Protein Alignment Dad and Smad7

DIOPT Version :10

• Sequence 1: NP_001369021.1
• Gene: Dad / 42059
• FlyBaseID: FBgn0020493
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: NP_110485.1
• Gene: Smad7 / 81516
• RGDID: 69314
• Length: 426
• Species: Rattus norvegicus
• Alignment Length: 424
• Identity: 132/424 - (31%)
• Similarity: 186/424 - (43%)
• Gaps: 98/424 - (23%)

  Fly   180 CCGGATESTSGSTLTIPVSTSRATAHPPQTQAQNGKRFREDFEAL----MKQLKRKQRNELLLAV 240
            |.|.|.....|          ....|||.:.|........|.:||    :|:||.:|...||.||
  Rat    61 CLGKAVRGAKG----------HHHPHPPSSGAGAAGGAEADLKALTHSVLKKLKERQLELLLQAV 115

  Fly   241 KSRLDPPTKTQRDVVEPTTTTAPTYLQCILIPCKTQTVWEPHVTAS-----------------RL 288
            :||             ..|.||     |:|:|.:......|...||                 ::
  Rat   116 ESR-------------GGTRTA-----CLLLPGRLDCRLGPGAPASAQPAQPPSSYSLPLLLCKV 162

  Fly   289 FFWRELWNAKELKRLPTCPAARDCIY-------MCCNPLHWFRILHQPETESPTPPYQRSKMLRL 346
            |.|.:|.::.|:|||..|.:     |       :||||.|..|:.   |.|||.|||.|..|..|
  Rat   163 FRWPDLRHSSEVKRLCCCES-----YGKINPELVCCNPHHLSRLC---ELESPPPPYSRYPMDFL 219

  Fly   347 K-DADFEEDSQNDAKSAALSTWSAESTSISNIYKP-ALYES---VTTDGKDHNINSQVWCQIAYW 406
            | .||..:           :..|::.|..:|...| .|.:|   :....:.|      ||.:|||
  Rat   220 KPTADCPD-----------AVPSSDETGGTNYLAPGGLSDSQLLLEPGDRSH------WCVVAYW 267

  Fly   407 EMAHRVGEFFHAKTNAVNIYTDGIVASEVDSMCLRDLTPAGNQIHSVVPKARHTVGLGVTLSLEN 471
            |...|||..:..:..:::|:.|   ..:.:..||..|.  .:....:|.|.|..:|.|:.|:.|.
  Rat   268 EEKTRVGRLYCVQEPSLDIFYD---LPQGNGFCLGQLN--SDNKSQLVQKVRSKIGCGIQLTREV 327

  Fly   472 GDVWIYNRGNTTIFVDSPTLSENLDR----VCKVMPGYCLKAFETNRAELLSMRDHGHHPM-GPV 531
            ..||:|||.:..||:.|.|| :|.|.    |.||.||:.:|||:..:|..| .|.:.|..| .|.
  Rat   328 DGVWVYNRSSYPIFIKSATL-DNPDSRTLLVHKVFPGFSIKAFDYEKAYSL-QRPNDHEFMQQPW 390

  Fly   532 DYFSIKISFGKGWGRDYKRQDIMGCPCWLEVHFS 565
            ..|:::|||.||||:.|.||.|..|||||||.|:
  Rat   391 TGFTVQISFVKGWGQCYTRQFISSCPCWLEVIFN 424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dad	NP_001369021.1	MH1_SMAD_6_7	197..329	CDD:199813	41/159 (26%)
		MH2_I-SMAD	400..565	CDD:199821	66/169 (39%)
Smad7	NP_110485.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	14..40
		MH1_SMAD_7	60..205	CDD:199818	46/179 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	67..88		5/30 (17%)
		Important for interaction with SMURF2. /evidence=ECO:0000250	208..217		4/8 (50%)
		PY-motif. /evidence=ECO:0000250	208..211		1/2 (50%)
		MH2_SMAD_7	254..424	CDD:199825	67/182 (37%)