Protein Alignment Dad and smad3a

DIOPT Version :10

• Sequence 1: NP_001369021.1
• Gene: Dad / 42059
• FlyBaseID: FBgn0020493
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: NP_571646.1
• Gene: smad3a / 58092
• ZFINID: ZDB-GENE-000509-3
• Length: 425
• Species: Danio rerio
• Alignment Length: 392
• Identity: 108/392 - (27%)
• Similarity: 161/392 - (41%)
• Gaps: 88/392 - (22%)

  Fly   239 AVKSRLDPPTKT-QRDVVEPTTTTAPTYLQCILIPCKTQTVWE-------PHVTASRLFFWRELW 295
            ||||.:....|| |.|.:|...||.....:||.||.......:       |||...||:.|.:|.
Zfish    33 AVKSLVKKLKKTGQLDELEKAITTQDVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLQ 97

  Fly   296 NAKELKRLPTCPAA----RDCIYMCCNPLHWFR--------ILHQPETESPT--PP---YQRSKM 343
            :..||:.:..|..|    :|  .:|.||.|:.|        :|....||.|:  ||   |..|
Zfish    98 SHHELRAIELCEFAFHMKKD--EVCVNPYHYQRVETPVLPPVLVPRHTEIPSEFPPLDDYSHS-- 158

  Fly   344 LRLKDADFEEDSQNDAKSAALSTWSAESTSISNIYKPALYESVTTDGKDHNINSQV--------- 399
                   ..|::...|.....|.:..|:       .|..|.|...:..||.:|..:
Zfish   159 -------IPENTIFPAGIEPQSNYIPET-------PPPGYISEDGETSDHQMNRSMDTGSPNLSP 209

  Fly   400 ----------------------WCQIAYWEMAHRVGEFFHAKTNAVNI--YTDGIVASEVDSMCL 440
                                  ||.|:|:|:..||||.|||...::.:  :||   .|..:..||
Zfish   210 NPVSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSLTVDGFTD---PSNSERFCL 271

  Fly   441 RDLTPAGNQIHSVVPKARHTVGLGVTLSLENGDVWIYNRGNTTIFVDSPTLSENLD----RVCKV 501
            ..|:....  ::.|...|..:|.||.|....|:|:.....::.|||.||..::...    .|||:
Zfish   272 GLLSNVNR--NAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKI 334

  Fly   502 MPGYCLKAFETNR-AELLSMR-DHGHHPMGPVDYF-SIKISFGKGWGRDYKRQDIMGCPCWLEVH 563
            .||..||.|.... |.||:.. :.|...:..:... :|::||.||||.:|:||.:...|||:|:|
Zfish   335 PPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELH 399

  Fly   564 FS 565
            .:
Zfish   400 LN 401

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dad	NP_001369021.1	MH1_SMAD_6_7	197..329	CDD:199813	33/109 (30%)
		MH2_I-SMAD	400..565	CDD:199821	58/173 (34%)
smad3a	NP_571646.1	MH1_SMAD_2_3	7..131	CDD:199815	32/99 (32%)
		MH2_SMAD_2_3	224..414	CDD:199826	58/183 (32%)