DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Keap1 and ipp

DIOPT Version :9

Sequence 1:	NP_732202.2	Gene:	Keap1 / 42062	FlyBaseID:	FBgn0038475	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	XP_012816160.1	Gene:	ipp / 100327249	XenbaseID:	XB-GENE-491275	Length:	584	Species:	Xenopus tropicalis

Alignment Length:	575	Identity:	185/575 - (32%)
Similarity:	296/575 - (51%)	Gaps:	48/575 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 TDDDMTFC---MSNYAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGG 122
            |:...:.|   :..:|:..|..|..||......||.:::....|..||:||:|:||||.|:..||
Frog     5 TETKASTCLRILDKHAQLILAQMNRMRHQLEFCDVQIQIGDVKFGVHKLVLAASSPYFAALLAGG 69

  Fly   123 LKESEMSRVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLERQL 187
            :|||....||:||:.|.:...||.|:|||.::::...|..|:.||.|.|:.:|::.||.||:...
Frog    70 MKESLTEVVQIQGLNPNSFQLILDFIYTGSVKISTDNVEDLMTAADMLQLSHVVELCCDFLKEHT 134

  Fly   188 DPTNAIGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQEERE 252
            :|.|.||...|||...|..|.:....:|..:||:|...:||..|:..||:.:::.:||::::|.:
Frog   135 EPANCIGFFQFAEHLSCQPLLEYTESYIHTHFTEVQIGDEFPTLTKDQLVQILQSEELSIEDEYQ 199

  Fly   253 VYNAVLKWVKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKN-CDVLRKV---PACREY--LAK 311
            |::|.:.|::.|...|...:..:|..||...|.|..|.:.::: .|...:|   ...|||  |:.
Frog   200 VFSAAMIWIQKDIVTRKRHVIEVLEPVRFSLLPPKRLHKAIEDVADFSLRVALQTLLREYCELSH 264

  Fly   312 IFKDLTLHKC---------PGVKERTPNTTRMIFVAGGFFR---------HSLDILEAYNVDDMT 358
            ..||..|  |         |..|.|     :.::..||:.|         .:|..:|.::.....
Frog   265 SPKDKKL--CNFLQTSRVRPRRKAR-----KFLYAIGGYTRLLGGRWSDSRALSCVERFDTFSQY 322

  Fly   359 WTTLANLRIPRSGLGAAFLKGKFYAVGGRNNNIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRV 423
            |:|:::|...|||:..|.|:|:.|.:||..:    |...|.|:.|..|::.|...:.|:.||..:
Frog   323 WSTVSSLHQARSGMSVAVLEGRIYVIGGEKD----SMIFDCVECYDPVSKQWAAVSSMNQPRCGL 383

  Fly   424 GVAVMDELMYAVGGSAGMEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGF--D 486
            ||......:||:||..|.|..|::|.:.|:.:.|.:|..|...|..........::|.:||.  :
Frog   384 GVCACHGAIYALGGWVGSEIGNSIERFSPEENAWQVVGSMAVPRYNFACCERQGMIYVVGGISHE 448

  Fly   487 GNERLASVECYHPENNEWSFLPPLQTGRSGAGVAAINQYIYVVGGFDGTRQ-LATVERYDTENDT 550
            |.| |.|.|.|.|....|..|||:.|.|:..|||.:|..:|.|||.|.::. |.|||::..|.:.
Frog   449 GTE-LRSAEVYDPITRRWMSLPPMGTRRAYLGVACLNDCLYAVGGGDDSQDALNTVEKFSFEEEQ 512

  Fly   551 WDMVAPIQIARSALSLTPLDEKLYAIGGFD-GNNFLS-----IVEVYDPRTNTWT 599
            |..|||::|.|..:|:..::..|||.||.. ..||.:     .||||:|.|::||
Frog   513 WVEVAPMKIPRCGVSVVSVNGLLYAAGGRSIKQNFTAPVTTDTVEVYNPHTDSWT 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	BTB	80..183	CDD:279045	41/102 (40%)
		PHA03098	92..599	CDD:222983	175/539 (32%)
		BACK	192..294	CDD:285009	30/101 (30%)
		Kelch	335..379	CDD:128874	13/52 (25%)
		KELCH repeat	369..416	CDD:276965	15/46 (33%)
		Kelch	382..430	CDD:128874	14/47 (30%)
		KELCH repeat	420..463	CDD:276965	14/42 (33%)
		Kelch	433..476	CDD:128874	13/42 (31%)
		KELCH repeat	467..510	CDD:276965	14/44 (32%)
		Kelch	478..523	CDD:128874	19/46 (41%)
		KELCH repeat	514..558	CDD:276965	19/44 (43%)
		Kelch_1	514..556	CDD:279660	17/42 (40%)
		KELCH repeat	561..606	CDD:276965	17/45 (38%)
		Kelch	572..616	CDD:128874	15/34 (44%)
ipp	XP_012816160.1	BTB_POZ_KLHL27_IPP	17..141	CDD:349565	47/123 (38%)
		PHA03098	30..567	CDD:222983	178/548 (32%)
		KELCH repeat	333..376	CDD:276965	15/46 (33%)
		KELCH repeat	380..424	CDD:276965	14/43 (33%)
		KELCH repeat	427..473	CDD:276965	15/46 (33%)
		KELCH repeat	475..520	CDD:276965	19/44 (43%)
		KELCH repeat	523..574	CDD:276965	17/45 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010