DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dad and smad6b

DIOPT Version :9

Sequence 1:	NP_001369021.1	Gene:	Dad / 42059	FlyBaseID:	FBgn0020493	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_001038516.1	Gene:	smad6b / 564395	ZFINID:	ZDB-GENE-050419-198	Length:	486	Species:	Danio rerio

Alignment Length:	518	Identity:	149/518 - (28%)
Similarity:	217/518 - (41%)	Gaps:	108/518 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 GQGHNNN--NSHPYRRLPNHMDVLPPPPSAC------DRCCTAPGYSCASSCDDMLIDGSDLDQD 152
            |:|..::  .::| .::|. .:..|..||..      :.|...|..|....     ..|..||||
Zfish    32 GEGSRDDLLGTNP-EKIPK-TEFRPMTPSGSPSVDYGEVCTRNPAESSGGG-----TSGGFLDQD 89

  Fly   153 -------RSPDQGQVQPVDRRMISATTFTTMFRKCC--------GGATESTSGSTLTI--PVSTS 200
                   .||  ..||..|.|.::          ||        .|:.....||...:  .:.:|
Zfish    90 GGTVCTVGSP--RSVQDSDCRTVT----------CCLFKDRDHHSGSRSPEPGSCQFVLRNIGSS 142

  Fly   201 RATAHPPQTQAQNGK-------RFREDFEALMKQLKRKQRNELLLAVKSRLDPPTKTQRDVVEPT 258
            |   .|...::|..|       ..:....:|:|:||.|..:.||.||:|...|.
Zfish   143 R---DPGPLESQESKPRSVMEQELKTATYSLLKRLKEKTLDTLLEAVESGGMPS----------- 193

  Fly   259 TTTAPTYLQCILIPCKTQT-----VWEPHVTASRLFFWRELWNAKELKRLPTCPA--ARDCIYMC 316
                    .|::: .:|:.     :..|.:...:|:.|.:|.:..:||.|..|.:  |:|...:|
Zfish   194 --------DCVMV-SRTELRLGGHMAPPQLLICKLYRWSDLQHTAQLKALCECKSFGAQDGPVVC 249

  Fly   317 CNPLHWFRILHQPETESPTPPYQRSKMLRLKDADFEEDSQNDAKSAALSTWSAESTSISNIYKPA 381
            |||.|:.|:.   ..|||.|||.|.       :..||....|...:.||....|:.|..|..:..
Zfish   250 CNPYHYSRLC---GPESPPPPYSRL-------SPSEEHKPLDLSDSTLSYTETEAASSPNATQGE 304

  Fly   382 LYE-SVTTDG--KDHNINSQVWCQIAYWEMAHRVGEFFHAKTNAVNIYTDGIVASEVDSMCLRDL 443
            ..: |::.|.  :.|      ||.:||||...|||..:.....||:|:.|   ..:....||..|
Zfish   305 FSDASLSPDAPKQSH------WCNVAYWEHRTRVGRLYTVYQPAVSIFYD---LPQGTGFCLGQL 360

  Fly   444 TPAGNQIHSVVPKARHTVGLGVTLSLENGDVWIYNRGNTTIFVDSPTLSENLDR---VCKVMPGY 505
            :.  :|..|.|.:.|..:|.|:.||.|...||.|||....|||:||||.....|   |.||||||
Zfish   361 SL--DQRSSTVQRTRGKIGYGLLLSKEPDGVWAYNRSQHPIFVNSPTLDVPGSRSLVVRKVMPGY 423

  Fly   506 CLKAFETNRAELLSMRDHGHHPMGPVDYFSIKISFGKGWGRDYKRQDIMGCPCWLEVHFSHLR 568
            .:|.|:..|:.:|..........||.|..|::|||.||||..|.||.|..||||||:..::.|
Zfish   424 SIKVFDYERSSMLRQGAESELLDGPYDPNSVRISFAKGWGPCYSRQFITSCPCWLEILLNNHR 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dad	NP_001369021.1	MH1_SMAD_6_7	197..329	CDD:199813	34/145 (23%)
Dad	NP_001369021.1	MH2_I-SMAD	400..565	CDD:199821	70/167 (42%)
smad6b	NP_001038516.1	MH1_SMAD_6	152..262	CDD:199817	30/132 (23%)
smad6b	NP_001038516.1	MH2_SMAD_6	311..484	CDD:199824	72/183 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	123	1.000	Domainoid score	I5527
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D193735at33208
OrthoFinder	1	1.000	-	-		FOG0003707
OrthoInspector	1	1.000	-	-		otm26019
orthoMCL	1	0.900	-	-		OOG6_109794
Panther	1	1.100	-	-	LDO	PTHR13703
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5077
SonicParanoid	1	1.000	-	-		X6247
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.810