Protein Alignment Dad and smad10a

DIOPT Version :9

• Sequence 1: NP_001369021.1
• Gene: Dad / 42059
• FlyBaseID: FBgn0020493
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: NP_001352568.1
• Gene: smad10a / 560317
• ZFINID: ZDB-GENE-060503-248
• Length: 581
• Species: Danio rerio
• Alignment Length: 599
• Identity: 128/599 - (21%)
• Similarity: 183/599 - (30%)
• Gaps: 249/599 - (41%)

  Fly   205 HPPQTQAQNGKRFREDF-----EALMKQLKRKQRNELLLAVKSRLDPPTKTQRDVVEPTTTTAPT 264
            |......|.|:  .|.|     |:|:|:||.|         |..||       .::...||....
Zfish    17 HSLMCHRQGGE--NEGFAKRAIESLVKKLKEK---------KDELD-------SLITAITTNGVH 63

  Fly   265 YLQCILI----PCKTQTVWE---PHVTASRLFFWRELWNAKELKRLPTCPAARDCIY--MCCNPL 320
            ..:|:.|    ..:.|....   |||..:||:.|.:| :..|||.:..|..|.|..|  :|.||.
Zfish    64 PSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDL-HKNELKHVKFCQYAFDLKYDNVCVNPY 127

  Fly   321 HWFRI---------LHQPETE-------------------------------------------- 332
            |:.|:         |...||.
Zfish   128 HYERVVSPGIVGLSLQNTETHLSSGRCLGPTGRLIKEEYSHDCIQMDVPPGLPPQQDHQGAMKLP 192

  Fly   333 ------SPTPPYQ------------------------RSKMLRLKDADFE--------------- 352
                  .|.||.|                        ...|:.::....|
Zfish   193 PPDHYGQPLPPLQLPSEGPRAPPPVTLYSNMPLSPTASGSMMPMQGGHGEGLLQIASPQGQVMTP 257

  Fly   353 -----------------------EDSQNDAKSAAL-----STWSAESTSISNIYKPALYESVTTD 389
                                   ::..|.:|.:..     :||:..||:   .|.|.   ....:
Zfish   258 TPPPSTPTHGPPQTPVPPQPPPNQNGYNSSKHSQTQGSFHTTWTGSSTA---SYTPV---GPQQN 316

  Fly   390 GKDH-------------------------NINSQVWCQIAYWEMAHRVGEFFHAKTNAVNIYTDG 429
            |:.|                         :...:.||.|:|:||..:|||.|...::...:..||
Zfish   317 GRGHQPPLHHPHFWSQHHSSASFPPPVSNHPGPEFWCSISYFEMDVQVGEMFKVLSSCPVVTIDG 381

  Fly   430 IV-ASEVDSMCLRDLTPAGNQIH--SVVPKARHTVGLGVTLSLE-NGDVWIYNRGNTTIFVDSPT 490
            .| .|..|..||..|    :.:|  ....:||..:|.||.|... .||||:....:..:||.|..
Zfish   382 YVDPSGGDRFCLGQL----SNVHRTDASERARLHIGKGVQLECRGEGDVWMRCMSDHAVFVQSYY 442

  Fly   491 LSENL-----DRVCKVMPGYCLKAFETNR---------------AELLSMRDHGHHPMGP----- 530
            |....     |.|.|:.||..:|.|:..:               |...:....|:.| ||
Zfish   443 LDREAGRAPGDAVHKIYPGAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGNIP-GPGSVGG 506

  Fly   531 --------------VDYFS----IKISFGKGWGRDYKRQDIMGCPCWLEVHFSHLRXQYLMLARS 577
                          ||...    :::||.||||.||.||.|...|||:|||. |...|.|.....
Zfish   507 IAPAVSLSAAAGIGVDDLRRLCILRLSFVKGWGPDYPRQSIKHTPCWVEVHL-HRALQLLDEVLH 570

  Fly   578 AGPHSASQHLVEPG 591
            ..|      |.:||
Zfish   571 TMP------LADPG 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dad	NP_001369021.1	MH1_SMAD_6_7	197..329	CDD:199813	39/146 (27%)
		MH2_I-SMAD	400..565	CDD:199821	64/211 (30%)
smad10a	NP_001352568.1	MH1_SMAD_4	10..134	CDD:199816	38/135 (28%)
		MH2_SMAD_4	349..570	CDD:199823	67/226 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810