DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Keap1 and klhl4

DIOPT Version :9

Sequence 1:	NP_732202.2	Gene:	Keap1 / 42062	FlyBaseID:	FBgn0038475	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_001096427.1	Gene:	klhl4 / 100125035	XenbaseID:	XB-GENE-988002	Length:	719	Species:	Xenopus tropicalis

Alignment Length:	605	Identity:	214/605 - (35%)
Similarity:	330/605 - (54%)	Gaps:	28/605 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 PEEAEMSNTSESCSISCGGRFGSAHSTLDDHDATDDDMTFCMSNYAKEALKMMYMMRSHGMLTDV 92
            |||...:.| :...::|        |:.:..:|:..|..|...|:|::..:.|........|.||
Frog   130 PEEHPEAAT-DRLHVTC--------SSPNRMNASGSDEYFQSLNHAEQTFRKMENYLQQKQLCDV 185

  Fly    93 VLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQLQGVCPTAMSRILYFMYTGQIRVTE 157
            :|.......|||::||||.|.||.||||..::|::...::::||.|.|:..::::.|||.:.:.|
Frog   186 LLIAGNLKIPAHRLVLSAVSDYFAAMFTNDVREAKEEEIKIEGVDPDALKALVHYAYTGVLELKE 250

  Fly   158 VTVCQLLPAATMFQVPNVIDACCAFLERQLDPTNAIGIAHFAEQHGCVELQKKANVFIERNFTQV 222
            .|:..||.||.:.|:..|||.||.||.:||.|:|.:||..|.:..|||||.:.|:.:...:|.:|
Frog   251 DTIESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCLGIRSFGDAQGCVELLRVAHSYTMEHFIEV 315

  Fly   223 CQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWVKYDEDNRHCKMEHILGAVRCQFLTPN 287
            .:.:|||.|.|.::..|:..|::||.:|..::.|:::|||:|...|...:..:|..:|...|.|.
Frog   316 IRNQEFLLLPASEIAKLLSSDDINVPDEETIFQALMQWVKHDIQCRQRDLGMLLSYIRLPLLPPQ 380

  Fly   288 FLKEQMKNCDVLRKVPACREYLAKIFK------DLTLHKCPGVKERTPNTTRMIFVAGGF-FRHS 345
            .|.: ::|..:......|:::|.:..|      ..::.:.|..|.| .:|...::..||. ....
Frog   381 LLAD-LENSPMFANDLECQKFLMEAMKYHLLPERRSMMQSPRTKPR-KSTVGALYAVGGMDATKG 443

  Fly   346 LDILEAYNVDDMTWTTLANLRIPRSGLGAAFLKGKFYAVGGRNNNIGSSYDSDWVDRYSAVTETW 410
            ...:|.|::...:|..::.:...|...|.|.:..|.|.||||:    ....|:.|:.::.||:.|
Frog   444 ATTIEKYDLRTNSWIQISTMNGRRLQFGVAVIDNKLYVVGGRD----GLKTSNTVECFNPVTKVW 504

  Fly   411 RPCAPMSVPRHRVGVAVMDELMYAVGGSAGMEYHNTVEYYDPDLDRWTLVQPMHAKRLGVGVVVV 475
            ....|||..||.:||||::..||||||..|..|.||||.:||...:|..|..|...|..|||..:
Frog   505 SIMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNYVASMSTPRSTVGVAAL 569

  Fly   476 NRLLYAIGGFDGNERLASVECYHPENNEWSFLPPLQTGRSGAGVAAINQYIYVVGGFDG------ 534
            |..|||:||.||:..|.|:||:.|..|:||...|:...|.|.|||..|.::|.|||.|.
Frog   570 NSKLYAVGGRDGSSCLKSMECFDPHTNKWSMCSPMSKRRGGVGVATYNGFLYAVGGHDAPASNHC 634

  Fly   535 TRQLATVERYDTENDTWDMVAPIQIARSALSLTPLDEKLYAIGGFDGNNFLSIVEVYDPRTNTWT 599
            :|....|||||.:.|.|.||||:.|.|.|:.::||.::|||:||:||.::|:|||.||.:||.||
Frog   635 SRLSDCVERYDPKTDNWTMVAPLSIPRDAVGVSPLGDRLYAVGGYDGQSYLNIVESYDAQTNEWT 699

  Fly   600 TGTPLKSGRSGHASAVIYQP 619
            ....|..||:|....||..|
Frog   700 QDVSLNIGRAGACLEVIKLP 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Keap1	NP_732202.2	BTB	80..183	CDD:279045	39/102 (38%)
		PHA03098	92..599	CDD:222983	191/519 (37%)
		BACK	192..294	CDD:285009	32/101 (32%)
		Kelch	335..379	CDD:128874	8/44 (18%)
		KELCH repeat	369..416	CDD:276965	14/46 (30%)
		Kelch	382..430	CDD:128874	19/47 (40%)
		KELCH repeat	420..463	CDD:276965	22/42 (52%)
		Kelch	433..476	CDD:128874	20/42 (48%)
		KELCH repeat	467..510	CDD:276965	20/42 (48%)
		Kelch	478..523	CDD:128874	21/44 (48%)
		KELCH repeat	514..558	CDD:276965	23/49 (47%)
		Kelch_1	514..556	CDD:279660	21/47 (45%)
		KELCH repeat	561..606	CDD:276965	22/44 (50%)
		Kelch	572..616	CDD:128874	21/43 (49%)
klhl4	NP_001096427.1	BTB_POZ_KLHL4	164..289	CDD:349645	48/124 (39%)
		PHA03098	177..701	CDD:222983	195/529 (37%)
		KELCH repeat	467..510	CDD:276965	14/46 (30%)
		KELCH repeat	514..558	CDD:276965	22/43 (51%)
		KELCH repeat	561..604	CDD:276965	20/42 (48%)
		KELCH repeat	608..657	CDD:276965	22/48 (46%)
		KELCH repeat	661..699	CDD:276965	19/37 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920