DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ns1 and gnl3

DIOPT Version :9

Sequence 1:	NP_732199.2	Gene:	Ns1 / 42060	FlyBaseID:	FBgn0038473	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001002297.1	Gene:	gnl3 / 321897	ZFINID:	ZDB-GENE-030131-616	Length:	561	Species:	Danio rerio

Alignment Length:	602	Identity:	189/602 - (31%)
Similarity:	314/602 - (52%)	Gaps:	66/602 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LKRLKTKK-SKRLTGRLKHKIEKKVRDHNKKERRAAKKNPKKG--SKKQKLIQIPNICPFKDDIL 64
            :||.|.|| ||||:...::||:||||:||:|.::|||   |:|  .|.:|.|.:||..|||:::|
Zfish     1 MKRPKLKKASKRLSCAKRYKIQKKVREHNRKLKKAAK---KQGISRKAKKDIGVPNSAPFKEEVL 62

  Fly    65 KEVEEAKQR----QEAERLARREAFKAEREQNKFKTLESMVEDADMRSTVHGIMHENDAQDQDEK 125
            :|.|:.||.    :|..::.:::...|:|::.|           |..|:|.....:...:....|
Zfish    63 REAEQRKQELETLKEQNKIVKQQEKAAKRKKEK-----------DAASSVKEPAAKKAKKAAKIK 116

  Fly   126 KYKNAVTKEQSLKQY-FKEFRKVIENADVVLEVVDARDPLGTRCNEVERAVRGAPGNKRLVLVLN 189
            :.:.|:.|.:|.|.: .:|..||||.:||::||:|||||||.||.::|..|....|.|:|:.:||
Zfish   117 EARAAIVKVKSAKTFKCQELNKVIEASDVIVEVLDARDPLGCRCPQLEEMVLKHEGKKKLLFILN 181

  Fly   190 KADLVPRENLNNWIKYFRRSGPVTAFKASTQDQANRLGRRKLREMKTEKAM---QGSVCIGAELL 251
            |.||||::||..|:.:.....|...||:|.| ..:|..::|.::..|...:   :.:.|.|.:.|
Zfish   182 KIDLVPKDNLEKWLHFLEAECPTFLFKSSMQ-LKDRTVQQKRQQRGTNAVLDHSRAASCFGKDFL 245

  Fly   252 MSMLGNYCRNKGIKTSIRVGVVGIPNVGKSSIINSLTRGRSCMVGSTPGVTKSMQEVELDSKIKL 316
            :..|.:....|..:|.::|||||.||||||||||||...|:|..|...|:|:.||||.:..|:|:
Zfish   246 LQTLNDLANKKEGETMLKVGVVGFPNVGKSSIINSLKEMRACNAGVQRGLTRCMQEVHITKKVKM 310

  Fly   317 IDCPGIVFTSGGENSHAVLKNAQRVGDVKDPFTIAESVLKRASKEYFCTMYDITNYDTFEEFFAK 381
            ||.|||:.......|...|::.|.....:.|.....::||:.::::....|::.:|.:..||...
Zfish   311 IDSPGILAALSNPGSAMALRSLQVEEKEESPQEAVRNLLKQCNQQHVMLQYNVPDYRSSLEFLTT 375

  Fly   382 KAARMGKFLKKGVPDVVAAARSVLNDWNTGKIKYCTQPPEVQEGQSVHISASIVHSEAREFDV-- 444
            .|.:.|...|.||.|...||.:.||||...|:.|.::.|| ::|...::|.:||.....:.|:
Zfish   376 FAMKHGLLQKGGVADTELAATTFLNDWTGAKLSYYSRVPE-RQGLPSYLSDAIVTELQSDVDMDA 439

  Fly   445 -----ENFE-SMETEILEHCAVKTDDIMEITSTGPLEIRQPREEAEPADKITASLVIDEKEKPAK 503
                 ||.: |:....|..|       :...|:||                ||. |:|..|.|.:
Zfish   440 VKKGNENVKRSVRFPNLASC-------ISFDSSGP----------------TAG-VLDVSELPKE 480

  Fly   504 ---GRKRKLDEEKEKVDPSLLLEENQS---LNKGIKQMQKLKKKQNVRNEKKISKITDVLDSFSL 562
               ......|.|:||:|.:...:|.::   ::..::.:|:..:|:..:..|:: |...|....:.
Zfish   481 ILTKAATTTDAEEEKMDTTTNTDEPEAESHISSTVEPIQEPTEKRKDKPAKEV-KFVPVNTDLTS 544

  Fly   563 GPSSSKAEKYDFDEDYV 579
            ..:.:..:.|||:.|:|
Zfish   545 MQNKNNEDAYDFNTDFV 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ns1	NP_732199.2	GN3L_Grn1	17..88	CDD:285863	28/76 (37%)
		SurA_N_3	59..>150	CDD:304439	23/95 (24%)
		RbgA	121..443	CDD:224083	115/325 (35%)
		Nucleostemin_like	152..322	CDD:206753	73/172 (42%)
		Ras_like_GTPase	271..>400	CDD:206648	48/128 (38%)
gnl3	NP_001002297.1	GN3L_Grn1	17..85	CDD:285863	28/70 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..58		14/32 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	76..110		7/44 (16%)
		GTPase_YlqF	128..411	CDD:274669	105/283 (37%)
		Nucleostemin_like	144..316	CDD:206753	73/172 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	486..532		8/45 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	89	1.000	Domainoid score	I7833
eggNOG	1	0.900	-	-		E1_COG1161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1210675at2759
OrthoFinder	1	1.000	-	-		FOG0002318
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101399
Panther	1	1.100	-	-	O	PTHR11089
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R524
SonicParanoid	1	1.000	-	-		X1530
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.810