DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ns1 and AtNug2

DIOPT Version :9

Sequence 1:	NP_732199.2	Gene:	Ns1 / 42060	FlyBaseID:	FBgn0038473	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_175706.1	Gene:	AtNug2 / 841731	AraportID:	AT1G52980	Length:	576	Species:	Arabidopsis thaliana

Alignment Length:	660	Identity:	168/660 - (25%)
Similarity:	258/660 - (39%)	Gaps:	180/660 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LKTKKSKRLTGRLKHKIEKKVRDHNKK--ERRAA---------KKNPKKG------SKKQKLIQI 53
            :|.:|...::|:.||.::....|..||  |.|:.         |..||:.      |.:.:..::
plant     2 VKKEKKANVSGKPKHSLDANRADGKKKTTETRSKSTVNRLKMYKTRPKRNAGGKILSNEYQSKEL 66

  Fly    54 PN--ICP------------------FKDD-----------ILKE------VEEAKQRQEAERLAR 81
            ||  |.|                  |:::           ||||      :....::|....|..
plant    67 PNSRIAPDRRWFGNTRVVNQKELEYFREELQTKMSSNYNVILKERKLPMSLLTDNKKQSRVHLLD 131

  Fly    82 REAF------KAEREQNKF--KTLESMVEDADMRSTVHGIMHENDAQDQDEKKYKNAV------- 131
            .|.|      |.:|::.|.  ...|::|:.|              |:.||..:.||..
plant   132 MEPFQDAFGRKTKRKRPKLVASDYEALVKKA--------------AESQDAFEEKNGAGPSGEGG 182

  Fly   132 ---------------TKEQSLKQYFKEFRKVIENADVVLEVVDARDPLGTRCNEVERAVRGAPGN 181
                           .|.|| |:.:.|..|||:::||:::|:|||||.||||:.:|:.::....:
plant   183 EEEDGFRDLVRHTMFEKGQS-KRIWGELYKVIDSSDVIVQVIDARDPQGTRCHHLEKTLKEHHKH 246

  Fly   182 KRLVLVLNKADLVPRENLNNWIKYFRRSGPVTAFKASTQDQANRLGRRKLREMKTEKAMQGSVCI 246
            |.::|:|||.||||......|::...:..|..||.||....                       .
plant   247 KHMILLLNKCDLVPAWATKGWLRVLSKEYPTLAFHASVNKS-----------------------F 288

  Fly   247 GAELLMSMLGNYCRNKGIKTSIRVGVVGIPNVGKSSIINSLTRGRSCMVGSTPGVTKSMQEVELD 311
            |...|:|:|..:.|.|..|.:|.||.||.|||||||:||:|.....|.|...||.||..|.:.|.
plant   289 GKGSLLSVLRQFARLKSDKQAISVGFVGYPNVGKSSVINTLRTKNVCKVAPIPGETKVWQYITLT 353

  Fly   312 SKIKLIDCPGIVFTSGGENSHAVLKNAQRVGDVKDPFTIAESVLKRASKEYFCTMYDITNYDTFE 376
            .:|.||||||:|:.|....:..|||...||.:::|.......||:|..||:....|.|.:::...
plant   354 KRIFLIDCPGVVYQSRDTETDIVLKGVVRVTNLEDASEHIGEVLRRVKKEHLQRAYKIKDWEDDH 418

  Fly   377 EFFAKKAARMGKFLKKGVPDVVAAARSVLNDWNTGKIKYCTQPPEVQEGQSVHISASIVHSEARE 441
            :|..:.....||.||.|.||::..|:.:|:||..|:|.:...||::....|.  |..||....:|
plant   419 DFLLQLCKSSGKLLKGGEPDLMTGAKMILHDWQRGRIPFFVPPPKLDNVASE--SEVIVPGIDKE 481

  Fly   442 FDVENFESMETEILEHCAVKTDDIMEITSTGPLEIRQPREEAEPADKITASLVIDEKEKPAKGRK 506
            ...:|                                  .:|..|.|..|.::..:::|....::
plant   482 AIADN----------------------------------SQAAAALKAIAGIMSTQQQKDVPVQR 512

  Fly   507 RKLDEEKEKVDPSLLLEENQSLNKGIKQMQKLKKKQNVRNEKKISKITDVLDSFSLGPSSSKAEK 571
            ...||:..|.|                      ||.....|......||..:.............
plant   513 DFYDEKDLKDD----------------------KKAKESTETDAENGTDAEEDEDAVSEDGVESD 555

  Fly   572 YDFDEDYVIE 581
            .|.|||.|.|
plant   556 SDADEDAVSE 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ns1	NP_732199.2	GN3L_Grn1	17..88	CDD:285863	25/130 (19%)
		SurA_N_3	59..>150	CDD:304439	28/137 (20%)
		RbgA	121..443	CDD:224083	113/343 (33%)
		Nucleostemin_like	152..322	CDD:206753	64/169 (38%)
		Ras_like_GTPase	271..>400	CDD:206648	51/128 (40%)
AtNug2	NP_175706.1	NGP1NT	44..169	CDD:285379	26/138 (19%)
		RbgA	199..484	CDD:224083	109/310 (35%)
		NGP_1	208..364	CDD:206751	68/178 (38%)
		HARE-HTH	<533..573	CDD:294801	8/33 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1210675at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820