Protein Alignment Dad and Smad9

DIOPT Version :10

• Sequence 1: NP_001369021.1
• Gene: Dad / 42059
• FlyBaseID: FBgn0020493
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: NP_620227.2
• Gene: Smad9 / 85435
• RGDID: 71004
• Length: 430
• Species: Rattus norvegicus
• Alignment Length: 464
• Identity: 114/464 - (24%)
• Similarity: 184/464 - (39%)
• Gaps: 122/464 - (26%)

  Fly   196 PVSTSRATAHPPQTQAQNGKRFRED-------FEALMKQLKRKQRNELLLAVKSRLDPPTKTQRD 253
            |:|:..:...|...:....|:..|:       .::|:|:||:|                 |...|
  Rat     6 PISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKK-----------------KGAMD 53

  Fly   254 VVEPTTTTAPTYLQCILIPCKTQTVWE-------PHVTASRLFFWRELWNAKELKRLPTC--PAA 309
            .:|...:......:|:.||.......:       |||...|::.|.:|.:..|||.|..|  |..
  Rat    54 ELERALSCPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFG 118

  Fly   310 RDCIYMCCNPLHWFRILHQPETESPT-PPY----------QRSKMLRLKDADFEED-------SQ 356
            .....:|.||.|:.|:      |:|. ||.          |.|.:.:.:.|....:       :.
  Rat   119 SKQKEVCINPYHYRRV------ETPVLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATY 177

  Fly   357 NDAKSAAL--------------------------STWSAESTSISNIYKPALYESVTTDGKDHNI 395
            .|:...:|                          |...::|....:.::|..||...     |
  Rat   178 PDSFQQSLGPAPPSSPGHVFPQSPCPTSYPQSPGSPSESDSPYQHSDFRPVCYEEPL-----H-- 235

  Fly   396 NSQVWCQIAYWEMAHRVGEFFHAKTNAVNI--YTDGIVASEVDSMCLRDLTPAGNQIHSVVPKAR 458
                ||.:||:|:.:||||.|.|.:.:|.|  :||  .::..:..||..|:....  :|.:...|
  Rat   236 ----WCSVAYYELNNRVGETFQASSRSVLIDGFTD--PSNNRNRFCLGLLSNVNR--NSTIENTR 292

  Fly   459 HTVGLGVTLSLENGDVWIYNRGNTTIFVDSPTLSENLD--------RVCKVMPGYCLKAFETNR- 514
            ..:|.||.|....|:|:.....:::|||.    |.|.:        .|||:..|..||.|....
  Rat   293 RHIGKGVHLYYVGGEVYAECVSDSSIFVQ----SRNCNYQHGFHPATVCKIPSGCSLKVFNNQLF 353

  Fly   515 AELLSMRDHGHHPMGPV----DYFSIKISFGKGWGRDYKRQDIMGCPCWLEVHFSHLRXQYL--M 573
            |:||:  ...||....|    ...:|::||.||||.:|.|||:...|||:|:|. |...|:|  :
  Rat   354 AQLLA--QSVHHGFEVVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHL-HGPLQWLDKV 415

  Fly   574 LARSAGPHS 582
            |.:...||:
  Rat   416 LTQMGSPHN 424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dad	NP_001369021.1	MH1_SMAD_6_7	197..329	CDD:199813	32/147 (22%)
		MH2_I-SMAD	400..565	CDD:199821	60/179 (34%)
Smad9	NP_620227.2	MH1_SMAD_1_5_9	13..136	CDD:199814	31/145 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	171..222		4/50 (8%)
		MH2	230..430	CDD:469593	69/217 (32%)