Protein Alignment Dad and smad6b

DIOPT Version :10

• Sequence 1: NP_001369021.1
• Gene: Dad / 42059
• FlyBaseID: FBgn0020493
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: NP_001038516.1
• Gene: smad6b / 564395
• ZFINID: ZDB-GENE-050419-198
• Length: 486
• Species: Danio rerio
• Alignment Length: 518
• Identity: 149/518 - (28%)
• Similarity: 217/518 - (41%)
• Gaps: 108/518 - (20%)

  Fly    96 GQGHNNN--NSHPYRRLPNHMDVLPPPPSAC------DRCCTAPGYSCASSCDDMLIDGSDLDQD 152
            |:|..::  .::| .::|. .:..|..||..      :.|...|..|....     ..|..||||
Zfish    32 GEGSRDDLLGTNP-EKIPK-TEFRPMTPSGSPSVDYGEVCTRNPAESSGGG-----TSGGFLDQD 89

  Fly   153 -------RSPDQGQVQPVDRRMISATTFTTMFRKCC--------GGATESTSGSTLTI--PVSTS 200
                   .||  ..||..|.|.::          ||        .|:.....||...:  .:.:|
Zfish    90 GGTVCTVGSP--RSVQDSDCRTVT----------CCLFKDRDHHSGSRSPEPGSCQFVLRNIGSS 142

  Fly   201 RATAHPPQTQAQNGK-------RFREDFEALMKQLKRKQRNELLLAVKSRLDPPTKTQRDVVEPT 258
            |   .|...::|..|       ..:....:|:|:||.|..:.||.||:|...|.
Zfish   143 R---DPGPLESQESKPRSVMEQELKTATYSLLKRLKEKTLDTLLEAVESGGMPS----------- 193

  Fly   259 TTTAPTYLQCILIPCKTQT-----VWEPHVTASRLFFWRELWNAKELKRLPTCPA--ARDCIYMC 316
                    .|::: .:|:.     :..|.:...:|:.|.:|.:..:||.|..|.:  |:|...:|
Zfish   194 --------DCVMV-SRTELRLGGHMAPPQLLICKLYRWSDLQHTAQLKALCECKSFGAQDGPVVC 249

  Fly   317 CNPLHWFRILHQPETESPTPPYQRSKMLRLKDADFEEDSQNDAKSAALSTWSAESTSISNIYKPA 381
            |||.|:.|:.   ..|||.|||.|.       :..||....|...:.||....|:.|..|..:..
Zfish   250 CNPYHYSRLC---GPESPPPPYSRL-------SPSEEHKPLDLSDSTLSYTETEAASSPNATQGE 304

  Fly   382 LYE-SVTTDG--KDHNINSQVWCQIAYWEMAHRVGEFFHAKTNAVNIYTDGIVASEVDSMCLRDL 443
            ..: |::.|.  :.|      ||.:||||...|||..:.....||:|:.|   ..:....||..|
Zfish   305 FSDASLSPDAPKQSH------WCNVAYWEHRTRVGRLYTVYQPAVSIFYD---LPQGTGFCLGQL 360

  Fly   444 TPAGNQIHSVVPKARHTVGLGVTLSLENGDVWIYNRGNTTIFVDSPTLSENLDR---VCKVMPGY 505
            :.  :|..|.|.:.|..:|.|:.||.|...||.|||....|||:||||.....|   |.||||||
Zfish   361 SL--DQRSSTVQRTRGKIGYGLLLSKEPDGVWAYNRSQHPIFVNSPTLDVPGSRSLVVRKVMPGY 423

  Fly   506 CLKAFETNRAELLSMRDHGHHPMGPVDYFSIKISFGKGWGRDYKRQDIMGCPCWLEVHFSHLR 568
            .:|.|:..|:.:|..........||.|..|::|||.||||..|.||.|..||||||:..::.|
Zfish   424 SIKVFDYERSSMLRQGAESELLDGPYDPNSVRISFAKGWGPCYSRQFITSCPCWLEILLNNHR 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dad	NP_001369021.1	MH1_SMAD_6_7	197..329	CDD:199813	34/145 (23%)
		MH2_I-SMAD	400..565	CDD:199821	70/167 (42%)
smad6b	NP_001038516.1	MH1_SMAD_6	152..262	CDD:199817	30/132 (23%)
		MH2_SMAD_6	311..484	CDD:199824	72/183 (39%)