DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ns1 and GNL2

DIOPT Version :9

Sequence 1:	NP_732199.2	Gene:	Ns1 / 42060	FlyBaseID:	FBgn0038473	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001310552.1	Gene:	GNL2 / 29889	HGNCID:	29925	Length:	799	Species:	Homo sapiens

Alignment Length:	676	Identity:	191/676 - (28%)
Similarity:	275/676 - (40%)	Gaps:	179/676 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KSKRLTGRLKHKIEKKVRDHNKK------ERRAAKKNPKKGSKKQKLIQIPNICPFKDDILKEVE 68
            |..:|...|.|   .::|.||.|      |.......||...|:      ||:  |..|:...:|
Human   112 KQSKLPMSLLH---DRIRPHNLKVHILDTESFETTFGPKSQRKR------PNL--FASDMQSLIE 165

  Fly    69 EAKQRQEAERLARREAFKAEREQNKFKTLESMVEDADMRSTVHGIMHENDAQDQDEKKYKNAVTK 133
            .|:...|:            .:|.|.:.|  :.||..:|         |:||   |:.||    |
Human   166 NAEMSTES------------YDQGKDRDL--VTEDTGVR---------NEAQ---EEIYK----K 200

  Fly   134 EQSLKQYFKEFRKVIENADVVLEVVDARDPLGTRCNEVERAVRGAPGNKRLVLVLNKADLVPREN 198
            .|| |:.:.|..|||:::|||::|:|||||:|||...:|..::.....|.|:.||||.||||...
Human   201 GQS-KRIWGELYKVIDSSDVVVQVLDARDPMGTRSPHIETYLKKEKPWKHLIFVLNKCDLVPTWA 264

  Fly   199 LNNWIKYFRRSGPVTAFKASTQDQANRLGR----RKLREM-----KTEKAM---QGSVCI----- 246
            ...|:....:..|..||.||.   .|..|:    :.||:.     .|..|:   .|.:||
Human   265 TKRWVAVLSQDYPTLAFHASL---TNPFGKGAFIQLLRQFGKPWHLTFHALLGFPGLLCILCPWS 326

  Fly   247 -------------------------------GAELLMSMLGNYCRNKGIKTSIRVGVVGIPNVGK 280
                                           |..|...:|...|.....|..|.||.:|.|||||
Human   327 PCSFYVLWLERALPKFKLQIPGQTSAPEGSRGTRLPYQILKASCSLHTDKKQISVGFIGYPNVGK 391

  Fly   281 SSIINSLTRGRSCMVGSTPGVTKSMQEVELDSKIKLIDCPGIVFTSGGENSHAVLKNAQRVGDVK 345
            ||:||:|...:.|.|....|.||..|.:.|..:|.||||||:|:.|....:..|||...:|..:|
Human   392 SSVINTLRSKKVCNVAPIAGETKVWQYITLMRRIFLIDCPGVVYPSEDSETDIVLKGVVQVEKIK 456

  Fly   346 DPFTIAESVLKRASKEYFCTMYDITNYDTFEEFFAKKAARMGKFLKKGVPDVVAAARSVLNDWNT 410
            .|.....:||:||..||....|.|.:::..|:|..|.|.|.||.||.|.||:....:.|||||..
Human   457 SPEDHIGAVLERAKPEYISKTYKIDSWENAEDFLEKLAFRTGKLLKGGEPDLQTVGKMVLNDWQR 521

  Fly   411 GKIKYCTQPPEVQ--------EGQSVHISASIVHS----EAREFDVENFESM---ETEILEHCAV 460
            |:|.:..:||..:        ...|:.:......:    |..|...|..||:   |||...||..
Human   522 GRIPFFVKPPNAEPLVAPQLLPSSSLEVVPEAAQNNPGEEVTETAGEGSESIIKEETEENSHCDA 586

  Fly   461 KT------------------------DDIMEITSTGPLEIRQPREEAEPADKITASLVIDEKEKP 501
            .|                        ||::      |:|:....||.|...        ||:|:
Human   587 NTEMQQILTRVRQNFGKINVVPQFSGDDLV------PVEVSDLEEELESFS--------DEEEE- 636

  Fly   502 AKGRKRKLDEEKEKVDPSLLLEEN---------QSLNKGIKQMQKL------KKKQNVRNEKKIS 551
             :..:::.|.|:...:|.   |||         ::|::.|.:.||.      ||...||..|.:|
Human   637 -EQEQQRDDAEESSSEPE---EENVGNDTKAVIKALDEKIAKYQKFLDKAKAKKFSAVRISKGLS 697

  Fly   552 -KITDVLDSFSLGPSSSKAEKYDFDE 576
             ||      |:......|..:.|.|:
Human   698 EKI------FAKPEEQRKTLEEDVDD 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ns1	NP_732199.2	GN3L_Grn1	17..88	CDD:285863	17/76 (22%)
		SurA_N_3	59..>150	CDD:304439	25/90 (28%)
		RbgA	121..443	CDD:224083	122/381 (32%)
		Nucleostemin_like	152..322	CDD:206753	70/217 (32%)
		Ras_like_GTPase	271..>400	CDD:206648	54/128 (42%)
GNL2	NP_001310552.1	NGP1NT	44..174	CDD:285379	19/84 (23%)
		RbgA	190..534	CDD:224083	123/363 (34%)
		NGP_1	209..433	CDD:206751	74/226 (33%)
		AtpF	661..>756	CDD:223783	16/63 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1210675at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820