DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ns1 and NSN1

DIOPT Version :9

Sequence 1:	NP_732199.2	Gene:	Ns1 / 42060	FlyBaseID:	FBgn0038473	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_187361.1	Gene:	NSN1 / 819890	AraportID:	AT3G07050	Length:	582	Species:	Arabidopsis thaliana

Alignment Length:	596	Identity:	225/596 - (37%)
Similarity:	332/596 - (55%)	Gaps:	61/596 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LKRLKTKKSKRLTGRLKHKIEKKVRDHNKKERRAAKKNPKKGSKKQKLIQ----IPNICPFKDDI 63
            :||.|..||||:|.:.|||:.|||::|:||:.:.||   |.|..::..::    |||..|||:..
plant     2 VKRSKKSKSKRVTLKQKHKVLKKVKEHHKKKAKDAK---KLGLHRKPRVEKDPGIPNDWPFKEQE 63

  Fly    64 LK--EVEEAKQRQEAERLARREAFKAEREQNKFKTLESMVEDADMRSTVHGIMHENDAQDQDEKK 126
            ||  ||..|:..:|.|:  ::||.|...::.|.    .:|:|.|.::....|        :|..|
plant    64 LKALEVRRARALEEIEQ--KKEARKERAKKRKL----GLVDDEDTKTEGETI--------EDLPK 114

  Fly   127 YKNAVTKEQSLKQYFKEFRKVIENADVVLEVVDARDPLGTRCNEVERAVRGAPGNKRLVLVLNKA 191
            ..|  .::.|.:.::||..||||.:||:|||:||||||||||.::||.|..|..||.|||:|||.
plant   115 VVN--VRDNSERAFYKELVKVIELSDVILEVLDARDPLGTRCTDMERMVMQAGPNKHLVLLLNKI 177

  Fly   192 DLVPRENLNNWIKYFRRSGPVTAFKASTQDQANRLGRRKLREMKTEKAMQGSVCIGAELLMSMLG 256
            ||||||....|:.|.|...|..|||.|||:|.:.||.:..:..|....:|.|.|:||:.|:.:|.
plant   178 DLVPREAAEKWLMYLREEFPAVAFKCSTQEQRSNLGWKSSKASKPSNMLQTSDCLGADTLIKLLK 242

  Fly   257 NYCRNKGIKTSIRVGVVGIPNVGKSSIINSLTRGRSCMVGSTPGVTKSMQEVELDSKIKLIDCPG 321
            ||.|:..:|.||.||::|:|||||||:||||.|.....||:|||:|:|:|||.||..:||:||||
plant   243 NYSRSHELKKSITVGIIGLPNVGKSSLINSLKRAHVVNVGATPGLTRSLQEVHLDKNVKLLDCPG 307

  Fly   322 IV-FTSGGENSHAVLKNAQRVGDVKDPFTIAESVLKRASKEYFCTMYDITNYDTFEEFFAKKAAR 385
            :| ..|.|.::...|:|.:|:..:.||.:..:.:||...|:...|:|.|.:::..::|..|.|..
plant   308 VVMLKSSGNDASIALRNCKRIEKLDDPVSPVKEILKLCPKDMLVTLYKIPSFEAVDDFLYKVATV 372

  Fly   386 MGKFLKKGVPDVVAAARSVLNDWNTGKIKYCTQPPEVQEGQSVHISASIVHSEAREFDVENFESM 450
            .||..|.|:.|:.||||.||:|||.|||.|.|.||:..:|.  |..:.||...|::|:::...|.
plant   373 RGKLKKGGLVDIDAAARIVLHDWNEGKIPYYTMPPKRDQGG--HAESKIVTELAKDFNIDEVYSG 435

  Fly   451 ETEILEHCAVKTDDIME---ITSTGPLEI----------RQPREEAEPADKITASLVIDEKEKPA 502
            |:..:.  ::||.:...   |.|.|||..          .|..||||.......|:..:|:|:..
plant   436 ESSFIG--SLKTVNEFNPVIIPSNGPLNFDETMIEDESKTQTEEEAEHESDDDESMGGEEEEEAG 498

  Fly   503 KGRKRKLDEEKEKVDPSLLLEENQSLNKGIKQMQKLKKKQNVRNEKKISKITDVLDSFSLGPSSS 567
            | .|.|.:..::.|.   |......||   .:.||.:||:..:.:|..:...|::|.
plant   499 K-TKEKSETGRQNVK---LYAAESMLN---TKKQKAEKKKRKKAKKAGADEEDLMDG-------- 548

  Fly   568 KAEKYDFDEDY 578
               .|||..||
plant   549 ---DYDFKVDY 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ns1	NP_732199.2	GN3L_Grn1	17..88	CDD:285863	29/76 (38%)
		SurA_N_3	59..>150	CDD:304439	26/92 (28%)
		RbgA	121..443	CDD:224083	146/322 (45%)
		Nucleostemin_like	152..322	CDD:206753	92/169 (54%)
		Ras_like_GTPase	271..>400	CDD:206648	54/129 (42%)
NSN1	NP_187361.1	GN3L_Grn1	<44..88	CDD:285863	16/45 (36%)
		GTPase_YlqF	128..400	CDD:274669	131/271 (48%)
		Nucleostemin_like	138..308	CDD:206753	92/169 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	135	1.000	Domainoid score	I1619
eggNOG	1	0.900	-	-		E1_COG1161
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H133776
Inparanoid	1	1.050	351	1.000	Inparanoid score	I613
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1210675at2759
OrthoFinder	1	1.000	-	-		FOG0002318
OrthoInspector	1	1.000	-	-		oto4035
orthoMCL	1	0.900	-	-		OOG6_101399
Panther	1	1.100	-	-	LDO	PTHR11089
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1530
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.830