DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ns1 and Lsg1

DIOPT Version :9

Sequence 1:	NP_732199.2	Gene:	Ns1 / 42060	FlyBaseID:	FBgn0038473	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001013439.1	Gene:	Lsg1 / 288029	RGDID:	1309089	Length:	655	Species:	Rattus norvegicus

Alignment Length:	620	Identity:	124/620 - (20%)
Similarity:	209/620 - (33%)	Gaps:	233/620 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 EEAKQRQEAERLA-RREAFKAEREQNKFKTLESMVEDADMRSTVHGIMHENDAQDQDEKKYKNAV 131
            ||.||.::...|. ||:..:.|.||                                    |..:
  Rat   126 EELKQAEKDNFLKWRRQLVRLEEEQ------------------------------------KLIL 154

  Fly   132 TKEQSLKQYFKEFRKVIENADVVLEVVDARDPLGTRCNEVERAVRGAPGNKRLVLVLNKADLVPR 196
            |..:....::::..:|||.:|:|:::||||:||..||.::|..|:.....|..|:::|||||:..
  Rat   155 TPFERNLDFWRQLWRVIERSDIVVQIVDARNPLLFRCEDLECYVKEIDAAKENVILINKADLLTA 219

  Fly   197 ENLNNWIKYFRRSGPVTAF--------------------------KASTQDQA---NRLGRRKL- 231
            |....|..:|.:.|....|                          .:.::|.:   |.:..|.|
  Rat   220 EQRVAWAVHFEKEGVKVIFWSALAETVHLNGDSKDEVNSVAGEANSSESEDSSLDGNEIPHRDLF 284

  Fly   232 -------------------------------REMKTEKAMQGSVC-------------------- 245
                                           .:...|:..:...|
  Rat   285 LLSEESESDDDDSEYEDCQEDEEEDWQTCSEEDSNPEEGQEEGGCDRDQKEHGPEDSEAQSRASP 349

  Fly   246 -----------IGAELLMSMLGNYCRNKGIKT-SIRVGVVGIPNVGKSSIINSLTRGRSCMVGST 298
                       :..:.|:.:.......|.:|. .:.||:||.|||||||.||::...:...|.:|
  Rat   350 ENSQMSNKSHLVSKQELLELFKKLHTGKKVKDGQLTVGLVGYPNVGKSSTINTIMGNKKVSVSAT 414

  Fly   299 PGVTKSMQEVELDSKIKLIDCPGIVFTS-GGENSHAVLKNAQRVGDVKD------------PFTI 350
            ||.||..|.:.::..:.|.||||:|..| ....:..:......:..::|            |..:
  Rat   415 PGHTKHFQTLYVEPGLCLCDCPGLVMPSFVSTKAEMICSGILPIDQMRDHVPPVSLVCQNIPRRV 479

  Fly   351 AE-----SVLKRASKEYFCTMYDITNYDTFEEFFAKKAARMGKFLKKGVPDVVAAARSVLNDWNT 410
            .|     :::|....|      |.....|.||.........|.....|.||...:||.:|.|:..
  Rat   480 LEATYGINIIKPGEDE------DPYRPPTSEELLTAYGCMRGFMTAHGQPDQPRSARYILKDYVR 538

  Fly   411 GKIKYCTQPPEVQEGQSVHISASIVHSEAREFDVENFESMETEILEHCAVKTDDIMEITSTGPLE 475
            ||:.||..||    |:                |...|:....::||: .:|.:           |
  Rat   539 GKLLYCHPPP----GK----------------DPVAFQHQHRQLLEN-KIKGE-----------E 571

  Fly   476 IR-QPREEAEPADKITASLVIDEKEKPAKGRKRKLDEEKEKVDPSLLLEEN-QSLNKGIKQMQKL 538
            :| ||                        |:.:|..:.:..||.:...:|| ::|.||::.:...
  Rat   572 LRLQP------------------------GKTQKAKQVENVVDKTFFHQENVRALTKGVQAVMGY 612

  Fly   539 K---------------------KKQNVRNEKKISK 552
            |                     ||...||:|:.|:
  Rat   613 KPGSGLVTAAAASAENVPGKPWKKHGNRNKKEKSR 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ns1	NP_732199.2	GN3L_Grn1	17..88	CDD:285863	7/20 (35%)
		SurA_N_3	59..>150	CDD:304439	14/82 (17%)
		RbgA	121..443	CDD:224083	89/432 (21%)
		Nucleostemin_like	152..322	CDD:206753	57/262 (22%)
		Ras_like_GTPase	271..>400	CDD:206648	39/146 (27%)
Lsg1	NP_001013439.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
		RbgA	151..551	CDD:224083	89/425 (21%)
		HSR1_MMR1	163..441	CDD:206750	62/277 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	253..359		6/105 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	625..655		6/23 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810