DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dad and Smad7

DIOPT Version :9

Sequence 1:	NP_001369021.1	Gene:	Dad / 42059	FlyBaseID:	FBgn0020493	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_110485.1	Gene:	Smad7 / 81516	RGDID:	69314	Length:	426	Species:	Rattus norvegicus

Alignment Length:	424	Identity:	132/424 - (31%)
Similarity:	186/424 - (43%)	Gaps:	98/424 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 CCGGATESTSGSTLTIPVSTSRATAHPPQTQAQNGKRFREDFEAL----MKQLKRKQRNELLLAV 240
            |.|.|.....|          ....|||.:.|........|.:||    :|:||.:|...||.||
  Rat    61 CLGKAVRGAKG----------HHHPHPPSSGAGAAGGAEADLKALTHSVLKKLKERQLELLLQAV 115

  Fly   241 KSRLDPPTKTQRDVVEPTTTTAPTYLQCILIPCKTQTVWEPHVTAS-----------------RL 288
            :||             ..|.||     |:|:|.:......|...||                 ::
  Rat   116 ESR-------------GGTRTA-----CLLLPGRLDCRLGPGAPASAQPAQPPSSYSLPLLLCKV 162

  Fly   289 FFWRELWNAKELKRLPTCPAARDCIY-------MCCNPLHWFRILHQPETESPTPPYQRSKMLRL 346
            |.|.:|.::.|:|||..|.:     |       :||||.|..|:.   |.|||.|||.|..|..|
  Rat   163 FRWPDLRHSSEVKRLCCCES-----YGKINPELVCCNPHHLSRLC---ELESPPPPYSRYPMDFL 219

  Fly   347 K-DADFEEDSQNDAKSAALSTWSAESTSISNIYKP-ALYES---VTTDGKDHNINSQVWCQIAYW 406
            | .||..:           :..|::.|..:|...| .|.:|   :....:.|      ||.:|||
  Rat   220 KPTADCPD-----------AVPSSDETGGTNYLAPGGLSDSQLLLEPGDRSH------WCVVAYW 267

  Fly   407 EMAHRVGEFFHAKTNAVNIYTDGIVASEVDSMCLRDLTPAGNQIHSVVPKARHTVGLGVTLSLEN 471
            |...|||..:..:..:::|:.|   ..:.:..||..|.  .:....:|.|.|..:|.|:.|:.|.
  Rat   268 EEKTRVGRLYCVQEPSLDIFYD---LPQGNGFCLGQLN--SDNKSQLVQKVRSKIGCGIQLTREV 327

  Fly   472 GDVWIYNRGNTTIFVDSPTLSENLDR----VCKVMPGYCLKAFETNRAELLSMRDHGHHPM-GPV 531
            ..||:|||.:..||:.|.|| :|.|.    |.||.||:.:|||:..:|..| .|.:.|..| .|.
  Rat   328 DGVWVYNRSSYPIFIKSATL-DNPDSRTLLVHKVFPGFSIKAFDYEKAYSL-QRPNDHEFMQQPW 390

  Fly   532 DYFSIKISFGKGWGRDYKRQDIMGCPCWLEVHFS 565
            ..|:::|||.||||:.|.||.|..|||||||.|:
  Rat   391 TGFTVQISFVKGWGQCYTRQFISSCPCWLEVIFN 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dad	NP_001369021.1	MH1_SMAD_6_7	197..329	CDD:199813	41/159 (26%)
Dad	NP_001369021.1	MH2_I-SMAD	400..565	CDD:199821	66/169 (39%)
Smad7	NP_110485.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	14..40
		MH1_SMAD_7	60..205	CDD:199818	46/179 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..88		5/30 (17%)
		Important for interaction with SMURF2. /evidence=ECO:0000250	208..217		4/8 (50%)
		PY-motif. /evidence=ECO:0000250	208..211		1/2 (50%)
		MH2_SMAD_7	254..424	CDD:199825	67/182 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337660
Domainoid	1	1.000	113	1.000	Domainoid score	I5981
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	147	1.000	Inparanoid score	I4315
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D193735at33208
OrthoFinder	1	1.000	-	-		FOG0003707
OrthoInspector	1	1.000	-	-		otm44627
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13703
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.860