DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ns1 and GNL3L

DIOPT Version :9

Sequence 1:NP_732199.2 Gene:Ns1 / 42060 FlyBaseID:FBgn0038473 Length:581 Species:Drosophila melanogaster
Sequence 2:NP_001171748.1 Gene:GNL3L / 54552 HGNCID:25553 Length:582 Species:Homo sapiens


Alignment Length:607 Identity:219/607 - (36%)
Similarity:312/607 - (51%) Gaps:105/607 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 RLKHKIEKKVRDHNKKERR-------AAKKNPKKGSKKQKLIQIPNICPF--------KDDILKE 66
            :|:|| .||..:.:|..::       .||:|.||.:.|     :|:...|        ::..||:
Human     3 KLRHK-NKKPGEGSKGHKKISWPYPQPAKQNGKKATSK-----VPSAPHFVHPNDHANREAELKK 61

  Fly    67 --VEEAKQRQEAERLARREAFKAEREQNKFKTLESMVEDADMRSTVHGIMHENDAQDQDEKKYKN 129
              |||.:::|:|.|         |:|:.|.:|:||..:|...|              |:|.::|.
Human    62 KWVEEMREKQQAAR---------EQERQKRRTIESYCQDVLRR--------------QEEFEHKE 103

  Fly   130 AVTKEQSL----------KQYFKEFRKVIENADVVLEVVDARDPLGTRCNEVERAVRGAPGNKRL 184
            .|.:|.::          |.|:||||||:|.:||:|||:|||||||.||.::|.||..|.|||:|
Human   104 EVLQELNMFPQLDDEATRKAYYKEFRKVVEYSDVILEVLDARDPLGCRCFQMEEAVLRAQGNKKL 168

  Fly   185 VLVLNKADLVPRENLNNWIKYFRRSGPVTAFKASTQDQANRLGRRKLR-EMKTEKAMQGSVCIGA 248
            ||||||.||||:|.:..|:.|.|...|..|||||||.|...|.|..:. :..:|..::...|.||
Human   169 VLVLNKIDLVPKEVVEKWLDYLRNELPTVAFKASTQHQVKNLNRCSVPVDQASESLLKSKACFGA 233

  Fly   249 ELLMSMLGNYCRNKGIKTSIRVGVVGIPNVGKSSIINSLTRGRSCMVGSTPGVTKSMQEVELDSK 313
            |.||.:||||||...::|.|||||||:|||||||:||||.|.|:|.||:.||:||.||||.||..
Human   234 ENLMRVLGNYCRLGEVRTHIRVGVVGLPNVGKSSLINSLKRSRACSVGAVPGITKFMQEVYLDKF 298

  Fly   314 IKLIDCPGIVFTSGGENSH--AVLKNAQRVGDVKDPFTIAESVLKRASKEYFCTMYDITNYDTFE 376
            |:|:|.||||   .|.||.  .:|:|...|..:.||.|..|::|:|.:.|.....|.::.:.|.|
Human   299 IRLLDAPGIV---PGPNSEVGTILRNCVHVQKLADPVTPVETILQRCNLEEISNYYGVSGFQTTE 360

  Fly   377 EFFAKKAARMGKFLKKGVPDVVAAARSVLNDWNTGKIKYCTQPPEVQEGQSVHISASIVHSEARE 441
            .|....|.|:||..|.|:.....||::||.||.:|||.:...||.... ...|:||.||......
Human   361 HFLTAVAHRLGKKKKGGLYSQEQAAKAVLADWVSGKISFYIPPPATHT-LPTHLSAEIVKEMTEV 424

  Fly   442 FDVENFESMETEILEHCAVKTDDIMEITSTGPLE-----IRQPREEAEPA--DKITASLVID--- 496
            ||:|:.|....:.:|..|....|.: :..|.|||     :..|..:...|  :|.|...:.|   
Human   425 FDIEDTEQANEDTMECLATGESDEL-LGDTDPLEMEIKLLHSPMTKIADAIENKTTVYKIGDLTG 488

  Fly   497 ---EKEKPAKG-RKRKLDEEKE--------------------KVDPSLLLEENQSLNKGIKQMQK 537
               ...:...| .||.:|...:                    :.||   |::.|:|...:|.   
Human   489 YCTNPNRHQMGWAKRNVDHRPKSNSMVDVCSVDRRSVLQRIMETDP---LQQGQALASALKN--- 547

  Fly   538 LKKKQNVRNEKKISKITDVLDS 559
             |||...|.:|..||::|.:.|
Human   548 -KKKMQKRADKIASKLSDSMMS 568

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ns1NP_732199.2 GN3L_Grn1 17..88 CDD:285863 22/87 (25%)
SurA_N_3 59..>150 CDD:304439 30/110 (27%)
RbgA 121..443 CDD:224083 154/334 (46%)
Nucleostemin_like 152..322 CDD:206753 98/170 (58%)
Ras_like_GTPase 271..>400 CDD:206648 60/130 (46%)
GNL3LNP_001171748.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..58 14/60 (23%)
Required for nucleolar localization 9..35 6/25 (24%)
Nucleostemin_like 136..307 CDD:206753 98/170 (58%)
MnmE_helical 251..>405 CDD:331155 74/156 (47%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 144 1.000 Domainoid score I4626
eggNOG 1 0.900 - - E1_COG1161
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 304 1.000 Inparanoid score I2664
Isobase 1 0.950 - 0 Normalized mean entropy S2133
OMA 1 1.010 - - QHG48761
OrthoDB 1 1.010 - - D1210675at2759
OrthoFinder 1 1.000 - - FOG0002318
OrthoInspector 1 1.000 - - oto88621
orthoMCL 1 0.900 - - OOG6_101399
Panther 1 1.100 - - LDO PTHR11089
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R524
SonicParanoid 1 1.000 - - X1530
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.820

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