Protein Alignment Keap1 and kbtbd2

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: XP_002937037.1
• Gene: kbtbd2 / 100380094
• XenbaseID: XB-GENE-1012666
• Length: 622
• Species: Xenopus tropicalis
• Alignment Length: 560
• Identity: 162/560 - (28%)
• Similarity: 238/560 - (42%)
• Gaps: 108/560 - (19%)

  Fly    64 DMTFCMSNYAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEM 128
            |.|...:.||...|:.:.:.....:|||:||.|:...||.||:||:..|.||:|||..||.||:.
 Frog     5 DETQINTEYAVSLLEQLKLFYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQ 69

  Fly   129 SRVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAI 193
            :.|.|:.|...::..|:.:.|||.:.:.|.||.||...|...||.:|:..|..:|.::::..|.:
 Frog    70 THVHLRNVDAASLQIIITYAYTGNLAINESTVEQLYETACFLQVDDVLQLCREYLIKKINAKNCV 134

  Fly   194 GIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVL 258
            .:..||:...|.||::.|...:|..||.|..:|.|:|||:..||.|:..|.|||::|..|..|.:
 Frog   135 RLLSFADLFSCEELKQSAKRMVEHKFTTVYHQEAFMQLSSELLIELVSSDNLNVEKEETVREAAM 199

  Fly   259 KWVKYDEDNRHCKMEHILGAVRCQFLT---------------------------PNFLKEQ--MK 294
            .|:.|:..:|...:..:|..:|...|:                           |.|.|.:  |.
 Frog   200 SWLDYNTVSRSQYLSTVLSHLRIDALSEVIQREWFQGLPPNDKSVVVQGLYKSMPRFFKPRLGMT 264

  Fly   295 NCDVLRKVPACRE---YLA---------KIFK----DLTLHKCPGVKERTPNTTRMIFVAGGFFR 343
            ..:::..:.|..|   |.:         |::|    ...|||...|.  ||:..  |::|||
 Frog   265 KEEMIIIIEAASENPSYCSTVCYSPQAEKVYKLSNPPAELHKVGTVV--TPDND--IYIAGG--- 322

  Fly   344 HSLDILEAYNVDDMTWTTLANLRIPRSGLGAAFLKGKFYAVGGRNNNIGSSYDSDWVDRYSAVTE 408
                       .....||.:|...| |.|.|||            ..:...|   |.|   |...
 Frog   323 -----------QVPVKTTKSNHSKP-SKLQAAF------------RTVNCFY---WFD---AQQN 357

  Fly   409 TWRPCAPMSVPRHRVGVAVMDELMYAVGG-SAGMEYH-NTVEYYDPDLDRWTLVQPMHAKRLGVG 471
            ||.|..||...|.:..:...|..:||:|| :||.|.: .|||.||.:.|.||:|.|:........
 Frog   358 TWIPKTPMLSVRTKPSLVWCDGYIYAIGGDNAGGELNRRTVERYDCERDEWTMVSPLPCAWQWNV 422

  Fly   472 VVVVNRLLYAIGGFDGNERLASVECYHPENNEWSFLPPLQTGRSGAGVAAINQYIYVVGG----- 531
            .|||:..:|.:.       .....||.|....|..:...||.|..|..||....|:.:||
 Frog   423 AVVVHDCIYVMA-------YNMTYCYVPRTGMWVEMAMRQTSRCFASAAAFEDKIFYLGGVHIGN 480

  Fly   532 ----------FDGTRQLATVERYDTENDTWDMVAPIQIAR 561
                      .||:.  .|||.||...:.|.|.|.|...|
 Frog   481 SSGIRLPSNTVDGSS--VTVEVYDVNKNEWHMGASIPAKR 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	154/532 (29%)
		KELCH repeat	369..416	CDD:276965	12/46 (26%)
		KELCH repeat	420..463	CDD:276965	18/44 (41%)
		KELCH repeat	467..510	CDD:276965	8/42 (19%)
		KELCH repeat	514..558	CDD:276965	17/58 (29%)
		KELCH repeat	561..606	CDD:276965	1/1 (100%)
kbtbd2	XP_002937037.1	BTB_POZ_KBTBD2_BKLHD1	5..137	CDD:349579	46/131 (35%)
		PHA03098	23..510	CDD:222983	153/532 (29%)
		BACK_KBTBD2	128..223	CDD:350554	31/94 (33%)
		KELCH repeat	309..365	CDD:276965	23/92 (25%)
		KELCH repeat	369..415	CDD:276965	19/45 (42%)
		KELCH repeat	418..452	CDD:276965	8/40 (20%)
		KELCH repeat	458..515	CDD:276965	17/58 (29%)