DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ns1 and gnl1

DIOPT Version :9

Sequence 1:	NP_732199.2	Gene:	Ns1 / 42060	FlyBaseID:	FBgn0038473	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001072441.1	Gene:	gnl1 / 779895	XenbaseID:	XB-GENE-481292	Length:	612	Species:	Xenopus tropicalis

Alignment Length:	661	Identity:	146/661 - (22%)
Similarity:	249/661 - (37%)	Gaps:	185/661 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MALKRLKTKKSKRLTGRLKHKIEKKVRDHNKKERRAAKKNPKKGSKK------------------ 47
            |..|:..:.|.|:     |...:|:.|.....|:..|:.|.:.||::
Frog     1 MPRKKPFSNKQKK-----KQLQDKRERKRGPSEQGRAESNSRSGSRERWEENTDTSDSESLRPQL 60

  Fly    48 QKLIQIPNICPFKDDILKEVEEAKQRQEAERLARREAFKAEREQNKFKTLESMVE---DADMRST 109
            :::.|.|.|  ||..      |........||...:..|.|.||.|...||.::|   ::::...
Frog    61 RRVNQQPQI--FKPG------ERNYDPNRYRLYFEKETKEEIEQRKKIALEKILEPVPESELEVH 117

  Fly   110 VHGI------------------MHENDAQDQDEKKYKNAVTK-------------EQSLKQYFKE 143
            :..|                  |.:...|.::||.:|..:.|             :.:|:.: ::
Frog   118 IDQIYRPGSVLDFPKRPAWTYEMSKEAVQSREEKAFKEYLQKIYESHNPRELSYFDHNLETW-RQ 181

  Fly   144 FRKVIENADVVLEVVDARDPLGTRCNEVERAVRGAPG---------NKRLVLVLNKADLVPRENL 199
            ..:|:|.:|::|.:.|.|.|:          :..:|.         .:.|:|||||.||.|...:
Frog   182 LWRVLEMSDIILLITDIRHPV----------LHFSPALYDYVTQELGRSLILVLNKTDLAPPSLV 236

  Fly   200 NNWIKYFRRSGP------VTAFKASTQDQAN-----RLGRRKLR----EMKTEKAMQGSVCIGAE 249
            ..|..||:...|      .|::....:::.:     :..|||.|    .:...:.::....|.||
Frog   237 VAWKHYFQAKFPKVHVVCFTSYPRHPEEEQDPSAVFKKRRRKRRVWSSALGPSQLLRACEVITAE 301

  Fly   250 LL------------MSMLGNYCRNKGIKTS------------------------------IRVGV 272
            .:            .:.|.|....:|.:..                              :.:|.
Frog   302 KVDLTSWREKIERDSAALCNPASEEGTQDEETDELNAVVSHQITDAELGAPSSELYKDGVLSIGC 366

  Fly   273 VGIPNVGKSSIINSLTRGRSCMVGSTPGVTKSMQEVELDSKIKLIDCPGIVFTSGGENSHAVLKN 337
            ||.|||||||:||.|...:...|..|||.||..|...|...::|.||||::|.|..:....:|..
Frog   367 VGFPNVGKSSLINGLVGKKIVSVSRTPGHTKYFQTYYLTPTVRLCDCPGLIFPSLIDRQQQILAG 431

  Fly   338 AQRVGDVKDPFTI---------AESVLK---RASKEYFCTMYDITNYDTFEEFFAKKAARMGKFL 390
            ...:..:::|:|.         ...:||   .:..|...|.:.|.      |.:|.|  |..|..
Frog   432 IYPIAQIQEPYTSVGYLSCRIPVPQLLKLPQPSGVEGGWTAWSIC------EAWADK--RGYKTA 488

  Fly   391 KKGVPDVVAAARSVLNDWNTGKIKYCTQPPEVQEGQSVHISASIVHSEAREFDVENFESMETEIL 455
            |....|...||.|:|.....|::..|.:||    |.||...|...|.|.:|..|.: ::......
Frog   489 KASRSDTYRAANSLLRLAVDGRLCLCMRPP----GYSVQKEAWQQHPETKEMAVHS-QAQGQANN 548

  Fly   456 EHCAVKTDDIMEITSTGPLEIRQPREEAEPADKITASLVIDEKEKPA-----KGRKRKLDEEKEK 515
            :..:.:.::..||:|:|..|..|.|:..|..         ||:|.|.     :|.|.|:.:
Frog   549 DPSSGREEEEEEISSSGEEEEEQDRDADEEE---------DEEEDPTQSQHKRGNKNKVTD---- 600

  Fly   516 VDPSLLLEENQ 526
            ::|..||.|::
Frog   601 INPFELLGEDE 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ns1	NP_732199.2	GN3L_Grn1	17..88	CDD:285863	17/88 (19%)
		SurA_N_3	59..>150	CDD:304439	22/124 (18%)
		RbgA	121..443	CDD:224083	95/412 (23%)
		Nucleostemin_like	152..322	CDD:206753	55/235 (23%)
		Ras_like_GTPase	271..>400	CDD:206648	43/140 (31%)
gnl1	NP_001072441.1	RbgA	174..513	CDD:224083	81/357 (23%)
gnl1	NP_001072441.1	HSR1_MMR1	178..419	CDD:206750	58/251 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000