DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Keap1 and ivns1abp

DIOPT Version :9

Sequence 1:	NP_732202.2	Gene:	Keap1 / 42062	FlyBaseID:	FBgn0038475	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	XP_012816907.1	Gene:	ivns1abp / 100145550	XenbaseID:	XB-GENE-949332	Length:	665	Species:	Xenopus tropicalis

Alignment Length:	678	Identity:	178/678 - (26%)
Similarity:	278/678 - (41%)	Gaps:	150/678 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 CGGRFGSAHSTLDDHDATDDDMTFCMSNYAKEALKMMYMMRSHGMLTDVVLEVKKELFPAHKVVL 108
            ||...|:....:.:.....:|..|..|:.||     :..:|..|...||.|:|......||:.||
Frog    18 CGVAQGTHRKMVPNGSLNFEDEQFIESSVAK-----LNALRKSGQFCDVKLQVCGHEMLAHRAVL 77

  Fly   109 SAASPYFKAMFTGGLKESEMSRVQLQGVCPTAMSRILYFMYTGQIRVTEVTVCQLLPAATMFQVP 173
            :..||:...:|....:...:|.|:...:.|.|:..:|.:.||.|::.....|..:..||...::.
Frog    78 ACCSPFLFEIFNSDGESHGISLVRFDDLNPDAVEVLLNYAYTSQLKAETDLVKDVYSAAKKLKID 142

  Fly   174 NVIDACCAFLERQLDPTNAIGIAHFAEQHGCVELQKKANVFIERNFTQVCQEEEFLQLSAYQLIA 238
            .|...|..:|..::|..:.|...:|....|...|..|.:.:|:.:..::.::|:||:|....| .
Frog   143 RVKQVCGDYLLSKIDVQSCISYRNFVNAMGDWRLLSKIDNYIQEHLLEISEQEDFLKLPRLNL-E 206

  Fly   239 LIRRDELNVQEEREVYNAVLKWVK---------------------YDEDNRHCKM----EHI--- 275
            ::..:.:::....::|..|:.||:                     |..|::....    ||.
Frog   207 IMLEENVSLPSNGKLYTKVINWVQRSIWENGENLDALLEEVQTLYYSADHKLLDASLLGEHTDAY 271

  Fly   276 -------------------LGAVRCQFLTPNFLKEQMKNCDVLRKVPA----------CREYLAK 311
                               |.:.....|:|..|.:..|:   ..|:.|          |...|..
Frog   272 EDNIQLIQKKSPRENNHKNLSSSSSGSLSPTALTQSPKH---EWKIIASEKKTNNTYLCLAVLNS 333

  Fly   312 IFKDLTLH--KCP-GVKERTPNTTRMIFVAGGFFRHSLDILEAYNVDDMTWTTLANLRIPRSGLG 373
            :...:.||  ..| .....||..|:.:         ||:|    ..||.....::.:...|||||
Frog   334 MLCVIFLHGRNSPVNSPSSTPRLTKSL---------SLEI----QPDDSLERVMSPMHYARSGLG 385

  Fly   374 AAFLKGKFYAVGGRNNNIGSSYDSD----WVDRYSAVTETWRPCAPMSVPRHRVGVAVMDELMYA 434
            .|.|.||..|.||        |:.:    .|:.|...|:.|...|||..||.|..:||:.:.:|.
Frog   386 TAELNGKLIAAGG--------YNREECLRTVECYDPETDIWTFIAPMKTPRARFQMAVLMDHLYV 442

  Fly   435 VGGSAGMEYH----NTVEYYDPDLDRWTLVQPMHAKRLGVGVVVVNRLLYAIGGFD--------- 486
            ||||.|   |    :..|.|||..:.|..|..:.:.|...||..:|..||.:||.|
Frog   443 VGGSNG---HSDDLSCGEKYDPKSNVWISVPELRSNRCNAGVCALNGKLYVVGGSDPYGQKGLKN 504

  Fly   487 -----------------------------GNER-----------LASVECYHPENNEWSFLPPLQ 511
                                         ||:.           |.|||||:|||:.|:.:.|:.
Frog   505 CDVFDPITRMWTCCAQLNIRRHQSAVCELGNKMYIIGGAESWNCLNSVECYNPENDTWTLVAPMN 569

  Fly   512 TGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTENDTWDMVAPIQIARSALSLTPLDEKLYAI 576
            ..|.|||||.....::||||||||..|:.||.||.|.:.|.|:..:..|||...:..:.:::||.
Frog   570 VARRGAGVAVYEGKLFVVGGFDGTHALSCVESYDPERNEWKMMGSMTSARSNAGMVAVGDQIYAA 634

  Fly   577 GGFDGNNFLSIVEVYDPRTNTWTTGTPL 604
            ||||||.||:.:|||:|:|..|:..|.|
Frog   635 GGFDGNEFLNTIEVYNPQTEEWSPFTHL 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	BTB	80..183	CDD:279045	26/102 (25%)
		PHA03098	92..599	CDD:222983	164/623 (26%)
		BACK	192..294	CDD:285009	23/148 (16%)
		Kelch	335..379	CDD:128874	12/43 (28%)
		KELCH repeat	369..416	CDD:276965	18/50 (36%)
		Kelch	382..430	CDD:128874	16/51 (31%)
		KELCH repeat	420..463	CDD:276965	17/46 (37%)
		Kelch	433..476	CDD:128874	16/46 (35%)
		KELCH repeat	467..510	CDD:276965	21/91 (23%)
		Kelch	478..523	CDD:128874	24/93 (26%)
		KELCH repeat	514..558	CDD:276965	22/43 (51%)
		Kelch_1	514..556	CDD:279660	22/41 (54%)
		KELCH repeat	561..606	CDD:276965	20/44 (45%)
		Kelch	572..616	CDD:128874	18/33 (55%)
ivns1abp	XP_012816907.1	BTB_POZ_NS1BP	41..164	CDD:349615	33/127 (26%)
		PHA03098	50..665	CDD:222983	170/641 (27%)
		KELCH repeat	381..424	CDD:276965	18/50 (36%)
		KELCH repeat	428..473	CDD:276965	17/47 (36%)
		KELCH repeat	476..521	CDD:276965	9/44 (20%)
		KELCH repeat	525..568	CDD:276965	12/42 (29%)
		KELCH repeat	572..616	CDD:276965	22/43 (51%)
		KELCH repeat	619..662	CDD:276965	19/42 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010