Protein Alignment Dad and Smad5

DIOPT Version :10

• Sequence 1: NP_001369021.1
• Gene: Dad / 42059
• FlyBaseID: FBgn0020493
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: NP_067724.1
• Gene: Smad5 / 59328
• RGDID: 620158
• Length: 465
• Species: Rattus norvegicus
• Alignment Length: 466
• Identity: 114/466 - (24%)
• Similarity: 173/466 - (37%)
• Gaps: 151/466 - (32%)

  Fly   222 EALMKQLKRKQ--RNELLLAVKSRLDPPTKTQRDVVEPTTTTAPTYLQCILIPCKTQTVWE---- 280
            :||:|:||:|:  ..||..|:.|...|.                   :|:.||.......:
  Rat    36 DALVKKLKKKKGAMEELEKALSSPGQPS-------------------KCVTIPRSLDGRLQVSHR 81

  Fly   281 ---PHVTASRLFFWRELWNAKELKRLPTC--PAARDCIYMCCNPLHWFRI--------------- 325
               |||...|::.|.:|.:..|||.|..|  |.......:|.||.|:.|:
  Rat    82 KGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKEVCINPYHYKRVESPVLPPVLVPRHNE 146

  Fly   326 ------------------------------LHQPET-------ESPTPP------YQRSKMLRLK 347
                                          .|||.:       .||.||      |..|......
  Rat   147 FNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQPNSTPFPLSPNSPYPPSPASSTYPNSPASSGP 211

  Fly   348 DADFE-------------EDSQNDAKSAALSTWSAESTSISNIYKPALYESVTT--------DGK 391
            .:.|:             :|......|..:.|        ||...|.:..|:::        :..
  Rat   212 GSPFQLPADTPPPAYMPPDDQMGQDNSQPMDT--------SNNMIPQIMPSISSRDVQPVAYEEP 268

  Fly   392 DHNINSQVWCQIAYWEMAHRVGEFFHAKTNAVNI--YTDGIVASEVDSMCLRDLTPAGNQIHSVV 454
            .|      ||.|.|:|:.:||||.|||.:.:|.:  :||  .|:.....||..|:....  :|.:
  Rat   269 KH------WCSIVYYELNNRVGEAFHASSTSVLVDGFTD--PANNKSRFCLGLLSNVNR--NSTI 323

  Fly   455 PKARHTVGLGVTLSLENGDVWIYNRGNTTIFVDS----------PTLSENLDRVCKVMPGYCLKA 509
            ...|..:|.||.|....|:|:.....:::|||.|          ||      .|||:.....||.
  Rat   324 ENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNFHHGFHPT------TVCKIPSSCSLKI 382

  Fly   510 FETNR-AELLSMR-DHGHHPMGPVDYF-SIKISFGKGWGRDYKRQDIMGCPCWLEVHFSHLRXQY 571
            |.... |:||:.. :||...:..:... :|::||.||||.:|.|||:...|||:|:|. |...|:
  Rat   383 FNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHL-HGPLQW 446

  Fly   572 L--MLARSAGP 580
            |  :|.:...|
  Rat   447 LDKVLTQMGSP 457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dad	NP_001369021.1	MH1_SMAD_6_7	197..329	CDD:199813	32/162 (20%)
		MH2_I-SMAD	400..565	CDD:199821	60/179 (34%)
Smad5	NP_067724.1	MH1_SMAD_1_5_9	10..133	CDD:199814	31/115 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..243		12/79 (15%)
		MH2_SMAD_1_5_9	265..465	CDD:199822	66/210 (31%)