Protein Alignment Keap1 and klhl28

DIOPT Version :10

• Sequence 1: NP_732202.2
• Gene: Keap1 / 42062
• FlyBaseID: FBgn0038475
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: XP_073784082.1
• Gene: klhl28 / 100333404
• -ID: -
• Length: 571
• Species: Danio rerio
• Alignment Length: 569
• Identity: 199/569 - (34%)
• Similarity: 298/569 - (52%)
• Gaps: 34/569 - (5%)

  Fly    72 YAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQLQGV 136
            ::::.|:.:.::|....|.|:||.|......||||||::.||||||||||.|.|.|.|.|:.|.:
Zfish    17 HSEQLLQGLQLLRQDHELCDIVLRVGDAKIHAHKVVLASISPYFKAMFTGNLSEKETSEVEFQCI 81

  Fly   137 CPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHFAEQ 201
            ...|:..|:.:.|||.:.:::.||..|||||.:.||..|:..||:|||.|||..|.|||:.|||.
Zfish    82 DEAALKAIVEYAYTGTVFISQETVESLLPAANLLQVKLVLKECCSFLESQLDAGNCIGISRFAET 146

  Fly   202 HGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWVKYDED 266
            :||.:|...|:.||.::|.:|||.|||.:|:..:|..::..|.|||..|..|:.|:..|:|||..
Zfish   147 YGCHDLCLAASKFICQHFEEVCQTEEFFELTRAELDDIVSNDCLNVLTEESVFYALESWIKYDVS 211

  Fly   267 NRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFKDLTLHKCP--GVKERTP 329
            .|...:..:|..||...|:..||....:...::|...||:..|.:..|   .|..|  .:..:|.
Zfish   212 ERQQHLAQLLHCVRLPLLSVKFLTRLYEANHLIRDDHACKHLLNEALK---YHFMPEHRLSYQTV 273

  Fly   330 NTTR-------MIFVAG--GFFRHSLDILEAYNVDDMTWTTLANLRIPRSGLGAAFLKGKFYAVG 385
            .:||       ::.|.|  |.|. :|:.:|.|.....:|..||.|.:||...|.|.|:.:.|.:|
Zfish   274 LSTRPRCAPKVLLAVGGKAGLFA-TLESMEMYFPQTDSWLGLAPLPVPRYEFGVAVLEQQVYVLG 337

  Fly   386 GRNNNI--GSSY--DSDWVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGGSAGMEYHNT 446
            |...::  |.||  ....|:|:...|.||.....|:..|..:||.|:...:||:||..|..|..:
Zfish   338 GIATHMRQGISYRRHESSVERWHPDTNTWSSERRMAESRSTLGVVVLAGELYALGGYDGQYYLQS 402

  Fly   447 VEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYHPENNEWSFLPPLQ 511
            ||.|.|.|..|..|.||...|......|::.::|||||: |...:.|||.|.|..:.|..:.|:.
Zfish   403 VEKYLPKLKEWQPVAPMTKSRSCFATAVLDGMIYAIGGY-GPAHMNSVERYDPSKDSWDMVAPMA 466

  Fly   512 TGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWDMVAPIQIARSALSLTPLDEKLYAI 576
            ..|...||..:..:|:||||.:|...|:::||||...:.|....|:...|:.:....:|..||.:
Zfish   467 DKRINFGVGVMLGFIFVVGGHNGVSHLSSIERYDPYQNQWTACRPMNEPRTGVGSAVVDNLLYVV 531

  Fly   577 GGFDGNNFLSIVEVYDPRTNTWTTGTPLKSGRSGHASAVIYQPACSTTF 625
            ||..|:::|:.|:.|||.|:.|.           .||.::|   |...|
Zfish   532 GGHSGSSYLNAVQRYDPLTDGWI-----------DASGMMY---CRCNF 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	PHA03098	92..599	CDD:222983	189/521 (36%)
		KELCH repeat	369..416	CDD:276965	15/50 (30%)
		KELCH repeat	420..463	CDD:276965	17/42 (40%)
		KELCH repeat	467..510	CDD:276965	14/42 (33%)
		KELCH repeat	514..558	CDD:276965	16/43 (37%)
		KELCH repeat	561..606	CDD:276965	14/44 (32%)
klhl28	XP_073784082.1	None