Protein Alignment Keap1 and kbtbd3

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: XP_002934972.1
• Gene: kbtbd3 / 100490420
• XenbaseID: XB-GENE-6044137
• Length: 607
• Species: Xenopus tropicalis
• Alignment Length: 582
• Identity: 137/582 - (23%)
• Similarity: 232/582 - (39%)
• Gaps: 79/582 - (13%)

  Fly    72 YAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQLQGV 136
            :.::.|.::...|......|..:.||.:|.|.|:.||:|:|.:|:|||...:||.:...|.:..:
 Frog    30 HGQQILSILQNFRDQKAFFDFNIIVKDQLMPCHRCVLAASSDFFRAMFEVNMKERDGGSVTISNL 94

  Fly   137 CPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHFAEQ 201
            ...|::..|.:.|||:..:|:..|..|...::..|||.:..||..||.:.:|..|.:.:...:|.
 Frog    95 SSNAVAAFLDYAYTGKAEITDENVDMLFQMSSFLQVPLLSKACSDFLIKIIDTNNCLQLLSISES 159

  Fly   202 HGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWVKYDED 266
            :|...|...|..|..::|:.:.|..:||:|:...|...:..|.|||.||.....||:.|.|:..|
 Frog   160 YGSTRLFDHALEFSLQHFSLLTQSTDFLELNIGVLEKCLEDDLLNVPEEESALVAVIAWTKHSLD 224

  Fly   267 NRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFKDLTLHKCPGV--KERTP 329
            .|......:|..:|...|:.:.|:..:.:.|.|.|...|...:....|  .:....|:  ..|..
 Frog   225 KRERFFPRLLRTIRLHQLSQSTLQNVLISEDQLLKSTDCLSTINSAIK--RVEAAGGLFPDARLS 287

  Fly   330 NTTRMIFV-----AGGFFRHSLDILEAYNVDDMTWTTLANLR---IPRSGLGA----AFLKG--K 380
            .|.:.|||     .||     ......||:....|..|.:::   :|.|.|.:    .|:.|  |
 Frog   288 TTEKYIFVHKTAEDGG-----TQCTFCYNLKTDKWLELPHIQLTDLPGSSLSSYGEKIFITGGCK 347

  Fly   381 FYAVGGRNNNIGSSYDSDWVDRYSAVTETWRPC---------APMSVPR-HRVGVAVMDELMYAV 435
            .:...|...:|...|       :.|..:||..|         ..|..|| ....|..:::|....
 Frog   348 GHCCRGVRLHIAEPY-------HDATDQTWCYCPASNNSSLVPAMKKPRTMHTSVMALNQLFVIG 405

  Fly   436 GGSAGMEYHNT---VEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIG-------GFDGNER 490
            |.:.|..|..:   ||.|:|....|..|.|:..............::|.:|       .|:
 Frog   406 GKTKGAHYIKSLLDVESYNPLAKEWKSVSPLPRGIYYPEASACKNVIYVLGSEVEITDAFN---- 466

  Fly   491 LASVEC---YHPENNEWSFLPPLQTGRSGAGVAA-------INQYIYVVGGFDGTRQLATVERYD 545
             .|::|   |:.|.|:|..|    ....|....|       :|..:|:.       .|:|.:.|.
 Frog   467 -PSLDCFFKYNAETNQWCEL----VAEFGQFFHATLIKAVPVNNTLYIC-------DLSTYKVYS 519

  Fly   546 --TENDTWDMVAPIQIARSALSLTPLDEKLYAIGG-FDGNNFLSIVEVYDPRTNTWTTGTPL 604
              .|...|......:.|........:::|:|.:|| :..:.....|:||....:.|...:|:
 Frog   520 FCPETCVWKGEGSFECAGFNAGAVGIEDKIYILGGDYAPDEITDEVQVYHSNRSEWEEVSPM 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	132/555 (24%)
		KELCH repeat	369..416	CDD:276965	12/61 (20%)
		KELCH repeat	420..463	CDD:276965	12/46 (26%)
		KELCH repeat	467..510	CDD:276965	10/52 (19%)
		KELCH repeat	514..558	CDD:276965	9/52 (17%)
		KELCH repeat	561..606	CDD:276965	9/45 (20%)
kbtbd3	XP_002934972.1	BTB_POZ_KBTBD3_BKLHD3	24..153	CDD:349580	36/122 (30%)
		PHA03098	62..582	CDD:222983	130/550 (24%)
		KELCH repeat	330..385	CDD:276965	12/61 (20%)
		KELCH repeat	389..437	CDD:276965	13/47 (28%)
		KELCH repeat	440..485	CDD:276965	9/49 (18%)
		KELCH repeat	537..582	CDD:276965	9/45 (20%)