DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ns1 and Gnl2

DIOPT Version :9

Sequence 1:	NP_732199.2	Gene:	Ns1 / 42060	FlyBaseID:	FBgn0038473	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001020907.1	Gene:	Gnl2 / 362593	RGDID:	1305006	Length:	734	Species:	Rattus norvegicus

Alignment Length:	671	Identity:	179/671 - (26%)
Similarity:	270/671 - (40%)	Gaps:	197/671 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KSKRLTGRLKHKIEKKVRDHNKK------ERRAAKKNPKKGSKKQKLIQIPNICPFKDDILKEVE 68
            |..:|...|.|   .:|:.||.|      |...:...||...|:      ||:  |..|:...:|
  Rat   112 KQSKLPMSLLH---DRVQPHNAKVHILDTESFESTFGPKSQRKR------PNL--FASDMQSLLE 165

  Fly    69 EAKQRQEAERLARREAFKAEREQNKFKTLESMVEDADMRSTVHGIMHENDAQDQDEKKYKNAVTK 133
            .|:...|:            .:|.|.:.|  :.||..:|         |:||   |:.||    |
  Rat   166 NAEMSTES------------YDQGKDRDL--VTEDTGVR---------NEAQ---EEIYK----K 200

  Fly   134 EQSLKQYFKEFRKVIENADVVLEVVDARDPLGTRCNEVERAVRGAPGNKRLVLVLNKADLVPREN 198
            .|| |:.:.|..|||:::|||::|:|||||:|||.:.:|..::.....|.|:.||||.||||...
  Rat   201 GQS-KRIWGELYKVIDSSDVVVQVLDARDPMGTRSSHIEAYLKKEKPWKHLIFVLNKCDLVPTWA 264

  Fly   199 LNNWIKYFRRSGPVTAFKASTQDQANRLGRRKLREMKTEKAMQGSVCIGAELLMSMLGNYCRNKG 263
            ...|:....:..|..||.||.   .|..|:                  ||  .:.:|..:.:...
  Rat   265 TKRWVAVLSKDYPTLAFHASL---TNPFGK------------------GA--FIQLLRQFGKLHT 306

  Fly   264 IKTSIRVGVVGIPNVGKSSIINSLTRGRSCMVGSTPGVTKSMQEVELDSKIKLIDCPGIVFTSGG 328
            .|..|.||.:|.|||||||:||:|...:.|.|....|.||..|.:.|..:|.||||||:|:.|..
  Rat   307 DKKQISVGFIGYPNVGKSSVINTLRSKKVCNVAPIAGETKVWQYITLMRRIFLIDCPGVVYPSED 371

  Fly   329 ENSHAVLKNAQRVGDVKDPFTIAESVLKRASKEYFCTMYDITNYDTFEEFFAKKAARMGKFLKKG 393
            ..:..|||...:|..:|.|.....:||:||..||....|.|.:::..|:|..|.|.|.||.||.|
  Rat   372 SETDIVLKGVVQVEKIKAPQDHIGAVLERAKPEYISKTYKIESWENAEDFLEKLALRTGKLLKGG 436

  Fly   394 VPDVVAAARSVLNDWNTGKIKYCTQPPEVQEGQSVHISASI---VHSEAREFDVENFESMETEIL 455
            .||::..::.|||||..|:|.:..:||..:...:..:..|.   |.:|..:.:.|. |::|||:.
  Rat   437 EPDLLTVSKMVLNDWQRGRIPFFVKPPNAEMPTTPQLPPSSPLEVTTETTQNNPEE-ETIETEVE 500

  Fly   456 EHCAV-------------------------------------KTDDIMEITSTGPLEI------- 476
            ...:|                                     ..||::.:....|:::
  Rat   501 RSDSVIEKEPEAGCSQDENSEMQQILARVRQNFGKINVGPQFSADDLVPVDDLVPVDLSDLEDLE 565

  Fly   477 ----------RQPREEAE----------PADKITASLV--IDEK-------EKPAKGRK------ 506
                      .||.|:||          |.:..|.:::  :|||       ...||.:|
  Rat   566 SSEEEEEQEQEQPGEDAEEECSRDTRGGPVEDDTKAVIRALDEKIAKYQRFLNKAKAKKFSAIRI 630

  Fly   507 ---------RKLDEEK---------------------------EKVDPSLLLEE-------NQSL 528
                     .|.:|||                           :|....|..:|       .||.
  Rat   631 SKDLSEKVFAKYEEEKKASAEVSDAAPTKRARKWNAQVEEEPSDKTQRMLTCKERRRAARQQQSK 695

  Fly   529 NKGIKQMQKLKKKQNVRNEKK 549
            ..|::..:....|...||:||
  Rat   696 KVGVRYYETHNVKNRNRNKKK 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ns1	NP_732199.2	GN3L_Grn1	17..88	CDD:285863	17/76 (22%)
		SurA_N_3	59..>150	CDD:304439	25/90 (28%)
		RbgA	121..443	CDD:224083	114/324 (35%)
		Nucleostemin_like	152..322	CDD:206753	62/169 (37%)
		Ras_like_GTPase	271..>400	CDD:206648	54/128 (42%)
Gnl2	NP_001020907.1	NGP1NT	44..174	CDD:285379	19/84 (23%)
		RbgA	190..488	CDD:224083	118/337 (35%)
		NGP_1	209..365	CDD:206751	66/178 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1210675at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820