52 (21%)
		KELCH repeat	388..433	CDD:276965	16/46 (35%)
		Kelch 3	399..446		19/49 (39%)
		KELCH repeat	436..482	CDD:276965	11/46 (24%)
		Kelch 4	447..494		9/46 (20%)
		KELCH repeat	484..534	CDD:276965	14/49 (29%)
		Kelch 5	496..547		12/50 (24%)
		Kelch 6	549..599		16/87 (18%)