DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Keap1 and klhl18

DIOPT Version :9

Sequence 1:	NP_732202.2	Gene:	Keap1 / 42062	FlyBaseID:	FBgn0038475	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_001123404.1	Gene:	klhl18 / 100170176	XenbaseID:	XB-GENE-5759414	Length:	578	Species:	Xenopus tropicalis

Alignment Length:	605	Identity:	194/605 - (32%)
Similarity:	301/605 - (49%)	Gaps:	88/605 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 LDDHDATDDDMTFCMSNYAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMF 119
            :|:.:..:|.:...:.:.......:|..:|..|.|.||.|.|.:..|.||::||:|:.|||.|||
Frog     2 VDELEELEDLVHVTVGDLPSRGYGVMEEIRRQGKLCDVTLRVGEHKFSAHRIVLAASIPYFHAMF 66

  Fly   120 TGGLKESEMSRVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVPNVIDACCAFLE 184
            |..:.|.:...:.:||:..:|:..::.|.|.|.:.:.:..|..||..|:..|:.|:.||||.||:
Frog    67 TNDMVECKQDEIVMQGMDASALEALINFAYNGHLAIDQQNVQSLLMGASFLQLQNIKDACCTFLK 131

  Fly   185 RQLDPTNAIGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIALIRRDELNVQE 249
            .:|.|.|.:|:..|||...|..|...:|.||..:|.:|...||||.|:..:::.|:.||||||:.
Frog   132 ERLHPKNCLGVRQFAETMMCAVLHDASNRFIHEHFVEVSMSEEFLALAFEEVLELVSRDELNVKA 196

  Fly   250 EREVYNAVLKWVKYDEDNRHCKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFK 314
            |.:|:.|.|.||:||.:.|...:..:|..:|.....|.||.::::..|::|....||: |....|
Frog   197 EEQVFEAALAWVRYDREKREVFLPELLSKIRLPLCRPQFLTDRVQQDDLVRCCHKCRD-LVDEAK 260

  Fly   315 DLTLHKCPGVKERTPNTTRMIFVAGGFFRHSLDILEAYNVDDMTWTTLANLRIPRSGLGAAFLKG 379
            |  .|..|   ||.|:                  |.|:.......|::|               |
Frog   261 D--YHLMP---ERRPH------------------LLAFKTRPRCCTSIA---------------G 287

  Fly   380 KFYAVGGRNN--NIGSSYDSDWVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYAVGGSAGME 442
            ..|||||.|:  |..:....:.|:.:..:...|..|.||:..|.||||||::.|:||:||..|..
Frog   288 LIYAVGGLNSAANFYAGDSLNVVEVFDPIANRWEKCQPMTTARSRVGVAVVNGLLYAIGGYDGQS 352

  Fly   443 YHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFDGNERLASVECYHPENNEWSFL 507
            ..:|||.|:||.|.||.|..|::||..:|.||::..:|..||:|||..|.|||.|.||.::|:.:
Frog   353 RLSTVEVYNPDTDTWTKVGSMNSKRSAMGTVVLDGQIYVCGGYDGNCSLNSVEAYSPETDKWTVV 417

  Fly   508 PPLQTGRSGAGV-----------------------------------------------AAINQY 525
            .|:.:.||.|||                                               |::...
Frog   418 TPMSSNRSAAGVTVFEGRIYVSGGHDGLQIFNTVEYYNHHTATWHPVASMMNKRCRHGAASLGSK 482

  Fly   526 IYVVGGFDGTRQLATVERYDTENDTWDMVAPIQIARSALSLTPLDEKLYAIGGFDGNNFLSIVEV 590
            :|:.||::|:..|:..|.|::..|.|.::.|:...||.:||.....:|||:||:||.:.|:.||:
Frog   483 MYICGGYEGSAFLSVAEVYNSMADQWYLITPMNTRRSRVSLVANCGRLYAVGGYDGQSNLNSVEM 547

  Fly   591 YDPRTNTWTTGTPLKSGRSG 610
            |||.||.||...|:.....|
Frog   548 YDPETNRWTFMAPMVCHEGG 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	BTB	80..183	CDD:279045	38/102 (37%)
		PHA03098	92..599	CDD:222983	183/555 (33%)
		BACK	192..294	CDD:285009	37/101 (37%)
		Kelch	335..379	CDD:128874	4/43 (9%)
		KELCH repeat	369..416	CDD:276965	11/48 (23%)
		Kelch	382..430	CDD:128874	19/49 (39%)
		KELCH repeat	420..463	CDD:276965	23/42 (55%)
		Kelch	433..476	CDD:128874	21/42 (50%)
		KELCH repeat	467..510	CDD:276965	18/42 (43%)
		Kelch	478..523	CDD:128874	21/91 (23%)
		KELCH repeat	514..558	CDD:276965	16/90 (18%)
		Kelch_1	514..556	CDD:279660	15/88 (17%)
		KELCH repeat	561..606	CDD:276965	22/44 (50%)
		Kelch	572..616	CDD:128874	19/39 (49%)
klhl18	NP_001123404.1	BTB_POZ_KLHL18	18..133	CDD:349556	40/114 (35%)
		PHA03098	33..556	CDD:222983	186/561 (33%)
		BACK_KLHL18	134..240	CDD:350532	40/105 (38%)
		KELCH repeat	281..326	CDD:276965	13/59 (22%)
		KELCH repeat	330..373	CDD:276965	23/42 (55%)
		KELCH repeat	377..421	CDD:276965	19/43 (44%)
		KELCH repeat	424..468	CDD:276965	5/43 (12%)
		KELCH repeat	471..515	CDD:276965	11/43 (26%)
		KELCH repeat	518..561	CDD:276965	21/42 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010