DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ns1 and GNL3

DIOPT Version :9

Sequence 1:	NP_732199.2	Gene:	Ns1 / 42060	FlyBaseID:	FBgn0038473	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_055181.3	Gene:	GNL3 / 26354	HGNCID:	29931	Length:	549	Species:	Homo sapiens

Alignment Length:	586	Identity:	197/586 - (33%)
Similarity:	307/586 - (52%)	Gaps:	46/586 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LKRLKTKK-SKRLTGRLKHKIEKKVRDHNKKERRAAKKNPKKGSKK-QKLIQIPNICPFKDDILK 65
            :||.|.|| |||:|...::||:||||:|::|.|:.||   |:|.|| :|...:||..|||:.:|:
Human     1 MKRPKLKKASKRMTCHKRYKIQKKVREHHRKLRKEAK---KRGHKKPRKDPGVPNSAPFKEALLR 62

  Fly    66 EVEEAKQRQEAERLARREAFKAEREQNKFKTLESMVEDADMRSTVHGIMHENDAQDQDEKKYKNA 130
            |.|..|||  .|.|.:::....::|..|.:.||:   :.|::.:....|.:.....:.|.|.|:.
Human    63 EAELRKQR--LEELKQQQKLDRQKELEKKRKLET---NPDIKPSNVEPMEKEFGLCKTENKAKSG 122

  Fly   131 VTKEQSLKQYFKEFRKVIENADVVLEVVDARDPLGTRCNEVERAVRGAPGNKRLVLVLNKADLVP 195
              |:.|.|.|.:|.:||||.:||||||:|||||||.||.:||.|:..: |.|:|||:|||:||||
Human   123 --KQNSKKLYCQELKKVIEASDVVLEVLDARDPLGCRCPQVEEAIVQS-GQKKLVLILNKSDLVP 184

  Fly   196 RENLNNWIKYFRRSGPVTAFKASTQDQANRLGRRKLREMKTEKAMQGSVCIGAELLMSMLGNYCR 260
            :|||.:|:.|.::..|...|:|||:.:......::::..|.....:..||.|.|.|..:||.:
Human   185 KENLESWLNYLKKELPTVVFRASTKPKDKGKITKRVKAKKNAAPFRSEVCFGKEGLWKLLGGF-- 247

  Fly   261 NKGIKTSIRVGVVGIPNVGKSSIINSLTRGRSCMVGSTPGVTKSMQEVELDSKIKLIDCPGIVFT 325
            .:....:|||||:|.||||||||||||.:.:.|.||.:.|:|:|||.|.||.:|.:||.|..:.:
Human   248 QETCSKAIRVGVIGFPNVGKSSIINSLKQEQMCNVGVSMGLTRSMQVVPLDKQITIIDSPSFIVS 312

  Fly   326 SGGENSHAVLKNAQRVGDVKDPFTIAESVLKRASKEYFCTMYDITNYDTFEEFFAKKAARMGKFL 390
            ....:|...|::...:..|| |...|.::|.:|........|.:..|....|||...|.|.|...
Human   313 PLNSSSALALRSPASIEVVK-PMEAASAILSQADARQVVLKYTVPGYRNSLEFFTVLAQRRGMHQ 376

  Fly   391 KKGVPDVVAAARSVLNDWNTGKIKYCTQPPEVQEGQSVHISASIVHSEAREFDVENFESMETEIL 455
            |.|:|:|..||:.:.::|....:.|...|| .......:.:.|||......|::|..|....:.:
Human   377 KGGIPNVEGAAKLLWSEWTGASLAYYCHPP-TSWTPPPYFNESIVVDMKSGFNLEELEKNNAQSI 440

  Fly   456 EHCAVK----TDDIMEITS---TGPLEIRQPREEAEPADKITASLVIDEKEKPAKGRKRKLDEEK 513
            .  |:|    .:.|:..:|   .|.:|.:...||           :...||:..:.|:...|.::
Human   441 R--AIKGPHLANSILFQSSGLTNGIIEEKDIHEE-----------LPKRKERKQEEREDDKDSDQ 492

  Fly   514 EKVDPSLLLEENQSLNKGIKQMQKLKKKQNVRNEKKISKITDVLDSFSLGPSSSKAEKYDFDEDY 578
            |.||..  ::||.|.....::..:...::....|:...       ||.|.....:.:.|||..||
Human   493 ETVDEE--VDENSSGMFAAEETGEALSEETTAGEQSTR-------SFILDKIIEEDDAYDFSTDY 548

  Fly   579 V 579
            |
Human   549 V 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ns1	NP_732199.2	GN3L_Grn1	17..88	CDD:285863	29/71 (41%)
		SurA_N_3	59..>150	CDD:304439	27/90 (30%)
		RbgA	121..443	CDD:224083	122/321 (38%)
		Nucleostemin_like	152..322	CDD:206753	81/169 (48%)
		Ras_like_GTPase	271..>400	CDD:206648	50/128 (39%)
GNL3	NP_055181.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..56		27/57 (47%)
		Basic. /evidence=ECO:0000250	2..46		24/46 (52%)
		GN3L_Grn1	16..85	CDD:285863	29/73 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	73..104		6/33 (18%)
		RbgA	133..419	CDD:224083	112/290 (39%)
		Nucleostemin_like	142..307	CDD:206753	80/167 (48%)
		Intermediate. /evidence=ECO:0000250	282..456		49/177 (28%)
		Acidic. /evidence=ECO:0000250	465..543		17/97 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	474..532		13/66 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1210675at2759
OrthoFinder	1	1.000	-	-		FOG0002318
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101399
Panther	1	1.100	-	-	O	PTHR11089
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R524
SonicParanoid	1	1.000	-	-		X1530
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.810