DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ns1 and LSG1

DIOPT Version :9

Sequence 1:	NP_732199.2	Gene:	Ns1 / 42060	FlyBaseID:	FBgn0038473	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_060855.2	Gene:	LSG1 / 55341	HGNCID:	25652	Length:	658	Species:	Homo sapiens

Alignment Length:	678	Identity:	135/678 - (19%)
Similarity:	226/678 - (33%)	Gaps:	250/678 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LKTKKSKRLTGRLKHKIEKKVRDHNKKERRAAKKNPKKGSKKQKLIQIPNICPFKDDILKEVEEA 70
            |..::|:|:         ||:.:.||:....    |::.:..|      |..|         ||.
Human    92 LSFEESQRI---------KKLHEENKQFLCI----PRRPNWNQ------NTTP---------EEL 128

  Fly    71 KQRQEAERLA-RREAFKAEREQNKFKTLESMVEDADMRSTVHGIMHENDAQDQDEKKYKNAVTKE 134
            ||.::...|. ||:..:.|.||                                    |..:|..
Human   129 KQAEKDNFLEWRRQLVRLEEEQ------------------------------------KLILTPF 157

  Fly   135 QSLKQYFKEFRKVIENADVVLEVVDARDPLGTRCNEVERAVRGAPGNKRLVLVLNKADLVPRENL 199
            :....::::..:|||.:|:|:::||||:||..||.::|..|:....||..|:::|||||:..|..
Human   158 ERNLDFWRQLWRVIERSDIVVQIVDARNPLLFRCEDLECYVKEMDANKENVILINKADLLTAEQR 222

  Fly   200 NNWIKYFRRSGPVTAF----------KASTQDQANRLGRR------------------------- 229
            :.|..||.:......|          ...::::|||..|:
Human   223 SAWAMYFEKEDVKVIFWSALAGAIPLNGDSEEEANRDDRQSNTTKFGHSSFDQAEISHSESEHLP 287

  Fly   230 ---------------------------------------------------------KLREMKTE 237
                                                                     :.|..||.
Human   288 ARDSPSLSENPTTDEDDSEYEDCPEEEEDDWQTCSEEDGPKEEDCSQDWKESSTADSEARSRKTP 352

  Fly   238 KAMQ---GSVCIGAELLMSMLGNYCRNKGIKT-SIRVGVVGIPNVGKSSIINSLTRGRSCMVGST 298
            :..|   .|..:..:.|:.:.......:.:|. .:.||:||.|||||||.||::...:...|.:|
Human   353 QKRQIHNFSHLVSKQELLELFKELHTGRKVKDGQLTVGLVGYPNVGKSSTINTIMGNKKVSVSAT 417

  Fly   299 PGVTKSMQEVELDSKIKLIDCPGIVFTS-GGENSHAVLKNAQRVGDVKDPFTIAESVLKRASKEY 362
            ||.||..|.:.::..:.|.||||:|..| ....:.........:..::|.......|.:...:..
Human   418 PGHTKHFQTLYVEPGLCLCDCPGLVMPSFVSTKAEMTCSGILPIDQMRDHVPPVSLVCQNIPRHV 482

  Fly   363 FCTMYDIT-----------NYDTFEEFFAKKAARMGKFLKKGVPDVVAAARSVLNDWNTGKIKYC 416
            ....|.|.           ...|.||.........|.....|.||...:||.:|.|:.:||:.||
Human   483 LEATYGINIITPREDEDPHRPPTSEELLTAYGYMRGFMTAHGQPDQPRSARYILKDYVSGKLLYC 547

  Fly   417 TQPPEVQEGQSVHISASIVHSEAREFDVENFESMETEILEHCAVKTDDIMEITSTGPLEIRQPRE 481
            ..||    |:                |...|:.....:||: .:.:|:|
Human   548 HPPP----GR----------------DPVTFQHQHQRLLEN-KMNSDEI---------------- 575

  Fly   482 EAEPADKITASLVIDEKEKPAKGRKRKLDEEKEKVDPSLLLEEN-QSLNKGIKQMQKLK------ 539
                              |...||.:|..:.:..||.:...:|| ::|.||::.:...|
Human   576 ------------------KMQLGRNKKAKQIENIVDKTFFHQENVRALTKGVQAVMGYKPGSGVV 622

  Fly   540 ---------------KKQNVRNEKKISK 552
                           ||...||:|:.|:
Human   623 TASTASSENGAGKPWKKHGNRNKKEKSR 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ns1	NP_732199.2	GN3L_Grn1	17..88	CDD:285863	15/71 (21%)
		SurA_N_3	59..>150	CDD:304439	14/91 (15%)
		RbgA	121..443	CDD:224083	90/429 (21%)
		Nucleostemin_like	152..322	CDD:206753	60/265 (23%)
		Ras_like_GTPase	271..>400	CDD:206648	37/140 (26%)
LSG1	NP_060855.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
		RbgA	151..554	CDD:224083	90/422 (21%)
		HSR1_MMR1	163..444	CDD:206750	65/280 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..355		7/104 (7%)
		P-loop_NTPase	366..>404	CDD:304359	13/37 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	623..658		6/28 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810