DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dad and gb:cr929477

DIOPT Version :9

Sequence 1:	NP_001369021.1	Gene:	Dad / 42059	FlyBaseID:	FBgn0020493	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	XP_009299441.1	Gene:	gb:cr929477 / 794669	ZFINID:	ZDB-GENE-141211-39	Length:	505	Species:	Danio rerio

Alignment Length:	524	Identity:	134/524 - (25%)
Similarity:	192/524 - (36%)	Gaps:	174/524 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 ATESTSGSTLTIPVSTSRATAHPPQTQAQNGKRFREDF-----EALMKQLKRKQRNELLLAVKSR 243
            :|.:::.:.|:|        .|......|.|:  .|.|     |:|:|:||.|         |..
Zfish     5 STPTSNDACLSI--------VHSLMCHRQGGE--SESFSKRAIESLVKKLKEK---------KDE 50

  Fly   244 LDPPTKTQRDVVEPTTTTAPTYLQCILI----PCKTQTVWE---PHVTASRLFFWRELWNAKELK 301
            ||       .::...||......:|:.|    ..:.|....   |||..:||:.|.:| :..|||
Zfish    51 LD-------SLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDL-HKNELK 107

  Fly   302 RLPTCPAARD--CIYMCCNPLHWFRIL-------------------------------------- 326
            .:..|..|.|  |..:|.||.|:.|::
Zfish   108 HVKYCQFAFDLKCDNVCVNPYHYERVVSPSIDLSVLTLGGPGPSGELMVKEEFEGQSSHSAADGG 172

  Fly   327 HQPETESPT-----PPYQRSKMLRLKDADFEEDSQNDAKSA-------ALSTWSAESTSISNI-- 377
            |..:|...|     ||...:..:.|..||....:...|.||       |.|:|...|:...:|
Zfish   173 HSIQTIQHTATPSAPPDTFNSPVLLPPADHTSSTSTSAFSAMAAGPNNAPSSWPRGSSFPPSIPH 237

  Fly   378 ------YKPAL-----YESVTTDGKDHN-------INS----QVWCQIAYWEMAHRVGEFFHAKT 420
                  :.|.|     |.||      ||       |::    ..||.|||:||..:|||.|...:
Zfish   238 QNGHLQHHPPLPHTGQYWSV------HNELAFQPPISTHPAPDYWCSIAYFEMDIQVGETFKVPS 296

  Fly   421 NAVNIYTDGIV-ASEVDSMCLRDLTPAGNQIH--SVVPKARHTVGLGVTLSLE-NGDVWIYNRGN 481
            |...:..||.| .|..|..||..|    :.:|  ..:.:||..:|.||.|..: .||||:....:
Zfish   297 NCPVVTVDGYVDPSGGDRFCLGQL----SNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSD 357

  Fly   482 TTIFVDSPTLSENL-----DRVCKVMPGYCLKAFE-------------TNRAELLSMRD--HGHH 526
            ..:||.|..|....     |.|.|:.|...:|.|:             |.:|...:..|  .|:.
Zfish   358 HAVFVQSYYLDREAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQAAAAAQADAVAGNI 422

  Fly   527 PMGP-------------------VDYFS----IKISFGKGWGRDYKRQDIMGCPCWLEVHFSHLR 568
            | ||                   ||...    :::||.||||.||.||.|...|||:|:|. |..
Zfish   423 P-GPGSVGGIAPAISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQSIKETPCWIEIHL-HRA 485

  Fly   569 XQYL 572
             |.|
Zfish   486 LQLL 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dad	NP_001369021.1	MH1_SMAD_6_7	197..329	CDD:199813	39/183 (21%)
Dad	NP_001369021.1	MH2_I-SMAD	400..565	CDD:199821	66/211 (31%)
gb:cr929477	XP_009299441.1	MH1_SMAD_4	11..135	CDD:199816	40/150 (27%)
gb:cr929477	XP_009299441.1	MH2_SMAD_4	273..494	CDD:199823	69/223 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910