DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ns1 and NOA1

DIOPT Version :9

Sequence 1:	NP_732199.2	Gene:	Ns1 / 42060	FlyBaseID:	FBgn0038473	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_115689.1	Gene:	NOA1 / 84273	HGNCID:	28473	Length:	698	Species:	Homo sapiens

Alignment Length:	452	Identity:	99/452 - (21%)
Similarity:	150/452 - (33%)	Gaps:	166/452 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 PNICPFKDDILKEVEEAKQRQEAERLARREAFKAEREQNKFKTLESMVEDADMRSTVHGIMHEND 118
            |...|.::..|:|:::.::.:|.:|..|||    ||.|...:.          ||..|.::...|
Human    81 PEPQPTREKQLQELQQQQEEEERQRQQRRE----ERRQQNLRA----------RSREHPVVGHPD 131

  Fly   119 ------------------AQDQD-------EKKYKNA---------------------------V 131
                              .||..       ||..:.|                           |
Human   132 PALPPSGVNCSGCGAELHCQDAGVPGYLPREKFLRTAEADGGLARTVCQRCWLLSHHRRALRLQV 196

  Fly   132 TKEQSLKQYFKEFRKVIENADVVLEVVDARDPLGTRCNEVERAVRGAPGNKRLVLVLNKADLVP- 195
            ::||.|:......|:  ....:||.:||..|.......::...|    |.|:|:::.||.||:|
Human   197 SREQYLELVSAALRR--PGPSLVLYMVDLLDLPDALLPDLPALV----GPKQLIVLGNKVDLLPQ 255

  Fly   196 ---------RENLNNWIKYFR--------RSGPVTAFKASTQDQAN----RLGRRKLREMKTEKA 239
                     ||.|  |....|        ..||....|...||..|    ...|..:|:::...|
Human   256 DAPGYRQRLRERL--WEDCARAGLLLAPGHQGPQRPVKDEPQDGENPNPPNWSRTVVRDVRLISA 318

  Fly   240 MQGSVCIGAELLMSMLGNYCRNKGIKTSIRVGVVGIPNVGKSSIINSLTRGRSC----------- 293
            ..|   .|.|.|:|.|....|.:|     .|.:||..|.|||::.|:|.....|
Human   319 KTG---YGVEELISALQRSWRYRG-----DVYLVGATNAGKSTLFNTLLESDYCTAKGSEAIDRA 375

  Fly   294 MVGSTPGVT-----------------KSMQEVELDSKIKLIDCPGIVFTSGGENSHAVLKN---- 337
            .:...||.|                 |..|.::.||.....|     .:...:|...|||.
Human   376 TISPWPGTTLNLLKFPICNPTPYRMFKRHQRLKKDSTQAEED-----LSEQEQNQLNVLKKHGYV 435

  Fly   338 AQRVG-------DVKD--PFTI-AESV-----------LKRASKEYFCTMYDITN----YDT 374
            ..|||       :.||  ||.. |:|:           ..:::|:...|..|:.:    |||
Human   436 VGRVGRTFLYSEEQKDNIPFEFDADSLAFDMENDPVMGTHKSTKQVELTAQDVKDAHWFYDT 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ns1	NP_732199.2	GN3L_Grn1	17..88	CDD:285863	9/33 (27%)
		SurA_N_3	59..>150	CDD:304439	24/142 (17%)
		RbgA	121..443	CDD:224083	82/367 (22%)
		Nucleostemin_like	152..322	CDD:206753	54/219 (25%)
		Ras_like_GTPase	271..>400	CDD:206648	36/161 (22%)
NOA1	NP_115689.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..66
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	80..134		16/66 (24%)
		RbgA	139..660	CDD:331156	83/380 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	279..306		6/26 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900