Protein Alignment Keap1 and klhl6

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: XP_002933397.2
• Gene: klhl6 / 100486936
• XenbaseID: XB-GENE-983196
• Length: 610
• Species: Xenopus tropicalis
• Alignment Length: 615
• Identity: 171/615 - (27%)
• Similarity: 284/615 - (46%)
• Gaps: 51/615 - (8%)

  Fly    29 EEAEMSNTSESCSIS--CGGRFGS--AHSTLDDHDATDDDMTFCMSNYAKEALKMMYMMRSHGML 89
            |..|.|......|::  |....|.  .:|:.|:....|...|..:.:..:.       :|....|
 Frog     3 ESVEKSTDDFIISLNSECPKELGELIENSSGDNRKFDDTGFTLALQSGLEN-------LRLENSL 60

  Fly    90 TDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQLQGVCPTAMSRILYFMYTGQIR 154
            |||||.|..::||.|:|||:|||.||:|||...|||....::.:|||.|..|..||.:.||.::.
 Frog    61 TDVVLCVGDKVFPCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIQGVEPETMQIILDYTYTSKVV 125

  Fly   155 VTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHFAEQHGCVELQKKANVFIERNF 219
            :|::.|.::|.||::||...::|||.:||...|.|.|.:||...|:.|....|:.:...:|.:||
 Frog   126 ITKLNVQKILEAASLFQFLRMVDACSSFLTEALHPENCVGILRLADAHSLESLKVQVQNYIIQNF 190

  Fly   220 TQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWVKYDEDNRHCKMEHILGAVRCQFL 284
            :||..:|:|.:|....|..:::.|:|.|.||.:|:..|:.||:|.:..|...:..|:..||...|
 Frog   191 SQVLNQEDFFELPFEILFHMLKSDDLYVTEEAQVFETVINWVEYKKSERLELLPKIMECVRLPLL 255

  Fly   285 TPNFLKEQMKNCDVLRKVPACREYLAKIFKDLTLHKCPG---VKERT-PN----TTRMIFVAGGF 341
            .|.:|...::..:::|:.|.    :..:.::..::...|   :.||| |.    .:.:..:.||.
 Frog   256 DPWYLVGNVEANELIRQCPD----VFPLMQEARIYYMAGNEVISERTKPRIHEFQSEVFMIIGGC 316

  Fly   342 FRHSLDILEAYNVDDMTWTTLANLRIPRSG------------LGAAFLKGKFYAVGGRNNNIGSS 394
            .:....:.|...:|.:..:.|...::|.|.            ......|.:.|..||::     :
 Frog   317 TKDEKFVTEVTCLDPLRRSRLEVAKLPVSDHENESENKKWVEFACITFKNEVYISGGKD-----T 376

  Fly   395 YDSDWVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGGSAGMEYHNTVEYYDPDLDRWTL 459
            ....|  :|::....|.....::|.|.|..:|.:...:||:||..|.:...:||.|||..:.||.
 Frog   377 QQEVW--KYNSSINKWIQIEYLNVGRWRHKMAALCGKVYAIGGFDGSQRIYSVEVYDPFHNGWTE 439

  Fly   460 VQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLAS--VECYHPENNEWSFLPPLQTGRSGAGVAAI 522
            |.|:.............:.||.||| ..|.:||:  .:||.||.|:|....|:..........:.
 Frog   440 VAPLLISASSFAAACHQKKLYVIGG-GPNGKLATDKTQCYDPETNKWCLKSPMPVEAKCINAVSF 503

  Fly   523 NQYIYVVGGFDGTRQLATVERYDTENDTWDMVAPIQIARSALSLTPLDEKLYAIGGFD-GNNFLS 586
            |.:||||||     .:..:..|....|||.:|......|::..:.....|::..||.| .|..::
 Frog   504 NDHIYVVGG-----AMKALYSYSPLEDTWCLVTKFTHERASCGIAACCNKIFITGGRDEKNEVIA 563

  Fly   587 IVEVYDPRTNTWTTGTPLKSGRSGHASAVI 616
            .|..::..|...|....|..|.|.|:|..|
 Frog   564 TVLCWNVETEKLTEECVLPRGVSHHSSVTI 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	150/529 (28%)
		KELCH repeat	369..416	CDD:276965	8/58 (14%)
		KELCH repeat	420..463	CDD:276965	16/42 (38%)
		KELCH repeat	467..510	CDD:276965	14/44 (32%)
		KELCH repeat	514..558	CDD:276965	12/43 (28%)
		KELCH repeat	561..606	CDD:276965	10/45 (22%)
klhl6	XP_002933397.2	BTB_POZ_KLHL6	37..165	CDD:349545	51/134 (38%)
		PHA03098	63..554	CDD:222983	144/507 (28%)
		BACK_KLHL6	158..265	CDD:350521	34/106 (32%)
		KELCH repeat	359..396	CDD:276965	7/43 (16%)
		KELCH repeat	400..444	CDD:276965	17/43 (40%)
		KELCH repeat	447..493	CDD:276965	15/46 (33%)
		KELCH repeat	495..531	CDD:276965	11/40 (28%)
		KELCH repeat	537..581	CDD:276965	9/43 (21%)