DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ns1 and gnl2

DIOPT Version :9

Sequence 1:	NP_732199.2	Gene:	Ns1 / 42060	FlyBaseID:	FBgn0038473	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_998389.1	Gene:	gnl2 / 793727	ZFINID:	ZDB-GENE-040426-2317	Length:	727	Species:	Danio rerio

Alignment Length:	559	Identity:	157/559 - (28%)
Similarity:	261/559 - (46%)	Gaps:	64/559 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 KKERRAAKKNPKKGSKKQKLIQIPNICPFKDDILKEVEEAKQRQEAERLARREAFKAEREQNKFK 95
            ::|..|.||:|.:...:|..:.:..:    .|.:|.........:.|........||:|::....
Zfish    96 QEEMNAVKKDPYRVVMRQSKLPMSLL----HDRIKAHNSKVHILDTETFETTFGPKAQRKRPNLS 156

  Fly    96 T--LESMVEDADMRSTVHGIMHENDAQDQD---EKKYKNAVTKEQSLKQYFKEFRKVIENADVVL 155
            .  |:...|.|::.:..:....:.|...:|   :::.:..:.|:...|:.:.|..|||:::||::
Zfish   157 VGELKEFAEQAEVSAQSYSAEKDRDLVSEDSGVKEEAREEIFKKGQSKRIWGELYKVIDSSDVII 221

  Fly   156 EVVDARDPLGTRCNEVERAVRGAPGNKRLVLVLNKADLVPRENLNNWIKYFRRSGPVTAFKASTQ 220
            :|:|||||:|||...:|..::.....|.|:.||||.||:|.....:|:....:..|..||.||.
Zfish   222 QVLDARDPMGTRSQSIETYLKKEKPWKHLIFVLNKCDLIPTWVTKHWVAVLSQEYPTLAFHASL- 285

  Fly   221 DQANRLGRRKLREMKTEKAMQGSVCIGAELLMSMLGNYCRNKGIKTSIRVGVVGIPNVGKSSIIN 285
              .|..|:             ||       |:.:|..:.:....|..|.||.:|.||||||||||
Zfish   286 --TNSFGK-------------GS-------LIQLLRQFGKLHSDKKQISVGFIGYPNVGKSSIIN 328

  Fly   286 SLTRGRSCMVGSTPGVTKSMQEVELDSKIKLIDCPGIVFTSGGENSHAVLKNAQRVGDVKDPFTI 350
            :|...:.|.|....|.||..|.:.|..:|.||||||:|:.|....:..|||...:|..:::|...
Zfish   329 TLRSKKVCNVAPLAGETKVWQYITLMRRIFLIDCPGVVYPSDDSETDIVLKGVVQVEKIRNPEDH 393

  Fly   351 AESVLKRASKEYFCTMYDITNYDTFEEFFAKKAARMGKFLKKGVPDVVAAARSVLNDWNTGKIKY 415
            ..:||:||..||....|.|.::.:.|:|..|.|.|.||.||.|.||:...::.|||||..|:|.:
Zfish   394 IGAVLERAKAEYIQKTYRIPSWSSAEDFLEKLAFRTGKLLKGGEPDLPTVSKMVLNDWQRGRIPF 458

  Fly   416 CTQPPEVQEGQSVHISASI----VHSEAREF-------DVENFESMETEILEHCAVKTDDIMEI- 468
            ..:||.|:..:.....|.:    :.||..|.       |||...|.:.|..:....|.:::.::
Zfish   459 FVKPPGVETDEENKAQAMLEMPEMESEMDELENRLEAQDVEEASSSQHEEQKLLKKKKEEVQKLF 523

  Fly   469 ----TSTGPLEIRQPREE-----AEPADKITASLVIDEKEKPAKGRKRKLDEEKEKVDPSLLLEE 524
                .:.|.:.:.....|     .|..|.:.||...||:.:  :..:.:.||||.:.:.....||
Zfish   524 NDVKQNFGKINVAPEFSEEDLVPVEMPDMMDASGSEDEENE--EEEEEEDDEEKAEEETGEQQEE 586

  Fly   525 NQSLN-----KGIKQMQKLKKKQNVRNEKKISKITDVLD 558
            ..|::     .|.|..|::.|:.    ::||:|:...||
Zfish   587 ESSVSDSTPKAGKKSTQEVNKEM----DEKIAKLKHFLD 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ns1	NP_732199.2	GN3L_Grn1	17..88	CDD:285863	10/56 (18%)
		SurA_N_3	59..>150	CDD:304439	17/95 (18%)
		RbgA	121..443	CDD:224083	111/335 (33%)
		Nucleostemin_like	152..322	CDD:206753	62/169 (37%)
		Ras_like_GTPase	271..>400	CDD:206648	54/128 (42%)
gnl2	NP_998389.1	NGP1NT	44..174	CDD:285379	15/81 (19%)
		RbgA	198..475	CDD:224083	106/299 (35%)
		NGP_1	209..365	CDD:206751	66/178 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1210675at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920