DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ns1 and Gnl2

DIOPT Version :9

Sequence 1:	NP_732199.2	Gene:	Ns1 / 42060	FlyBaseID:	FBgn0038473	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_663527.2	Gene:	Gnl2 / 230737	MGIID:	2385207	Length:	728	Species:	Mus musculus

Alignment Length:	632	Identity:	182/632 - (28%)
Similarity:	272/632 - (43%)	Gaps:	152/632 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KSKRLTGRLKHKIEKKVRDHNKK------ERRAAKKNPKKGSKKQKLIQIPNICPFKDDILKEVE 68
            |..:|...|.|   .:::.||.|      |...:...||...|:      ||:  |..|:...:|
Mouse   112 KQSKLPMSLLH---DRIQPHNAKVHILDTESFESTFGPKSQRKR------PNL--FASDMQSLLE 165

  Fly    69 EAKQRQEAERLARREAFKAEREQNKFKTLESMVEDADMRSTVHGIMHENDAQDQDEKKYKNAVTK 133
            .|:...|:            .:|.|.:.|  ::||..:|         |:||   |:.||    |
Mouse   166 NAEMSTES------------YDQGKDRDL--VMEDTGVR---------NEAQ---EEIYK----K 200

  Fly   134 EQSLKQYFKEFRKVIENADVVLEVVDARDPLGTRCNEVERAVRGAPGNKRLVLVLNKADLVPREN 198
            .|| |:.:.|..|||:::|||::|:|||||:|||...:|..::.....|.|:.||||.||||...
Mouse   201 GQS-KRIWGELYKVIDSSDVVVQVLDARDPMGTRSPHIEAYLKKEKPWKHLIFVLNKCDLVPTWA 264

  Fly   199 LNNWIKYFRRSGPVTAFKASTQDQANRLGRRKLREMKTEKAMQGSVCIGAELLMSMLGNYCRNKG 263
            ...|:....:..|..||.||.   .|..|:                  ||  .:.:|..:.:...
Mouse   265 TKRWVAVLSQDYPTLAFHASL---TNPFGK------------------GA--FIQLLRQFGKLHT 306

  Fly   264 IKTSIRVGVVGIPNVGKSSIINSLTRGRSCMVGSTPGVTKSMQEVELDSKIKLIDCPGIVFTSGG 328
            .|..|.||.:|.|||||||:||:|...:.|.|....|.||..|.:.|..:|.||||||:|:.|..
Mouse   307 DKKQISVGFIGYPNVGKSSVINTLRSKKVCNVAPIAGETKVWQYITLMRRIFLIDCPGVVYPSED 371

  Fly   329 ENSHAVLKNAQRVGDVKDPFTIAESVLKRASKEYFCTMYDITNYDTFEEFFAKKAARMGKFLKKG 393
            ..:..|||...:|..:|.|.....:||:||..||....|.|.:::..|:|..|.|.|.||.||.|
Mouse   372 SETDIVLKGVVQVEKIKAPQDHIGAVLERAKPEYISKTYKIESWENAEDFLEKLALRTGKLLKGG 436

  Fly   394 VPDVVAAARSVLNDWNTGKIKYCTQPPEVQ---EGQSVHISASIVHSEAREFDVENFESMETEIL 455
            .||::..::.|||||..|:|.:..:||..:   :.|....|...|.:|..:.:.|. |:.|||:.
Mouse   437 EPDMLTVSKMVLNDWQRGRIPFFVKPPNAELPTDSQLPPSSPLEVPTETTQNNPEE-ETTETEVE 500

  Fly   456 E-----------HCA----------------------------------VKTDDIMEITSTGPLE 475
            .           .|:                                  |:..|:.::.|:|..|
Mouse   501 RSDSITEKEPEGDCSQDRNSEMQQILARVRQNFGKINVGPQFSADDLVPVEMSDLEDLESSGEEE 565

  Fly   476 IRQPREEAEPADKITASLVIDEKEKP----AKGRKRKLDEEKEKVDPSLLLEENQSLNKGIKQMQ 536
            .::..:..|.|::..:.   |.:|:|    .|...|.|||:        :.:..:.|||.
Mouse   566 EQEQEQPGEDAEEERSP---DTQEEPVGNDTKAVLRALDEK--------IAKYQRFLNKA----- 614

  Fly   537 KLKKKQNVRNEKKIS----------KITDVLDSFSLGPSSSKAEKYD 573
            |.||...||..|.:|          |.|...|| ...| :.||.|:|
Mouse   615 KAKKFSAVRISKDLSEKVFAKYKEEKKTSAEDS-DAAP-TKKARKWD 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ns1	NP_732199.2	GN3L_Grn1	17..88	CDD:285863	16/76 (21%)
		SurA_N_3	59..>150	CDD:304439	25/90 (28%)
		RbgA	121..443	CDD:224083	115/324 (35%)
		Nucleostemin_like	152..322	CDD:206753	62/169 (37%)
		Ras_like_GTPase	271..>400	CDD:206648	54/128 (42%)
Gnl2	NP_663527.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33
		NGP1NT	43..174	CDD:400461	18/84 (21%)
		NGP_1	209..365	CDD:206751	66/178 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	462..521		12/59 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	538..595		10/59 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	636..728		9/26 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810